Role of pyroptosis in liver diseases

•Pyroptosis is known as programmed cell death.•There are two types of signaling pathways, such as caspase-1, and caspase-4/5/11 mediated pathways, involved in pyroptosis.•Pyroptosis plays crucial roles in the pathogenesis and progression of various liver diseases.•NLRP3 inflammasome inhibitors can m...

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Bibliographic Details
Published in:	International immunopharmacology Vol. 84; p. 106489
Main Authors:	Al Mamun, Abdullah, Wu, Yanqing, Jia, Chang, Munir, Fahad, Sathy, Kasfia Jahan, Sarker, Tamanna, Monalisa, Ilma, Zhou, Kailiang, Xiao, Jian
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-07-2020 Elsevier BV
Subjects:	Animals Apoptosis Caspase-1 Caspase-1, liver diseases Caspase-4 Caspases - metabolism Cell death Cytokines Humans Immune system Inflammasomes - metabolism Inflammation Intracellular Signaling Peptides and Proteins - metabolism Intracellular signalling Liver Liver diseases Liver Diseases - drug therapy Liver Diseases - etiology Liver Diseases - metabolism Liver Diseases - pathology Lysis NLR Family, Pyrin Domain-Containing 3 Protein - metabolism NLRP3 Non-alcoholic fatty liver disease Phosphate-Binding Proteins - metabolism Pore formation Pyroptosis Pyroptosis - physiology Caspase-1, liver diseases NLRP3 Pyroptosis Non-alcoholic fatty liver disease
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Summary:	•Pyroptosis is known as programmed cell death.•There are two types of signaling pathways, such as caspase-1, and caspase-4/5/11 mediated pathways, involved in pyroptosis.•Pyroptosis plays crucial roles in the pathogenesis and progression of various liver diseases.•NLRP3 inflammasome inhibitors can markedly inhibit pyroptosis, which can prevent the liver diseases.•So, Targeting pyroptosis can be a new potential therapeutic target for the treatment of liver diseases in the near future. Pyroptosis is known as a novel form of pro-inflammatory cell death program, which is exceptional from other types of cell death programs. Particularly, pyroptosis is characterized by Gasdermin family-mediated pore formation and subsequently cellular lysis, also release of several pro-inflammatory intracellular cytokines. In terms of mechanism, there are two signaling pathways involved in pyroptosis, including caspase-1, and caspase-4/5/11 mediated pathways. However, pyroptosis plays important roles in immune defense mechanisms. Recent studies have demonstrated that pyroptosis plays significant roles in the development of liver diseases. In our review, we have focused on the role of pyroptosis based on the molecular and pathophysiological mechanisms in the development of liver diseases. We have also highlighted targeting of pyroptosis for the therapeutic implications in liver diseases in the near future.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1567-5769 1878-1705
DOI:	10.1016/j.intimp.2020.106489