Search Results - "Satijn, David"

Efficient Payload Delivery by a Bispecific Antibody-Drug Conjugate Targeting HER2 and CD63 by de Goeij, Bart E C G, Vink, Tom, Ten Napel, Hendrik, Breij, Esther C W, Satijn, David, Wubbolts, Richard, Miao, David, Parren, Paul W H I

“…Antibody-drug conjugates (ADC) are designed to be stable in circulation and to release potent cytotoxic drugs intracellularly following antigen-specific…”
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DuoBody-CD40x4-1BB induces dendritic-cell maturation and enhances T-cell activation through conditional CD40 and 4-1BB agonist activity by Muik, Alexander, Adams III, Homer C, Gieseke, Friederike, Altintas, Isil, Schoedel, Kristina B, Blum, Jordan M, Sänger, Bianca, Burm, Saskia M, Stanganello, Eliana, Verzijl, Dennis, Spires, Vanessa M, Vascotto, Fulvia, Toker, Aras, Quinkhardt, Juliane, Fereshteh, Mark, Diken, Mustafa, Satijn, David P E, Kreiter, Sebastian, Ahmadi, Tahamtan, Breij, Esther C W, Türeci, Özlem, Sasser, Kate, Sahin, Ugur, Jure-Kunkel, Maria

“…BackgroundDespite the preclinical promise of CD40 and 4-1BB as immuno-oncology targets, clinical efforts evaluating CD40 and 4-1BB agonists as monotherapy have…”
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High turnover of tissue factor enables efficient intracellular delivery of antibody-drug conjugates by de Goeij, Bart E C G, Satijn, David, Freitag, Claudia M, Wubbolts, Richard, Bleeker, Wim K, Khasanov, Alisher, Zhu, Tong, Chen, Gary, Miao, David, van Berkel, Patrick H C, Parren, Paul W H I

“…Antibody-drug conjugates (ADC) are emerging as powerful cancer treatments that combine antibody-mediated tumor targeting with the potent cytotoxic activity of…”
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An Fc-inert PD-L1×4-1BB bispecific antibody mediates potent anti-tumor immunity in mice by combining checkpoint inhibition and conditional 4-1BB co-stimulation by Muik, Alexander, Altintas, Isil, Gieseke, Friederike, Schoedel, Kristina B, Burm, Saskia M, Toker, Aras, Salcedo, Theodora W., Verzijl, Dennis, Eisel, David, Grunwitz, Christian, Kranz, Lena M, Vormehr, Mathias, Satijn, David P.E., Diken, Mustafa, Kreiter, Sebastian, Sasser, Kate, Ahmadi, Tahamtan, Türeci, Özlem, Breij, Esther C.W., Jure-Kunkel, Maria, Sahin, Ugur

“…Immune checkpoint inhibitors (ICI) targeting the PD-1/PD-L1 axis have changed the treatment paradigm for advanced solid tumors; however, many patients…”
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IL-8 as Antibody Therapeutic Target in Inflammatory Diseases: Reduction of Clinical Activity in Palmoplantar Pustulosis by Skov, Lone, Beurskens, Frank J, Zachariae, Claus O. C, Reitamo, Sakari, Teeling, Jessica, Satijn, David, Knudsen, Kim M, Boot, Elmieke P. J, Hudson, Debra, Baadsgaard, Ole, Parren, Paul W. H. I, van de Winkel, Jan G. J

“…IL-8 is a chemokine that has been implicated in a number of inflammatory diseases involving neutrophil activation. HuMab 10F8 is a novel fully human mAb…”
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Identification of anti-repressor elements that confer high and stable protein production in mammalian cells by Otte, Arie P, Kwaks, Ted H.J, Barnett, Phil, Hemrika, Wieger, Siersma, Tjalling, Sewalt, Richard G.A.B, Satijn, David P.E, Brons, Janynke F, van Blokland, Rik, Kwakman, Paul, Kruckeberg, Arle L, Kelder, Angèle

“…The expression of transgenic proteins is often low and unstable over time, a problem that may be due to integration of the transgene in repressed chromatin. We…”
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Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma by van Kemenade, Folkert J., Raaphorst, Frank M., Blokzijl, Tjasso, Fieret, Elly, Hamer, Karien M., Satijn, David P.E., Otte, Arie P., Meijer, Chris J.L.M.

“…Polycomb-group (PcG) proteins, such as BMI-1 and EZH2, form multimeric gene-repressing complexes involved in axial patterning, hematopoiesis, and cell cycle…”
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Coexpression of BMI-1 and EZH2 Polycomb Group Genes in Reed-Sternberg Cells of Hodgkin’s Disease by Raaphorst, Frank M., van Kemenade, Folkert J., Blokzijl, Tjasso, Fieret, Elly, Hamer, Karien M., Satijn, David P.E., Otte, Arie P., Meijer, Chris J.L.M.

“…The human BMI-1 and EZH2 polycomb group (PcG) proteins are constituents of two distinct complexes of PcG proteins with gene regulatory activity. PcG proteins…”
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704 Preclinical mechanism of action and pharmacodynamic biomarker studies of DuoBody®-CD3x5T4 in vitro and in vivo in solid cancer models by Kemper, Kristel, Gielen, Ellis, Houtkamp, Mischa, Boross, Peter, Burm, Saskia, Poot, Stefanie De, Engelberts, Patrick, Goeij, Bart de, Satijn, David, Sasser, Kate, Breij, Esther

“…BackgroundThe tumor-associated antigen 5T4 is expressed across a wide range of solid cancers. DuoBody-CD3x5T4 is a bispecific antibody (bsAb) that crosslinks…”
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The Human Polycomb Group Complex Associates with Pericentromeric Heterochromatin to Form a Novel Nuclear Domain by Saurin, Andrew J., Shiels, Carol, Williamson, Jill, David P. E. Satijn, Otte, Arie P., Sheer, Denise, Freemont, Paul S.

“…The Polycomb group (PcG) complex is a chromatin-associated multiprotein complex, involved in the stable repression of homeotic gene activity in Drosophila…”
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Characterization of Interactions between the Mammalian Polycomb-Group Proteins Enx1/EZH2 and EED Suggests the Existence of Different Mammalian Polycomb-Group Protein Complexes by Sewalt, Richard G. A. B., van der Vlag, Johan, Gunster, Marco J., Hamer, Karien M., den Blaauwen, Jan L., Satijn, David P. E., Hendrix, Thijs, van Driel, Roel, Otte, Arie P.

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C-Terminal Binding Protein Is a Transcriptional Repressor That Interacts with a Specific Class of Vertebrate Polycomb Proteins by Sewalt, Richard G. A. B., Gunster, Marco J., van der Vlag, Johan, Satijn, David P. E., Otte, Arie P.

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RING1 Interacts with Multiple Polycomb-Group Proteins and Displays Tumorigenic Activity by Satijn, David P. E., Otte, Arie P.

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Cutting Edge: Polycomb Gene Expression Patterns Reflect Distinct B Cell Differentiation Stages in Human Germinal Centers by Raaphorst, Frank M, van Kemenade, Folkert J, Fieret, Elly, Hamer, Karien M, Satijn, David P. E, Otte, Arie P, Meijer, Chris J. L. M

“…Polycomb group (Pc-G) proteins regulate homeotic gene expression in Drosophila, mouse, and humans. Mouse Pc-G proteins are also essential for adult…”
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Distinct BMI-1 and EZH2 Expression Patterns in Thymocytes and Mature T Cells Suggest a Role for Polycomb Genes in Human T Cell Differentiation by Raaphorst, Frank M, Otte, Arie P, van Kemenade, Folkert J, Blokzijl, Tjasso, Fieret, Elly, Hamer, Karien M, Satijn, David P. E, Meijer, Chris J. L. M

“…BMI-1 and EZH2 Polycomb-group (PcG) proteins belong to two distinct protein complexes involved in the regulation of hematopoiesis. Using unique PcG-specific…”
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Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic by Gunster, Marco J., Satijn, David P., Hamer, Karien M., Blaauwen, Jan L. den, Bruijn, Diederik de, Alkema, Mark J., Lohuizen, Maarten van, Driel, Roel van, Otte, Arie P.

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Ring1A is a transcriptional repressor that interacts with the Polycomb-M33 protein and is expressed at rhombomere boundaries in the mouse hindbrain by Schoorlemmer, Jon, Marcos-Gutiérrez, Camelia, Were, Felipe, Martínez, Rodrigo, García, Emiliano, Satijn, David P.E., Otte, Arie P., Vidal, Miguel

“…In Drosophila, the products of the Polycomb group (Pc‐G) of genes act as chromatin‐associated multimeric protein complexes that repress expression of homeotic…”
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RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor by Satijn, David P. E., Gunster, Marco J., van der Vlag, Johan, Hamer, Karien M., Schul, Wouter, Alkema, Mark J., Saurin, Andrew J., Freemont, Paul S., van Driel, Roel, Otte, Arie P.

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Interference with the expression of a novel human polycomb protein, hPc2, results in cellular transformation and apoptosis by Satijn, David P. E., Olson, Daniel J., van der Vlag, Johan, Hamer, Karien M., Lambrechts, Caro, Masselink, Hans, Gunster, Marco J., Sewalt, Richard G. A. B., van Driel, Roel, Otte, Arie P.

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Assessment of Ultra-Deep Mass Spectrometry Based Proteomics Compared to Flow Cytometry and RNA-Based Methods for the Discovery and Validation of Therapeutic Targets in Immune Cells by Au, Yu-Wah, Rigter, Gemma, Yu, Wingyan, Satijn, David, Mehnert, Martin, Lachaud, Amaury, Vowinckel, Jakob, Neijssen, Joost, Bon, Helene

“…Immuno-oncology (IO) has substantially improved the survival of cancer patients over the past several years encouraging the discovery of novel IO targets which…”
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