Search Results - "Sato, Aaron K"

Production of Site-Specific Antibody–Drug Conjugates Using Optimized Non-Natural Amino Acids in a Cell-Free Expression System by Zimmerman, Erik S, Heibeck, Tyler H, Gill, Avinash, Li, Xiaofan, Murray, Christopher J, Madlansacay, Mary Rose, Tran, Cuong, Uter, Nathan T, Yin, Gang, Rivers, Patrick J, Yam, Alice Y, Wang, Willie D, Steiner, Alexander R, Bajad, Sunil U, Penta, Kalyani, Yang, Wenjin, Hallam, Trevor J, Thanos, Christopher D, Sato, Aaron K

“…Antibody–drug conjugates (ADCs) are a targeted chemotherapeutic currently at the cutting edge of oncology medicine. These hybrid molecules consist of a tumor…”
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Discovery of a potent, selective, and tumor-suppressing antibody antagonist of adenosine A2A receptor by Wang, Linya, Garg, Pankaj, Chan, Kara Y, Yuan, Tom Z, Lujan Hernandez, Ana G, Han, Zhen, Peterson, Sean M, Tuscano, Emily, Safavi, Crystal, Kwan, Eric, Villalta, Mouna, Mathur, Melina, Lai, Joyce, Axelrod, Fumiko, Souders, Colby A, Emery, Chloe, Sato, Aaron K

“…New immune checkpoints are emerging in a bid to improve response rates to immunotherapeutic drugs. The adenosine A2A receptor (A2AR) has been proposed as a…”
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Discovery and design of G protein-coupled receptor targeting antibodies by Peterson, Sean M, Hutchings, Catherine J, Hu, Cameron F, Mathur, Melina, Salameh, Janelle W, Axelrod, Fumiko, Sato, Aaron K

“…G protein-coupled receptors (GPCRs) are the target of one-third of all approved drugs; however, these drugs only target about one-eighth of the human…”
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Rapid discovery of diverse neutralizing SARS-CoV-2 antibodies from large-scale synthetic phage libraries by Yuan, Tom Z, Garg, Pankaj, Wang, Linya, Willis, Jordan R, Kwan, Eric, Hernandez, Ana G Lujan, Tuscano, Emily, Sever, Emily N, Keane, Erica, Soto, Cinque, Mucker, Eric M, Fouch, Mallorie E, Davidson, Edgar, Doranz, Benjamin J, Kailasan, Shweta, Aman, M Javad, Li, Haoyang, Hooper, Jay W, Saphire, Erica Ollmann, Crowe, James E, Liu, Qiang, Axelrod, Fumiko, Sato, Aaron K

“…Coronavirus disease 2019 (COVID-19) is an evolving global public health crisis in need of therapeutic options. Passive immunization of monoclonal antibodies…”
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Functional GLP-1R antibodies identified from a synthetic GPCR-focused library demonstrate potent blood glucose control by Liu, Qiang, Garg, Pankaj, Hasdemir, Burcu, Wang, Linya, Tuscano, Emily, Sever, Emily, Keane, Erica, Hernandez, Ana G Lujan, Yuan, Tom Z, Kwan, Eric, Lai, Joyce, Szot, Greg, Paruthiyil, Sreenivasan, Axelrod, Fumiko, K Sato, Aaron

“…G protein-coupled receptors (GPCRs) are a group of seven-transmembrane receptor proteins that have proven to be successful drug targets. Antibodies are…”
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RF1 attenuation enables efficient non-natural amino acid incorporation for production of homogeneous antibody drug conjugates by Yin, Gang, Stephenson, Heather T., Yang, Junhao, Li, Xiaofan, Armstrong, Stephanie M., Heibeck, Tyler H., Tran, Cuong, Masikat, Mary Rose, Zhou, Sihong, Stafford, Ryan L., Yam, Alice Y., Lee, John, Steiner, Alexander R., Gill, Avinash, Penta, Kalyani, Pollitt, Sonia, Baliga, Ramesh, Murray, Christopher J., Thanos, Christopher D., McEvoy, Leslie M., Sato, Aaron K., Hallam, Trevor J.

“…Amber codon suppression for the insertion of non-natural amino acids (nnAAs) is limited by competition with release factor 1 (RF1). Here we describe the genome…”
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Engineering toward a bacterial "endoplasmic reticulum" for the rapid expression of immunoglobulin proteins by Groff, Dan, Armstrong, Stephanie, Rivers, Patrick J, Zhang, Juan, Yang, Junhao, Green, Evan, Rozzelle, James, Liang, Shengwen, Kittle, Joseph D, Steiner, Alexander R, Baliga, Ramesh, Thanos, Christopher D, Hallam, Trevor J, Sato, Aaron K, Yam, Alice Y

“…Antibodies are well-established as therapeutics, and the preclinical and clinical pipeline of these important biologics is growing rapidly. Consequently, there…”
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Post-Exposure Protection in Mice against Sudan Virus by a Two Antibody Cocktail by Froude, Jeffrey W, Herbert, Andrew S, Pelat, Thibaut, Miethe, Sebastian, Zak, Samantha E, Brannan, Jennifer M, Bakken, Russell R, Steiner, Alexander R, Yin, Gang, Hallam, Trevor J, Sato, Aaron K, Hust, Michael, Thullier, Philippe, Dye, John M

“…Sudan virus (SUDV) and Ebola viruses (EBOV) are both members of the genus and have been sources of epidemics and outbreaks for several decades. We present here…”
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Discovery of Fully Human Anti-MET Monoclonal Antibodies with Antitumor Activity against Colon Cancer Tumor Models In Vivo by van der Horst, Edward Htun, Chinn, Lawrence, Wang, Min, Velilla, Timothy, Tran, Hoang, Madrona, Yarrow, Lam, Andrew, Ji, May, Hoey, Timothy C., Sato, Aaron K.

“…The receptor tyrosine kinase MET is a major component controlling the invasive growth program in embryonic development and in invasive malignancies. The…”
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Phage display technology and its impact in the discovery of novel protein-based drugs by Hutchings, Catherine J, Sato, Aaron K

“…Phage display technology is a well-established versatile display technology that has been used for over 35 years to identify peptides and antibodies for use as…”
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Therapeutic peptides: technological advances driving peptides into development by Sato, Aaron K, Viswanathan, Malini, Kent, Rachel B, Wood, Clive R

“…As potential therapeutics, peptides offer several advantages over small molecules (increased specificity) and antibodies (small size). Nevertheless, a number…”
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Methods to Make Homogenous Antibody Drug Conjugates by Kline, Toni, Steiner, Alexander R., Penta, Kalyani, Sato, Aaron K., Hallam, Trevor J., Yin, Gang

“…Antibody drug conjugates (ADCs) have progressed from hypothesis to approved therapeutics in less than 30 years, and the technologies available to modify both…”
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Extracellular Antigen Processing and Presentation by Immature Dendritic Cells by Santambrogio, Laura, Sato, Aaron K., Carven, Gregory J., Belyanskaya, Svetlana L., Strominger, Jack L., Stern, Lawrence J.

“…In antigen presentation to CD4+T cells, proteins are degraded to peptide fragments and loaded onto class II MHC molecules in a process involving the peptide…”
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Identification of an ADAMTS-4 Cleavage Motif Using Phage Display Leads to the Development of Fluorogenic Peptide Substrates and Reveals Matrilin-3 as a Novel Substrate by Hills, Robert, Mazzarella, Richard, Fok, Kam, Liu, Min, Nemirovskiy, Olga, Leone, Joseph, Zack, Marc D., Arner, Elizabeth C., Viswanathan, Malini, Abujoub, Aida, Muruganandam, Arumugam, Sexton, Daniel J., Bassill, Gary J., Sato, Aaron K., Malfait, Anne-Marie, Tortorella, Micky D.

“…ADAMTS-4 and ADAMTS-5 are aggrecanases responsible for the breakdown of cartilage aggrecan in osteoarthritis. Multiple ADAMTS-4 cleavage sites have been…”
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Discovery of STRO-002, a Novel Homogeneous ADC Targeting Folate Receptor Alpha, for the Treatment of Ovarian and Endometrial Cancers by Li, Xiaofan, Zhou, Sihong, Abrahams, Cristina L, Krimm, Stellanie, Smith, Jennifer, Bajjuri, Krishna, Stephenson, Heather T, Henningsen, Robert, Hanson, Jeffrey, Heibeck, Tyler H, Calarese, Daniel, Tran, Cuong, Yin, Gang, Stafford, Ryan L, Yam, Alice Y, Kline, Toni, De Almeida, Venita I, Sato, Aaron K, Lupher, Mark, Bedard, Kristin, Hallam, Trevor J

“…STRO-002 is a novel homogeneous folate receptor alpha (FolRα) targeting antibody-drug conjugate (ADC) currently being investigated in the clinic as a treatment…”
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Abundant Empty Class II MHC Molecules on the Surface of Immature Dendritic Cells by Santambrogio, Laura, Sato, Aaron K., Fischer, Falko R., Dorf, Martin E., Stern, Lawrence J.

“…A monoclonal antibody specific for the empty conformation of class II MHC molecules revealed the presence of abundant empty molecules on the surface of spleen-…”
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Malaria Derived Glycosylphosphatidylinositol Anchor Enhances Anti-Pfs25 Functional Antibodies That Block Malaria Transmission by Kapoor, Neeraj, Vanjak, Ivana, Rozzelle, James, Berges, Aym, Chan, Wei, Yin, Gang, Tran, Cuong, Sato, Aaron K, Steiner, Alexander R, Pham, Thao P, Birkett, Ashley J, Long, Carole A, Fairman, Jeff, Miura, Kazutoyo

“…Malaria, one of the most common vector borne human diseases, is a major world health issue. In 2015 alone, more than 200 million people were infected with…”
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Optimization of a glucagon-like peptide 1 receptor antagonist antibody for treatment of hyperinsulinism by Peterson, Sean M, Juliana, Christine A, Hu, Cameron F, Chai, Jinghua, Holliday, Carson, Chan, Kara Y, Lujan Hernandez, Ana G, Challocombe, Zoe, Wang, Linya, Han, Zhen, Haas, Nikhil, Stafford, Ryan, Axelrod, Fumiko, Yuan, Tom Z, De Leόn, Diva D, Sato, Aaron K

“…Congenital hyperinsulinism (HI) is a genetic disorder in which pancreatic beta cell insulin secretion is excessive and results in hypoglycemia that can cause…”
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A simplified and robust protocol for immunoglobulin expression in Escherichia coli cell-free protein synthesis systems by Cai, Qi, Hanson, Jeffrey A., Steiner, Alexander R., Tran, Cuong, Masikat, Mary Rose, Chen, Rishard, Zawada, James F., Sato, Aaron K., Hallam, Trevor J., Yin, Gang

“…Cell‐free protein synthesis (CFPS) systems allow for robust protein expression with easy manipulation of conditions to improve protein yield and folding…”
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Toward a Ferrous Iron-Cleavable Linker for Antibody–Drug Conjugates by Spangler, Benjamin, Kline, Toni, Hanson, Jeffrey, Li, Xiaofan, Zhou, Sihong, Wells, James A, Sato, Aaron K, Renslo, Adam R

“…Antibody–drug conjugates (ADCs) are antigen-targeted therapeutics that employ antibodies to deliver potent, cytotoxic effectors to cells with potentially high…”
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