Search Results - "Sastri, Jaya"
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Dynamics and regulation of nuclear import and nuclear movements of HIV-1 complexes
Published in PLoS pathogens (21-08-2017)“…The dynamics and regulation of HIV-1 nuclear import and its intranuclear movements after import have not been studied. To elucidate these essential HIV-1…”
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TRIM5α associates with proteasomal subunits in cells while in complex with HIV-1 virions
Published in Retrovirology (12-11-2011)“…The TRIM5 proteins are cellular restriction factors that prevent retroviral infection in a species-specific manner. Multiple experiments indicate that…”
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TRIM5α-Mediated Ubiquitin Chain Conjugation Is Required for Inhibition of HIV-1 Reverse Transcription and Capsid Destabilization
Published in Journal of virology (15-02-2016)“…Rhesus macaque TRIM5α (rhTRIM5α) is a retroviral restriction factor that inhibits HIV-1 infection. Previous studies have revealed that TRIM5α restriction…”
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Recent insights into the mechanism and consequences of TRIM5α retroviral restriction
Published in AIDS research and human retroviruses (01-03-2011)“…The cellular factor TRIM5α inhibits infection by numerous retroviruses in a species-specific manner. The TRIM5α protein from rhesus macaques (rhTRIM5α)…”
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Dynamic conformational changes in the rhesus TRIM5α dimer dictate the potency of HIV-1 restriction
Published in Virology (New York, N.Y.) (01-01-2017)“…Abstract The TRIM5α protein from rhesus macaques (rhTRIM5α) mediates a potent inhibition of HIV-1 infection via a mechanism that involves the abortive…”
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Restriction of HIV-1 by rhesus TRIM5α is governed by alpha helices in the Linker2 region
Published in Journal of virology (01-08-2014)“…TRIM5α proteins are a potent barrier to the cross-species transmission of retroviruses. TRIM5α proteins exhibit an ability to self-associate at many levels,…”
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Identification of residues within the L2 region of rhesus TRIM5α that are required for retroviral restriction and cytoplasmic body localization
Published in Virology (New York, N.Y.) (15-09-2010)“…Abstract The intracellular restriction factor TRIM5α, inhibits infection by numerous retroviruses in a species-specific manner. The best characterized example…”
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Identification of residues within the L2 region of rhesus TRIM5a that are required for retroviral restriction and cytoplasmic body localization
Published in Virology (New York, N.Y.) (15-09-2010)“…The intracellular restriction factor TRIM5a, inhibits infection by numerous retroviruses in a species-specific manner. The best characterized example of this…”
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Proceedings of the Frontiers of Retrovirology Conference 2016
Published in Retrovirology (26-09-2016)“…Oral presentations Session 1: Entry & uncoating O1 Host cell polo-like kinases (PLKs) promote early prototype foamy virus (PFV) replication Irena Zurnic,…”
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TRIM5[alpha] associates with proteasomal subunits in cells while in complex with HIV-1 virions
Published in Retrovirology (12-11-2011)“…Background The TRIM5 proteins are cellular restriction factors that prevent retroviral infection in a species-specific manner. Multiple experiments indicate…”
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Journal Article -
11
Identification of residues within the L2 region of rhesus TRIM5alpha that are required for retroviral restriction and cytoplasmic body localization
Published in Virology (New York, N.Y.) (15-09-2010)“…The intracellular restriction factor TRIM5alpha, inhibits infection by numerous retroviruses in a species-specific manner. The best characterized example of…”
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