Search Results - "Satijn, David P. E."

DuoBody-CD40x4-1BB induces dendritic-cell maturation and enhances T-cell activation through conditional CD40 and 4-1BB agonist activity by Muik, Alexander, Adams III, Homer C, Gieseke, Friederike, Altintas, Isil, Schoedel, Kristina B, Blum, Jordan M, Sänger, Bianca, Burm, Saskia M, Stanganello, Eliana, Verzijl, Dennis, Spires, Vanessa M, Vascotto, Fulvia, Toker, Aras, Quinkhardt, Juliane, Fereshteh, Mark, Diken, Mustafa, Satijn, David P E, Kreiter, Sebastian, Ahmadi, Tahamtan, Breij, Esther C W, Türeci, Özlem, Sasser, Kate, Sahin, Ugur, Jure-Kunkel, Maria

“…BackgroundDespite the preclinical promise of CD40 and 4-1BB as immuno-oncology targets, clinical efforts evaluating CD40 and 4-1BB agonists as monotherapy have…”
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Cutting Edge: Polycomb Gene Expression Patterns Reflect Distinct B Cell Differentiation Stages in Human Germinal Centers by Raaphorst, Frank M, van Kemenade, Folkert J, Fieret, Elly, Hamer, Karien M, Satijn, David P. E, Otte, Arie P, Meijer, Chris J. L. M

“…Polycomb group (Pc-G) proteins regulate homeotic gene expression in Drosophila, mouse, and humans. Mouse Pc-G proteins are also essential for adult…”
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Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma by van Kemenade, Folkert J., Raaphorst, Frank M., Blokzijl, Tjasso, Fieret, Elly, Hamer, Karien M., Satijn, David P.E., Otte, Arie P., Meijer, Chris J.L.M.

“…Polycomb-group (PcG) proteins, such as BMI-1 and EZH2, form multimeric gene-repressing complexes involved in axial patterning, hematopoiesis, and cell cycle…”
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The Human Polycomb Group Complex Associates with Pericentromeric Heterochromatin to Form a Novel Nuclear Domain by Saurin, Andrew J., Shiels, Carol, Williamson, Jill, David P. E. Satijn, Otte, Arie P., Sheer, Denise, Freemont, Paul S.

“…The Polycomb group (PcG) complex is a chromatin-associated multiprotein complex, involved in the stable repression of homeotic gene activity in Drosophila…”
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Identification of anti-repressor elements that confer high and stable protein production in mammalian cells by Otte, Arie P, Kwaks, Ted H.J, Barnett, Phil, Hemrika, Wieger, Siersma, Tjalling, Sewalt, Richard G.A.B, Satijn, David P.E, Brons, Janynke F, van Blokland, Rik, Kwakman, Paul, Kruckeberg, Arle L, Kelder, Angèle

“…The expression of transgenic proteins is often low and unstable over time, a problem that may be due to integration of the transgene in repressed chromatin. We…”
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Characterization of Interactions between the Mammalian Polycomb-Group Proteins Enx1/EZH2 and EED Suggests the Existence of Different Mammalian Polycomb-Group Protein Complexes by Sewalt, Richard G. A. B., van der Vlag, Johan, Gunster, Marco J., Hamer, Karien M., den Blaauwen, Jan L., Satijn, David P. E., Hendrix, Thijs, van Driel, Roel, Otte, Arie P.

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C-Terminal Binding Protein Is a Transcriptional Repressor That Interacts with a Specific Class of Vertebrate Polycomb Proteins by Sewalt, Richard G. A. B., Gunster, Marco J., van der Vlag, Johan, Satijn, David P. E., Otte, Arie P.

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Coexpression of BMI-1 and EZH2 Polycomb Group Genes in Reed-Sternberg Cells of Hodgkin’s Disease by Raaphorst, Frank M., van Kemenade, Folkert J., Blokzijl, Tjasso, Fieret, Elly, Hamer, Karien M., Satijn, David P.E., Otte, Arie P., Meijer, Chris J.L.M.

“…The human BMI-1 and EZH2 polycomb group (PcG) proteins are constituents of two distinct complexes of PcG proteins with gene regulatory activity. PcG proteins…”
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RING1 Interacts with Multiple Polycomb-Group Proteins and Displays Tumorigenic Activity by Satijn, David P. E., Otte, Arie P.

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Distinct BMI-1 and EZH2 Expression Patterns in Thymocytes and Mature T Cells Suggest a Role for Polycomb Genes in Human T Cell Differentiation by Raaphorst, Frank M, Otte, Arie P, van Kemenade, Folkert J, Blokzijl, Tjasso, Fieret, Elly, Hamer, Karien M, Satijn, David P. E, Meijer, Chris J. L. M

“…BMI-1 and EZH2 Polycomb-group (PcG) proteins belong to two distinct protein complexes involved in the regulation of hematopoiesis. Using unique PcG-specific…”
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The Polycomb Group Protein EED Interacts with YY1, and Both Proteins Induce Neural Tissue in XenopusEmbryos by Satijn, David P. E., Hamer, Karien M., den Blaauwen, Jan, Otte, Arie P.

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An Fc-inert PD-L1×4-1BB bispecific antibody mediates potent anti-tumor immunity in mice by combining checkpoint inhibition and conditional 4-1BB co-stimulation by Muik, Alexander, Altintas, Isil, Gieseke, Friederike, Schoedel, Kristina B, Burm, Saskia M, Toker, Aras, Salcedo, Theodora W., Verzijl, Dennis, Eisel, David, Grunwitz, Christian, Kranz, Lena M, Vormehr, Mathias, Satijn, David P.E., Diken, Mustafa, Kreiter, Sebastian, Sasser, Kate, Ahmadi, Tahamtan, Türeci, Özlem, Breij, Esther C.W., Jure-Kunkel, Maria, Sahin, Ugur

“…Immune checkpoint inhibitors (ICI) targeting the PD-1/PD-L1 axis have changed the treatment paradigm for advanced solid tumors; however, many patients…”
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The polycomb group protein EED interacts with YY1, and both proteins induce neural tissue in Xenopus embryos by Satijn, D P, Hamer, K M, den Blaauwen, J, Otte, A P

“…Polycomb group (PcG) proteins form multimeric protein complexes which are involved in the heritable stable repression of genes. Previously, we identified two…”
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RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor by Satijn, David P. E., Gunster, Marco J., van der Vlag, Johan, Hamer, Karien M., Schul, Wouter, Alkema, Mark J., Saurin, Andrew J., Freemont, Paul S., van Driel, Roel, Otte, Arie P.

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A panel of monoclonal antibodies against human polycomb group proteins by Hamer, Karien M, Sewalt, Richard G A B, den Blaauwen, Jan L, Hendrix, Thijs, Satijn, David P E, Otte, Arie P

“…Polycomb-group (PcG) proteins are chromatin-associated proteins that heritably repress gene activity in many organisms, including man. Two distinct human PcG…”
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Interference with the expression of a novel human polycomb protein, hPc2, results in cellular transformation and apoptosis by Satijn, David P. E., Olson, Daniel J., van der Vlag, Johan, Hamer, Karien M., Lambrechts, Caro, Masselink, Hans, Gunster, Marco J., Sewalt, Richard G. A. B., van Driel, Roel, Otte, Arie P.

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Corrigenda: Identification of anti-repressor elements that confer high and stable protein production in mammalian cells by Ted HJ Kwaks, Barnett, Phil, Hemrika, Wieger, Siersma, Tjalling, Richard GAB Sewalt, David PE Satijn, Brons, Janynke F, Rik van Blokland, Kwakman, Paul, Kruckeberg, Arle, Ang? Kelder, Otte, Arie P

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Erratum: Identification of anti-repressor elements that confer high and stable protein production in mammalian cells by Kwaks, Ted HJ, Barnett, Phil, Hemrika, Wieger, Siersma, Tjalling, Sewalt, Richard GAB, Satijn, David PE, Brons, Janynke F, van Blokland, Rik, Kwakman, Paul, Kruckeberg, Arle, Kelder, Angèle, Otte, Arie P

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Identification of anti-repressor elements that confer high and stable protein production in mammalian cells by Kwaks, Ted HJ, Barnett, Phil, Hemrika, Wieger, Siersma, Tjalling, Sewalt, Richard GAB, Satijn, David PE, Brons, Janynke F, van Blokland, Rik, Kwakman, Paul, Kruckeberg, Arle, Kelder, Angèle, Otte, Arie P

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