Search Results - "Sathe, Abhishek G."

A pharmacokinetic simulation study to assess the performance of a sparse blood sampling approach to quantify early drug exposure by Sathe, Abhishek G., Brundage, Richard C., Ivaturi, Vijay, Cloyd, James C., Chamberlain, James M., Elm, Jordan J., Silbergleit, Robert, Kapur, Jaideep, Coles, Lisa D.

“…Estimating early exposure of drugs used for the treatment of emergent conditions is challenging because blood sampling to measure concentrations is difficult…”
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Quantitative Assessment of Occipital Metabolic and Energetic Changes in Parkinson’s Patients, Using In Vivo 31P MRS-Based Metabolic Imaging at 7T by Zhu, Xiao-Hong, Lee, Byeong-Yeul, Tuite, Paul, Coles, Lisa, Sathe, Abhishek G., Chen, Chi, Cloyd, Jim, Low, Walter C., Steer, Clifford J., Chen, Wei

“…Abnormal energy metabolism associated with mitochondrial dysfunction is thought to be a major contributor to the progression of neurodegenerative diseases such…”
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Exposure–Response Analyses of Sacituzumab Govitecan Efficacy and Safety in Patients With Metastatic Triple‐Negative Breast Cancer by Sathe, Abhishek G., Diderichsen, Paul M., Fauchet, Floris, Phan, See‐Chun, Girish, Sandhya, Othman, Ahmed A.

“…Sacituzumab govitecan (SG), a Trop‐2‐directed antibody‐drug conjugate, is approved for patients with metastatic triple‐negative breast cancer (mTNBC) who…”
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Patterns of benzodiazepine underdosing in the Established Status Epilepticus Treatment Trial by Sathe, Abhishek G., Underwood, Ellen, Coles, Lisa D., Elm, Jordan J., Silbergleit, Robert, Chamberlain, James M., Kapur, Jaideep, Cock, Hannah R., Fountain, Nathan B., Shinnar, Shlomo, Lowenstein, Daniel H., Rosenthal, Eric S., Conwit, Robin A., Bleck, Thomas P., Cloyd, James C.

“…Objective This study was undertaken to describe patterns of benzodiazepine use as first‐line treatment of status epilepticus (SE) and test the association of…”
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Population Pharmacokinetics of Sacituzumab Govitecan in Patients with Metastatic Triple-Negative Breast Cancer and Other Solid Tumors by Sathe, Abhishek G., Singh, Indrajeet, Singh, Pratap, Diderichsen, Paul M., Wang, Xiaohui, Chang, Peter, Taqui, Atiya, Phan, See, Girish, Sandhya, Othman, Ahmed A.

“…Background and Objective Sacituzumab govitecan (SG) is an antibody–drug conjugate composed of an antibody with affinity for Trop-2 coupled to SN-38 via…”
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Underdosing of Benzodiazepines in Patients With Status Epilepticus Enrolled in Established Status Epilepticus Treatment Trial by Sathe, Abhishek G., Tillman, Holly, Coles, Lisa D., Elm, Jordan J., Silbergleit, Robert, Chamberlain, James, Kapur, Jaideep, Cock, Hannah R., Fountain, Nathan B., Shinnar, Shlomo, Lowenstein, Daniel H., Conwit, Robin A., Bleck, Thomas P., Cloyd, James C., Panagos, Peter

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Pharmacokinetics, Safety, and Tolerability of Orally Administered Ursodeoxycholic Acid in Patients With Parkinson's Disease—A Pilot Study by Sathe, Abhishek G., Tuite, Paul, Chen, Chi, Ma, Yiwei, Chen, Wei, Cloyd, James, Low, Walter C., Steer, Clifford J., Lee, Byeong‐Yeul, Zhu, Xiao‐Hong, Coles, Lisa D.

“…Mitochondrial dysfunction is implicated in the pathogenesis of Parkinson's disease. Preliminary data have shown lower brain adenosine triphosphate (ATP) levels…”
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Therapeutic Protein Drug Interaction Potential in Subjects With Psoriasis: An Assessment Based on Population Pharmacokinetic Analyses of Sensitive Cytochrome P450 Probe Substrates by Sathe, Abhishek G., Othman, Ahmed A., Mohamed, Mohamed‐Eslam F.

“…Elevated cytokine levels in inflammatory diseases are associated with downregulation of certain cytochrome P450 (CYP) enzymes. Upon treatment with some…”
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Early prediction of polymyxin-induced nephrotoxicity with next-generation urinary kidney injury biomarkers by Keirstead, Natalie D, Wagoner, Matthew P, Bentley, Patricia, Blais, Marie, Brown, Crystal, Cheatham, Letitia, Ciaccio, Paul, Dragan, Yvonne, Ferguson, Douglas, Fikes, Jim, Galvin, Melanie, Gupta, Anshul, Hale, Michael, Johnson, Nakpangi, Luo, Wenli, McGrath, Frank, Pietras, Mark, Price, Sally, Sathe, Abhishek G, Sasaki, Jennifer C, Snow, Debra, Walsky, Robert L, Kern, Gunther

“…Despite six decades of clinical experience with the polymyxin class of antibiotics, their dose-limiting nephrotoxicity remains difficult to predict due to a…”
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The association of patient weight and dose of fosphenytoin, levetiracetam, and valproic acid with treatment success in status epilepticus by Sathe, Abhishek G., Elm, Jordan J., Cloyd, James C., Chamberlain, James M., Silbergleit, Robert, Kapur, Jaideep, Cock, Hannah R., Fountain, Nathan B., Shinnar, Shlomo, Lowenstein, Daniel H., Conwit, Robin A., Bleck, Thomas P., Coles, Lisa D.

“…The Established Status Epilepticus Treatment Trial was a blinded, comparative‐effectiveness study of fosphenytoin, levetiracetam, and valproic acid in…”
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Early Exposure of Fosphenytoin, Levetiracetam, and Valproic Acid After High‐Dose Intravenous Administration in Young Children With Benzodiazepine‐Refractory Status Epilepticus by Sathe, Abhishek G., Mishra, Usha, Ivaturi, Vijay, Brundage, Richard C., Cloyd, James C., Elm, Jordan J., Chamberlain, James M., Silbergleit, Robert, Kapur, Jaideep, Lowenstein, Daniel H., Shinnar, Shlomo, Cock, Hannah R., Fountain, Nathan B., Babcock, Lynn, Coles, Lisa D.

“…Fosphenytoin (FOS) and its active form, phenytoin (PHT), levetiracetam (LEV), and valproic acid (VPA) are commonly used second‐line treatments of status…”
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Exposure-response analyses of sacituzumab govitecan (SG) efficacy and safety in patients (pts) with metastatic triple-negative breast cancer (mTNBC) by Singh, Indrajeet, Sathe, Abhishek G., Singh, Pratap, Diderichsen, Paul M., Fauchet, Floris, Maringwa, John, Pierrillas, Philippe, Phan, See-Chun, Girish, Sandhya, Othman, Ahmed A.

“…1076 Background: SG is an antibody-drug conjugate composed of an anti–Trop-2 antibody coupled to the cytotoxic SN-38 payload via a proprietary, hydrolyzable…”
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Quantitative Assessment of Occipital Metabolic and Energetic Changes in Parkinson's Patients, Using In Vivo 31 P MRS-Based Metabolic Imaging at 7T by Zhu, Xiao-Hong, Lee, Byeong-Yeul, Tuite, Paul, Coles, Lisa, Sathe, Abhishek G, Chen, Chi, Cloyd, Jim, Low, Walter C, Steer, Clifford J, Chen, Wei

“…Abnormal energy metabolism associated with mitochondrial dysfunction is thought to be a major contributor to the progression of neurodegenerative diseases such…”
Get full text