Search Results - "Sather, William A"

Regulation of voltage-gated calcium channels by the ER calcium sensor STIM1 by Sather, William A, Dittmer, Philip J

“…•Key in stores-operated Ca2+ entry, STIM1 also controls voltage-gated Ca2+ channels.•STIM1, sensing a drop in ER Ca2+, binds and inhibits voltage-gated Ca2+…”
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AKAP-Anchored PKA Maintains Neuronal L-type Calcium Channel Activity and NFAT Transcriptional Signaling by Murphy, Jonathan G., Sanderson, Jennifer L., Gorski, Jessica A., Scott, John D., Catterall, William A., Sather, William A., Dell’Acqua, Mark L.

“…L-type voltage-gated Ca2+ channels (LTCC) couple neuronal excitation to gene transcription. LTCC activity is elevated by the cyclic AMP (cAMP)-dependent…”
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STIM1 Ca2+ Sensor Control of L-type Ca2+-Channel-Dependent Dendritic Spine Structural Plasticity and Nuclear Signaling by Dittmer, Philip J., Wild, Angela R., Dell’Acqua, Mark L., Sather, William A.

“…Potentiation of synaptic strength relies on postsynaptic Ca2+ signals, modification of dendritic spine structure, and changes in gene expression. One Ca2+…”
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AKAP79/150 anchoring of calcineurin controls neuronal L-type Ca2+ channel activity and nuclear signaling by Oliveria, Seth F, Dell'Acqua, Mark L, Sather, William A

“…Neuronal L-type calcium channels contribute to dendritic excitability and activity-dependent changes in gene expression that influence synaptic strength…”
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Synapse-to-Nucleus Communication through NFAT Is Mediated by L-type Ca2+ Channel Ca2+ Spike Propagation to the Soma by Wild, Angela R., Sinnen, Brooke L., Dittmer, Philip J., Kennedy, Matthew J., Sather, William A., Dell’Acqua, Mark L.

“…Long-term information storage in the brain requires continual modification of the neuronal transcriptome. Synaptic inputs located hundreds of micrometers from…”
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AKAP79/150 recruits the transcription factor NFAT to regulate signaling to the nucleus by neuronal L-type Ca2+ channels by Murphy, Jonathan G, Crosby, Kevin C, Dittmer, Philip J, Sather, William A, Dell'Acqua, Mark L

“…In neurons, regulation of activity-dependent transcription by the nuclear factor of activated T-cells (NFAT) depends upon Ca 2+ influx through voltage-gated…”
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Synaptic crosstalk conferred by a zone of differentially regulated Ca2+ signaling in the dendritic shaft adjoining a potentiated spine by Dittmer, Philip J., Dell’Acqua, Mark L., Sather, William A.

“…Patterns of postsynaptic activity that induce long-term potentiation of fast excitatory transmission at glutamatergic synapses between hippocampal neurons…”
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Ca2+/Calcineurin-Dependent Inactivation of Neuronal L-Type Ca2+ Channels Requires Priming by AKAP-Anchored Protein Kinase A by Dittmer, Philip J., Dell’Acqua, Mark L., Sather, William A.

“…Within neurons, Ca2+-dependent inactivation (CDI) of voltage-gated L-type Ca2+ channels shapes cytoplasmic Ca2+ signals. CDI is initiated by Ca2+ binding to…”
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Localized calcineurin confers Ca2+-dependent inactivation on neuronal L-type Ca2+ channels by Oliveria, Seth F, Dittmer, Philip J, Youn, Dong-ho, Dell'Acqua, Mark L, Sather, William A

“…Excitation-driven entry of Ca(2+) through L-type voltage-gated Ca(2+) channels controls gene expression in neurons and a variety of fundamental activities in…”
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Permeation and selectivity in calcium channels by Sather, William A, McCleskey, Edwin W

“…Recent advances-both experimental and theoretical-provide a tentative image of the structures in Ca channels that make them exceptionally selective. The image…”
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STIM1 Ca 2+ Sensor Control of L-type Ca 2+ -Channel-Dependent Dendritic Spine Structural Plasticity and Nuclear Signaling by Dittmer, Philip J, Wild, Angela R, Dell'Acqua, Mark L, Sather, William A

“…Potentiation of synaptic strength relies on postsynaptic Ca signals, modification of dendritic spine structure, and changes in gene expression. One Ca…”
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Afterhyperpolarization Regulates Firing Rate in Neurons of the Suprachiasmatic Nucleus by Cloues, Robin K, Sather, William A

“…Cluster I neurons of the suprachiasmatic nucleus (SCN), which are thought to be pacemakers supporting circadian activity, fire spontaneous action potentials…”
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Ionotropic Glutamate Receptors and Voltage-Gated Ca2+ Channels in Long-Term Potentiation of Spinal Dorsal Horn Synapses and Pain Hypersensitivity by Youn, Dong-ho, Gerber, Gábor, Sather, William A.

“…Over the last twenty years of research on cellular mechanisms of pain hypersensitivity, long-term potentiation (LTP) of synaptic transmission in the spinal…”
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Ion Channel Modulation in Spinal/Trigeminal Synaptic Plasticity by Youn, Dong-ho, Gerber, Gábor, Sather, William A.

“…Short-term and long-term modulation of the properties of these ion channels provide mechanisms for neural plasticity and changes in gene expression that can in…”
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Stac Proteins Suppress Ca2+-Dependent Inactivation of Neuronal l-type Ca2+ Channels by Polster, Alexander, Dittmer, Philip J, Perni, Stefano, Bichraoui, Hicham, Sather, William A, Beam, Kurt G

“…Stac protein (named for its SH3- and cysteine-rich domains) was first identified in brain 20 years ago and is currently known to have three isoforms. Stac2,…”
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Synaptic crosstalk conferred by a zone of differentially regulated Ca 2+ signaling in the dendritic shaft adjoining a potentiated spine by Dittmer, Philip J, Dell'Acqua, Mark L, Sather, William A

“…Patterns of postsynaptic activity that induce long-term potentiation of fast excitatory transmission at glutamatergic synapses between hippocampal neurons…”
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Stac Proteins Suppress Ca 2+ -Dependent Inactivation of Neuronal l-type Ca 2+ Channels by Polster, Alexander, Dittmer, Philip J, Perni, Stefano, Bichraoui, Hicham, Sather, William A, Beam, Kurt G

“…Stac protein (named for its SH3- and cysteine-rich domains) was first identified in brain 20 years ago and is currently known to have three isoforms. Stac2,…”
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AKAP79/150 recruits the transcription factor NFAT to regulate signaling to the nucleus by neuronal L-type Ca 2+ channels by Murphy, Jonathan G, Crosby, Kevin C, Dittmer, Philip J, Sather, William A, Dell'Acqua, Mark L

“…In neurons, regulation of activity-dependent transcription by the nuclear factor of activated T-cells (NFAT) depends upon Ca influx through voltage-gated…”
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Control of ion conduction in L-type Ca2+ channels by the concerted action of S5-6 regions by Cibulsky, Susan M, Sather, William A

“…Voltage-gated L-type Ca(2+) channels from cardiac (alpha(1C)) and skeletal (alpha(1S)) muscle differ from one another in ion selectivity and permeation…”
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A novel substituted aminoquinoline selectively targets voltage-sensitive sodium channel isoforms and NMDA receptor subtypes and alleviates chronic inflammatory and neuropathic pain by Tabakoff, Boris, Ren, Wenhua, Vanderlinden, Lauren, Snell, Lawrence D., Matheson, Christopher J., Wang, Ze-Jun, Levinson, Rock, Smothers, C. Thetford, Woodward, John J., Honse, Yumiko, Lovinger, David, Rush, Anthony M., Sather, William A., Gustafson, Daniel L., Hoffman, Paula L.

“…Recent understanding of the systems that mediate complex disease states, has generated a search for molecules that simultaneously modulate more than one…”
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