Search Results - "Sathirapongsasuti, J. Fah"

Microbial co-occurrence relationships in the human microbiome by Faust, Karoline, Sathirapongsasuti, J Fah, Izard, Jacques, Segata, Nicola, Gevers, Dirk, Raes, Jeroen, Huttenhower, Curtis

“…The healthy microbiota show remarkable variability within and among individuals. In addition to external exposures, ecological relationships (both oppositional…”
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Genome wide analysis for mouth ulcers identifies associations at immune regulatory loci by Dudding, Tom, Haworth, Simon, Lind, Penelope A., Sathirapongsasuti, J. Fah, Tung, Joyce Y., Mitchell, Ruth, Colodro-Conde, Lucía, Medland, Sarah E., Gordon, Scott, Elsworth, Benjamin, Paternoster, Lavinia, Franks, Paul W., Thomas, Steven J., Martin, Nicholas G., Timpson, Nicholas J.

“…Mouth ulcers are the most common ulcerative condition and encompass several clinical diagnoses, including recurrent aphthous stomatitis (RAS). Despite previous…”
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Genetic determinants of daytime napping and effects on cardiometabolic health by Dashti, Hassan S., Daghlas, Iyas, Lane, Jacqueline M., Huang, Yunru, Udler, Miriam S., Wang, Heming, Ollila, Hanna M., Jones, Samuel E., Kim, Jaegil, Wood, Andrew R., Weedon, Michael N., Aslibekyan, Stella, Garaulet, Marta, Saxena, Richa

“…Daytime napping is a common, heritable behavior, but its genetic basis and causal relationship with cardiometabolic health remain unclear. Here, we perform a…”
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Characterization of Prevalence and Health Consequences of Uniparental Disomy in Four Million Individuals from the General Population by Nakka, Priyanka, Pattillo Smith, Samuel, O’Donnell-Luria, Anne H., McManus, Kimberly F., Agee, Michelle, Auton, Adam, Bell, Robert K., Bryc, Katarzyna, Elson, Sarah L., Fontanillas, Pierre, Furlotte, Nicholas A., Hicks, Barry, Hinds, David A., Jewett, Ethan M., Jiang, Yunxuan, Lin, Keng-Han, McCreight, Jennifer C., Huber, Karen E., Kleinman, Aaron, Litterman, Nadia K., McIntyre, Matthew H., Noblin, Elizabeth S., Northover, Carrie A.M., Pitts, Steven J., Poznik, G. David, Shelton, Janie F., Shringarpure, Suyash, Tian, Chao, Tung, Joyce Y., Vacic, Vladimir, Wang, Xin, Mountain, Joanna L., Ramachandran, Sohini, Sathirapongsasuti, J. Fah

“…Meiotic nondisjunction and resulting aneuploidy can lead to severe health consequences in humans. Aneuploidy rescue can restore euploidy but may result in…”
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Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum by Fejzo, Marlena S., Sazonova, Olga V., Sathirapongsasuti, J. Fah, Hallgrímsdóttir, Ingileif B., Vacic, Vladimir, MacGibbon, Kimber W., Schoenberg, Frederic P., Mancuso, Nicholas, Slamon, Dennis J., Mullin, Patrick M.

“…Hyperemesis gravidarum (HG), severe nausea and vomiting of pregnancy, occurs in 0.3–2% of pregnancies and is associated with maternal and fetal morbidity. The…”
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Disease risk scores for skin cancers by Fontanillas, Pierre, Alipanahi, Babak, Furlotte, Nicholas A., Johnson, Michaela, Wilson, Catherine H., Pitts, Steven J., Gentleman, Robert, Auton, Adam

“…We trained and validated risk prediction models for the three major types of skin cancer— basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and…”
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Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction by Lam, Hilaire C, Cloonan, Suzanne M, Bhashyam, Abhiram R, Haspel, Jeffery A, Singh, Anju, Sathirapongsasuti, J Fah, Cervo, Morgan, Yao, Hongwei, Chung, Anna L, Mizumura, Kenji, An, Chang Hyeok, Shan, Bin, Franks, Jonathan M, Haley, Kathleen J, Owen, Caroline A, Tesfaigzi, Yohannes, Washko, George R, Quackenbush, John, Silverman, Edwin K, Rahman, Irfan, Kim, Hong Pyo, Mahmood, Ashfaq, Biswal, Shyam S, Ryter, Stefan W, Choi, Augustine M K

“…Chronic obstructive pulmonary disease (COPD) involves aberrant airway inflammatory responses to cigarette smoke (CS) that are associated with epithelial cell…”
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Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2 by Suryamohan, Kushal, Diwanji, Devan, Stawiski, Eric W., Gupta, Ravi, Miersch, Shane, Liu, Jiang, Chen, Chao, Jiang, Ying-Ping, Fellouse, Frederic A., Sathirapongsasuti, J. Fah, Albers, Patrick K., Deepak, Tanneeru, Saberianfar, Reza, Ratan, Aakrosh, Washburn, Gavin, Mis, Monika, Santhosh, Devi, Somasekar, Sneha, Hiranjith, G. H., Vargas, Derek, Mohan, Sangeetha, Phalke, Sameer, Kuriakose, Boney, Antony, Aju, Ustav Jr, Mart, Schuster, Stephan C., Sidhu, Sachdev, Junutula, Jagath R., Jura, Natalia, Seshagiri, Somasekar

“…COVID-19 is a respiratory illness caused by a novel coronavirus called SARS-CoV-2. The viral spike (S) protein engages the human angiotensin-converting enzyme…”
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Response to Comment on "Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior" by Ganna, Andrea, Verweij, Karin J H, Nivard, Michel G, Maier, Robert, Wedow, Robbee, Busch, Alexander S, Abdellaoui, Abdel, Guo, Shengru, Sathirapongsasuti, J Fah, Lichtenstein, Paul, Lundström, Sebastian, Långström, Niklas, Auton, Adam, Harris, Kathleen Mullan, Beecham, Gary W, Martin, Eden R, Sanders, Alan R, Perry, John R B, Neale, Benjamin M, Zietsch, Brendan P

“…Hamer argue that the variable "ever versus never had a same-sex partner" does not capture the complexity of human sexuality. We agree and said so in our paper…”
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Genome-wide association studies of antidepressant class response and treatment-resistant depression by Li, Qingqin S., Tian, Chao, Hinds, David

“…The “antidepressant efficacy” survey (AES) was deployed to > 50,000 23andMe, Inc. research participants to investigate the genetic basis of treatment-resistant…”
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Ultraconserved cDNA segments in the human transcriptome exhibit resistance to folding and implicate function in translation and alternative splicing by Sathirapongsasuti, J Fah, Sathira, Nuankanya, Suzuki, Yutaka, Huttenhower, Curtis, Sugano, Sumio

“…Ultraconservation, defined as perfect human-to-rodent sequence identity at least 200-bp long, is a strong indicator of evolutionary and functional importance…”
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Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways by Nagel, Mats, Jansen, Philip R., Stringer, Sven, Watanabe, Kyoko, de Leeuw, Christiaan A., Bryois, Julien, Savage, Jeanne E., Hammerschlag, Anke R., Skene, Nathan G., Muñoz-Manchado, Ana B., White, Tonya, Tiemeier, Henning, Linnarsson, Sten, Hjerling-Leffler, Jens, Polderman, Tinca J. C., Sullivan, Patrick F., van der Sluis, Sophie, Posthuma, Danielle

“…Neuroticism is an important risk factor for psychiatric traits, including depression 1 , anxiety 2 , 3 , and schizophrenia 4 – 6 . At the time of analysis,…”
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Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways by Howard, David M., Adams, Mark J., Shirali, Masoud, Clarke, Toni-Kim, Marioni, Riccardo E., Davies, Gail, Coleman, Jonathan R. I., Alloza, Clara, Shen, Xueyi, Barbu, Miruna C., Wigmore, Eleanor M., Gibson, Jude, Hagenaars, Saskia P., Lewis, Cathryn M., Ward, Joey, Smith, Daniel J., Sullivan, Patrick F., Haley, Chris S., Breen, Gerome, Deary, Ian J., McIntosh, Andrew M.

“…Depression is a polygenic trait that causes extensive periods of disability. Previous genetic studies have identified common risk variants which have…”
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Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior by Ganna, Andrea, Verweij, Karin J H, Nivard, Michel G, Maier, Robert, Wedow, Robbee, Busch, Alexander S, Abdellaoui, Abdel, Guo, Shengru, Sathirapongsasuti, J Fah, Lichtenstein, Paul, Lundström, Sebastian, Långström, Niklas, Auton, Adam, Harris, Kathleen Mullan, Beecham, Gary W, Martin, Eden R, Sanders, Alan R, Perry, John R B, Neale, Benjamin M, Zietsch, Brendan P

“…Twin and family studies have shown that same-sex sexual behavior is partly genetically influenced, but previous searches for specific genes involved have been…”
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Genetic analyses identify widespread sex-differential participation bias by Pirastu, Nicola, Cordioli, Mattia, Nandakumar, Priyanka, Mignogna, Gianmarco, Abdellaoui, Abdel, Hollis, Benjamin, Kanai, Masahiro, Rajagopal, Veera M., Parolo, Pietro Della Briotta, Baya, Nikolas, Carey, Caitlin E., Karjalainen, Juha, Als, Thomas D., Van der Zee, Matthijs D., Day, Felix R., Ong, Ken K., Morisaki, Takayuki, de Geus, Eco, Bellocco, Rino, Okada, Yukinori, Børglum, Anders D., Joshi, Peter, Auton, Adam, Hinds, David, Neale, Benjamin M., Walters, Raymond K., Nivard, Michel G., Perry, John R. B., Ganna, Andrea

“…Genetic association results are often interpreted with the assumption that study participation does not affect downstream analyses. Understanding the genetic…”
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Quantifying prion disease penetrance using large population control cohorts by Minikel, Eric Vallabh, Vallabh, Sonia M, Lek, Monkol, Estrada, Karol, Samocha, Kaitlin E, Sathirapongsasuti, J Fah, McLean, Cory Y, Tung, Joyce Y, Yu, Linda P C, Gambetti, Pierluigi, Blevins, Janis, Zhang, Shulin, Cohen, Yvonne, Chen, Wei, Yamada, Masahito, Hamaguchi, Tsuyoshi, Sanjo, Nobuo, Mizusawa, Hidehiro, Nakamura, Yosikazu, Kitamoto, Tetsuyuki, Collins, Steven J, Boyd, Alison, Will, Robert G, Knight, Richard, Ponto, Claudia, Zerr, Inga, Kraus, Theo F J, Eigenbrod, Sabina, Giese, Armin, Calero, Miguel, de Pedro-Cuesta, Jesús, Haïk, Stéphane, Laplanche, Jean-Louis, Bouaziz-Amar, Elodie, Brandel, Jean-Philippe, Capellari, Sabina, Parchi, Piero, Poleggi, Anna, Ladogana, Anna, O'Donnell-Luria, Anne H, Karczewski, Konrad J, Marshall, Jamie L, Boehnke, Michael, Laakso, Markku, Mohlke, Karen L, Kähler, Anna, Chambert, Kimberly, McCarroll, Steven, Sullivan, Patrick F, Hultman, Christina M, Purcell, Shaun M, Sklar, Pamela, van der Lee, Sven J, Rozemuller, Annemieke, Jansen, Casper, Hofman, Albert, Kraaij, Robert, van Rooij, Jeroen G J, Ikram, M Arfan, Uitterlinden, André G, van Duijn, Cornelia M, Daly, Mark J, MacArthur, Daniel G

“…More than 100,000 genetic variants are reported to cause Mendelian disease in humans, but the penetrance-the probability that a carrier of the purported…”
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Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis by Gallagher, C. S., Mäkinen, N., Harris, H. R., Rahmioglu, N., Uimari, O., Cook, J. P., Shigesi, N., Ferreira, T., Velez-Edwards, D. R., Edwards, T. L., Mortlock, S., Ruhioglu, Z., Day, F., Becker, C. M., Karhunen, V., Martikainen, H., Järvelin, M.-R., Cantor, R. M., Ridker, P. M., Terry, K. L., Buring, J. E., Gordon, S. D., Medland, S. E., Montgomery, G. W., Nyholt, D. R., Hinds, D. A., Tung, J. Y., Perry, J. R. B., Lind, P. A., Painter, J. N., Martin, N. G., Morris, A. P., Chasman, D. I., Missmer, S. A., Zondervan, K. T., Morton, C. C.

“…Uterine leiomyomata (UL) are the most common neoplasms of the female reproductive tract and primary cause for hysterectomy, leading to considerable morbidity…”
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Incorporating functional priors improves polygenic prediction accuracy in UK Biobank and 23andMe data sets by Márquez-Luna, Carla, Gazal, Steven, Loh, Po-Ru, Kim, Samuel S., Furlotte, Nicholas, Auton, Adam, Price, Alkes L.

“…Polygenic risk prediction is a widely investigated topic because of its promising clinical applications. Genetic variants in functional regions of the genome…”
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Genome-wide association and multi-omic analyses reveal ACTN2 as a gene linked to heart failure by Arvanitis, Marios, Tampakakis, Emmanouil, Zhang, Yanxiao, Wang, Wei, Auton, Adam, Dutta, Diptavo, Glavaris, Stephanie, Keramati, Ali, Chatterjee, Nilanjan, Chi, Neil C., Ren, Bing, Post, Wendy S., Battle, Alexis

“…Heart failure is a major public health problem affecting over 23 million people worldwide. In this study, we present the results of a large scale meta-analysis…”
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Genetic analysis of endometriosis and depression identifies shared loci and implicates causal links with gastric mucosa abnormality by Adewuyi, Emmanuel O., Mehta, Divya, Sapkota, Yadav, Auta, Asa, Yoshihara, Kosuke, Nyegaard, Mette, Griffiths, Lyn R., Montgomery, Grant W., Chasman, Daniel I., Nyholt, Dale R.

“…Evidence from observational studies indicates that endometriosis and depression often co-occur. However, conflicting evidence exists, and the etiology as well…”
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