Search Results - "Sato, Takami"

Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma by Cheng, Hanyin, Chua, Vivian, Liao, Connie, Purwin, Timothy J, Terai, Mizue, Kageyama, Ken, Davies, Michael A, Sato, Takami, Aplin, Andrew E

“…Patients with metastatic uveal melanoma usually die within 1 year of diagnosis, emphasizing an urgent need to develop new treatment strategies. The liver is…”
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Interleukin 10 in the tumor microenvironment: a target for anticancer immunotherapy by Sato, Takami, Terai, Mizue, Tamura, Yutaka, Alexeev, Vitali, Mastrangelo, Michael J., Selvan, Senthamil R.

“…IL-10 is an immunomodulatory cytokine that is frequently upregulated in various types of cancer. The biological role of IL-10 in cancer is quite complex;…”
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Paracrine Effect of NRG1 and HGF Drives Resistance to MEK Inhibitors in Metastatic Uveal Melanoma by Cheng, Hanyin, Terai, Mizue, Kageyama, Ken, Ozaki, Shinji, McCue, Peter A, Sato, Takami, Aplin, Andrew E

“…Uveal melanoma patients with metastatic disease usually die within one year, emphasizing an urgent need to develop new treatment strategies for this cancer…”
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A rat-based preclinical platform facilitating transcatheter hepatic arterial infusion in immunodeficient rats with liver xenografts of patient-derived pancreatic ductal adenocarcinoma by Ozaki, Masanori, Kageyama, Ken, Kimura, Kenjiro, Eguchi, Shinpei, Yamamoto, Akira, Tanaka, Ryota, Nota, Takehito, Yonezawa, Hiroki, Nishiofuku, Hideyuki, Sakai, Yuki, Tani, Naoki, Jogo, Atsushi, Terai, Mizue, Sato, Takami, Ishizawa, Takeaki, Miki, Yukio

“…Liver metastases from pancreatic ductal adenocarcinoma (PDAC) are highly fatal. A rat-based patient-derived tumor xenograft (PDX) model is available for…”
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Expression of Tryptophan 2,3-Dioxygenase in Metastatic Uveal Melanoma by Terai, Mizue, Londin, Eric, Rochani, Ankit, Link, Emma, Lam, Bao, Kaushal, Gagan, Bhushan, Alok, Orloff, Marlana, Sato, Takami

“…Uveal melanoma (UM) is the most common primary eye malignancy in adults and up to 50% of patients subsequently develop systemic metastasis. Metastatic uveal…”
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Stromal fibroblast growth factor 2 reduces the efficacy of bromodomain inhibitors in uveal melanoma by Chua, Vivian, Orloff, Marlana, Teh, Jessica LF, Sugase, Takahito, Liao, Connie, Purwin, Timothy J, Lam, Bao Q, Terai, Mizue, Ambrosini, Grazia, Carvajal, Richard D, Schwartz, Gary, Sato, Takami, Aplin, Andrew E

“…Alterations in transcriptional programs promote tumor development and progression and are targetable by bromodomain and extraterminal (BET) protein inhibitors…”
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Development and optimization of orthotopic liver metastasis xenograft mouse models in uveal melanoma by Sugase, Takahito, Lam, Bao Q, Danielson, Meggie, Terai, Mizue, Aplin, Andrew E, Gutkind, J Silvio, Sato, Takami

“…Patients with metastatic uveal melanoma (MUM) in the liver usually die within 1 year. The development of new treatments for MUM has been limited by the lack of…”
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PD-L1 expression in tumor metastasis is different between uveal melanoma and cutaneous melanoma by Javed, Asad, Arguello, David, Johnston, Curtis, Gatalica, Zoran, Terai, Mizue, Weight, Ryan M, Orloff, Marlana, Mastrangelo, Michael J, Sato, Takami

“…To compare PD-L1 expression between metastatic uveal melanoma (MUM) and metastatic cutaneous melanoma (MCM). A total of 295 MCM and 78 MUM specimens were…”
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Abstract 1137: PRMT5 inhibition regulates alternative splicing and DNA damage repair pathways in SF3B1 R625G expressing uveal melanoma cells by Ito, Koichi, Thodima, Venkat, Carter, Jack, Bhagwat, Neha, Sivakumar, Monisha, Grego, Alexander, Rager, Joseph, Terai, Mizue, Sato, Takami, Abdel-Wahab, Omar, Ruggeri, Bruce, Scherle, Peggy, Vaddi, Kris

“…Abstract PRMT5 (protein arginine methyltransferase 5) is a predominant Type II PRMT that catalyzes symmetric dimethylation of protein arginine residues (sDMA)…”
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Tumor Necrosis Factor-α Blockade and Development of Uveal Melanoma: Expected Adverse Effect or Just Coincidence? by Sato, Takami, MD, PhD

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Establishment of an orthotopic patient-derived xenograft mouse model using uveal melanoma hepatic metastasis by Kageyama, Ken, Ohara, Masahiro, Saito, Kengo, Ozaki, Shinji, Terai, Mizue, Mastrangelo, Michael J, Fortina, Paolo, Aplin, Andrew E, Sato, Takami

“…Metastatic uveal melanoma is a highly fatal disease; most patients die from their hepatic metastasis within 1 year. A major drawback in the development of new…”
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Expression of indoleamine 2,3-dioxygenase in metastatic malignant melanoma recruits regulatory T cells to avoid immune detection and affects survival by Brody, Jonathan R., Costantino, Christina L., Berger, Adam C., Sato, Takami, Lisanti, Michael P., Yeo, Charles J., Emmons, Robert V., Witkiewicz, Agnieszka K.

“…The mechanism by which malignant melanoma (MM) cells survive in lymph nodes is poorly understood. One possible mechanism by which MM cells can escape immune…”
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A case of meningitis due to extensively drug-resistant Pseudomonas aeruginosa imported through medical evacuation: genomic and environmental investigation by Baba, Hiroaki, Kanamori, Hajime, Katsumi, Makoto, Sato, Takami, Chida, Takae, Ikeda, Shinobu, Suzuki, Yuki, Yano, Hisakazu, Tokuda, Koichi

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Prognostic Values of G-Protein Mutations in Metastatic Uveal Melanoma by Terai, Mizue, Shimada, Ayako, Chervoneva, Inna, Hulse, Liam, Danielson, Meggie, Swensen, Jeff, Orloff, Marlana, Wedegaertner, Philip B, Benovic, Jeffrey L, Aplin, Andrew E, Sato, Takami

“…Uveal melanoma is the most common primary ocular malignancy in adults, characterized by gene mutations in G protein subunit alpha q ( ) and G protein subunit…”
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Split tolerance permits safe Ad5-GUCY2C-PADRE vaccine-induced T-cell responses in colon cancer patients by Snook, Adam E, Baybutt, Trevor R, Xiang, Bo, Abraham, Tara S, Flickinger, Jr, John C, Hyslop, Terry, Zhan, Tingting, Kraft, Walter K, Sato, Takami, Waldman, Scott A

“…The colorectal cancer antigen GUCY2C exhibits unique split tolerance, evoking antigen-specific CD8 , but not CD4 , T-cell responses that deliver anti-tumor…”
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Double-Blinded, Randomized Phase II Study Using Embolization with or without Granulocyte–Macrophage Colony-Stimulating Factor in Uveal Melanoma with Hepatic Metastases by Valsecchi, Matias E., MD, MS, Terai, Mizue, PhD, Eschelman, David J., MD, Gonsalves, Carin F., MD, Chervoneva, Inna, PhD, Shields, Jerry A., MD, Shields, Carol L., MD, Yamamoto, Akira, MD, Sullivan, Kevin L., MD, Laudadio, MaryAnn, RN, Berd, David, MD, Mastrangelo, Michael J., MD, Sato, Takami, MD, PhD

“…Abstract Purpose To investigate the effects of immunoembolization with granulocyte–macrophage colony-stimulating factor (GM-CSF) in patients with uveal…”
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Long-term survival follow-up for tebentafusp in previously treated metastatic uveal melanoma by Sacco, Joseph J, Carvajal, Richard D, Butler, Marcus O, Shoushtari, Alexander N, Hassel, Jessica C, Ikeguchi, Alexandra, Hernandez-Aya, Leonel, Nathan, Paul, Hamid, Omid, Piulats, Josep M, Rioth, Matthew, Johnson, Douglas B, Luke, Jason J, Espinosa, Enrique, Leyvraz, Serge, Collins, Laura, Holland, Chris, Sato, Takami

“…BackgroundTebentafusp, a bispecific (gp100×CD3) ImmTAC, significantly improved overall survival (OS) outcomes for HLA-A*02:01+ adult patients with untreated…”
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Characterizing metastatic uveal melanoma patients who develop symptomatic brain metastases by Wei, Alexander Z., Uriel, Matan, Porcu, Agata, Manos, Michael P., Mercurio, Ann C., Caplan, Michael M., Hulse, Liam, Seedor, Rino S., Holovatska, Marta, Francis, Jasmine, Khan, Shaheer A., McDonnell, Diana E., Bogomolny, Dmitry, Sato, Takami, Marr, Brian P., Haq, Rizwan, Orloff, Marlana, Shoushtari, Alexander, Carvajal, Richard D.

“…Metastatic uveal melanoma (mUM) is an advanced ocular malignancy characterized by a hepatotropic pattern of spread. As the incidence of brain metastases (BM)…”
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A cluster of Candida parapsilosis displaying fluconazole-trailing in a neonatal intensive care unit successfully contained by multiple infection-control interventions by Baba, Hiroaki, Kanamori, Hajime, Nakayama, Asami, Sato, Takami, Katsumi, Makoto, Chida, Takae, Ikeda, Shinobu, Seki, Rio, Arai, Teppei, Kamei, Katsuhiko, Tokuda, Koichi

“…This study aimed to investigate and contain a cluster of invasive candidiasis cases caused by fluconazole-resistant (FRC) in a neonatal intensive care unit…”
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Integrin receptors on tumor cells facilitate NK cell‐mediated antibody‐dependent cytotoxicity by Anikeeva, Nadia, Steblyanko, Maria, Fayngerts, Svetlana, Kopylova, Natalya, Marshall, Deborah J., Powers, Gordon D., Sato, Takami, Campbell, Kerry S., Sykulev, Yuri

“…NK cells that mediate ADCC play an important role in tumor‐specific immunity. We have examined factors limiting specific lysis of tumor cells by CD16.NK‐92…”
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