Search Results - "Sastry, G N"

Stability estimation through multivariate approach among solasodine-rich lines of Solanum khasianum (C.B. Clarke): an important industrial plant by Begum, Twahira, Munda, Sunita, Gupta, Tanmita, Gogoi, Roktim, Choubey, Vikash Kumar, Chanda, Sanjoy K, Lekhak, Himangshu, Sastry, G N, Lal, Mohan

“…is a medicinally important plant that is a source of steroidal alkaloids 'solasodine.' It has various industrial applications, including oral contraceptives…”
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Intra-urban differences in the prevalence of the metabolic syndrome in southern India - the Chennai Urban Population Study (CUPS No. 4) by Mohan, V., Shanthirani, S., Deepa, R., Premalatha, G., Sastry, N. G., Saroja, R.

“…SUMMARY Aims  To assess the influence of socioeconomic status on the prevalence of the metabolic syndrome in an urban south Indian population in Chennai…”
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Molecular modeling studies of phenoxypyrimidinyl imidazoles as p38 kinase inhibitors using QSAR and docking by Ravindra, G.K., Achaiah, G., Sastry, G.N.

“…p38 Kinase plays a vital role in inflammation mediated by tumor necrosis factor-α (TNFα) and interleukin-1β (IL-1β) pathways and inhibitors of p38 kinase…”
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Assessment of theoretical methods for the calculation of methyl cation affinities by Wei, Y, Singer, T, Mayr, H, Sastry, G.N, Zipse, H

“…The methyl cation affinity (MCA; 298 K) of a variety of neutral and anionic bases has been examined computationally with a wide variety of theoretical methods…”
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How good are publicly available web services that predict bioactivity profiles for drug repurposing? by Murtazalieva, K. A., Druzhilovskiy, D. S., Goel, R. K., Sastry, G. N., Poroikov, V. V.

“…Drug repurposing provides a non-laborious and less expensive way for finding new human medicines. Computational assessment of bioactivity profiles shed light…”
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Computational platform Way2Drug: from the prediction of biological activity to drug repurposing by Druzhilovskiy, D. S., Rudik, A. V., Filimonov, D. A., Gloriozova, T. A., Lagunin, A. A., Dmitriev, A. V., Pogodin, P. V., Dubovskaya, V. I., Ivanov, S. M., Tarasova, O. A., Bezhentsev, V. M., Murtazalieva, K. A., Semin, M. I., Maiorov, I. S., Gaur, A. S., Sastry, G. N., Poroikov, V. V.

“…The Way2Drug informational-computational platform (www.way2drug.com/dr) provides access to the data on drugs approved for medicinal use in the USA and Russian…”
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Prevalence of insulin resistance syndrome in a selected south Indian population--the Chennai urban population study-7 [CUPS-7] by Deepa, R, Shanthirani, C S, Premalatha, G, Sastry, N G, Mohan, V

“…Although earlier studies had shown socio-economic factors to be strongly associated with the insulin resistance syndrome (IRS) and its components, there is…”
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Lipoprotein(a) is an independent risk factor for coronary artery disease in NIDDM patients in South India by MOHAN, V, DEEPA, R, SAI PRASHANTH HARANATH, PREMALATHA, G, REMA, M, NADIMINTI GANAPATHI SASTRY, ENAS, E. A

“…Lipoprotein(a) is an independent risk factor for coronary artery disease in NIDDM patients in South India. V Mohan , R Deepa , S P Haranath , G Premalatha , M…”
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Web Resources for Discovery and Development of New Medicines by Bezhentsev, V. M., Druzhilovskii, D. S., Ivanov, S. M., Filimonov, D. A., Sastry, G. N., Poroikov, V. V.

“…Modern drug discovery is based on the analysis of information about disease mechanisms, molecular targets, and pharmacological substances, the action of which…”
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performance of computational techniques in locating the charge separated intermediates in organocatalytic transformations by Wei, Yin, Sateesh, Bandaru, Maryasin, Boris, Sastry, G.N, Zipse, Hendrik

“…The formation of zwitterionic adducts between neutral nucleophiles such as NMe₃ and PMe₃ with neutral electrophiles such as methyl vinyl ketone (MVK) has been…”
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Molecular property diagnostic suite (MPDS): Development of disease-specific open source web portals for drug discovery by Nagamani, S., Gaur, A. S., Tanneeru, K., Muneeswaran, G., Madugula, S. S., Consortium, MPDS, Druzhilovskiy, D., Poroikov, V. V., Sastry, G. N.

“…Molecular property diagnostic suite (MPDS) is a Galaxy-based open source drug discovery and development platform. MPDS web portals are designed for several…”
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Peripheral vascular disease in non-insulin-dependent diabetes mellitus in South India by Mohan, V., Premalatha, G., Sastry, N.G.

“…The prevalence of peripheral vascular disease (PVD) was assessed in terms of ankle/brachial index by doppler studies in a large cohort of non-insulin-dependent…”
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Choline kinase: an important target for cancer by Janardhan, S, Srivani, P, Sastry, G Narahari

“…Choline kinase (ChoK) is a cytosolic enzyme present in various tissues, which catalyzes the phosphorylation of choline to form phosphorylcholine (PCho) in the…”
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Autonomic dysfunction in non-insulin-dependent diabetes mellitus and fibrocalculous pancreatic diabetes in south India by Mohan, V, Sastry, N G, Premalatha, G

“…The prevalence of cardiovascular autonomic dysfunction in non-insulin-dependent (Type 2) diabetes mellitus (NIDDM) and fibrocalculous pancreatic diabetes…”
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Clinical experience with insulin detemir, biphasic insulin aspart and insulin aspart in people with type 2 diabetes: Results from the Hyderabad cohort of the A1chieve study by Santosh, R, Mehrotra, Ravi, Sastry, N G

“…The A1chieve, a multicentric (28 countries), 24-week, non-interventional study evaluated the safety and effectiveness of insulin detemir, biphasic insulin…”
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Differentiation of isomeric 2-aryldimethyltetrahydro-5-quinolinones by electron ionization and electrospray ionization mass spectrometry by Dinesh Kumar, Ch, Naresh Chary, V., Dinesh, A., Reddy, P. S., Srinivas, K., Gayatri, G., Sastry, G. N., Prabhakar, S.

“…A series of isomeric 2‐aryl‐6,6‐dimethyltetrahydro‐5‐quinolinones (set I) and 2‐aryl‐7,7‐dimethyltetrahydro‐5‐quinolinones (set II) were studied under positive…”
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Subtype selectivity in phosphodiesterase 4 (PDE4): a bottleneck in rational drug design by Srivani, P, Usharani, D, Jemmis, Eluvathingal D, Sastry, G Narahari

“…Subtype selectivity of phosphodiesterase 4 (PDE4) has been proposed to be the most salient feature for the development of drugs for asthma and inflammation…”
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Triply bridged (1,3,5) cyclophanes from cystine and lanthionine linkers—a comparison by Ranganathan, S., Venkateshwarlu, P., Babu, S.M., Reddy, N.S., Basha, S.J., Sarma, A.V.S., Vijay, D., Sastry, G.N.

“…The condensation of benzene 1,3,5-tricarbonylchloride with cystine-di-Me [H 2N–CH(COOMe)–CH 2–S–S–CH 2–CH(COOMe)–NH 2] yielded triply bridged (1,3,5)…”
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Clinical experience with insulin detemir, biphasic insulin aspart and insulin aspart in people with type 2 diabetes: Results from the Hyderabad cohort of the A 1 chieve study by Santosh, R, Mehrotra, Ravi, Sastry, NG

“…Background: The A 1 chieve, a multicentric (28 countries), 24-week, non-interventional study evaluated the safety and effectiveness of insulin detemir,…”
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Heterobuckybowls:  A Theoretical Study on the Structure, Bowl-to-Bowl Inversion Barrier, Bond Length Alternation, Structure-Inversion Barrier Relationship, Stability, and Synthetic Feasibility by Priyakumar, U. Deva, Sastry, G. Narahari

“…Hybrid density functional theory (DFT) calculations at the B3LYP/cc-pVDZ level have been performed on a series of heterobuckybowls, 3X, C18X3H6 (X = O, NH,…”
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