Search Results - "Sastre Torano, Javier"

Nanobody-Targeted Photodynamic Therapy Selectively Kills Viral GPCR-Expressing Glioblastoma Cells by De Groof, Timo W. M, Mashayekhi, Vida, Fan, Tian Shu, Bergkamp, Nick D, Sastre Toraño, Javier, van Senten, Jeffrey R, Heukers, Raimond, Smit, Martine J, Oliveira, Sabrina

“…Photodynamic therapy (PDT) eradicates tumors by the local activation of a photosensitizer with near-infrared light. One of the aspects hampering the clinical…”
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Protecting‐Group‐Controlled Enzymatic Glycosylation of Oligo‐N‐Acetyllactosamine Derivatives by Gagarinov, Ivan A., Li, Tiehai, Wei, Na, Sastre Toraño, Javier, de Vries, Robert P., Wolfert, Margreet A., Boons, Geert‐Jan

“…We describe a chemoenzymatic strategy that can give a library of differentially fucosylated and sialylated oligosaccharides starting from a single chemically…”
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Oxidative Release of O‑Glycans under Neutral Conditions for Analysis of Glycoconjugates Having Base-Sensitive Substituents by Vos, Gaël M., Weber, Julia, Sweet, Igor R., Hooijschuur, Kevin C., Sastre Toraño, Javier, Boons, Geert-Jan

“…Protein O-glycosylation is one of the most diverse post-translational modifications. A critical step in the analysis of O-glycomes is the release of glycans…”
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Quantitative Translation of Microfluidic Transporter in Vitro Data to in Vivo Reveals Impaired Albumin-Facilitated Indoxyl Sulfate Secretion in Chronic Kidney Disease by van der Made, Thomas K, Fedecostante, Michele, Scotcher, Daniel, Rostami-Hodjegan, Amin, Sastre Toraño, Javier, Middel, Igor, Koster, Andries S, Gerritsen, Karin G, Jankowski, Vera, Jankowski, Joachim, Hoenderop, Joost G. J, Masereeuw, Rosalinde, Galetin, Aleksandra

“…Indoxyl sulfate (IxS), a highly albumin-bound uremic solute, accumulates in chronic kidney disease (CKD) due to reduced renal clearance. This study was…”
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A High‐Resolution Crystal Structure that Reveals Molecular Details of Target Recognition by the Calcium‐Dependent Lipopeptide Antibiotic Laspartomycin C by Kleijn, Laurens H. J., Vlieg, Hedwich C., Wood, Thomas M., Sastre Toraño, Javier, Janssen, Bert J. C., Martin, Nathaniel I.

“…The calcium‐dependent antibiotics (CDAs) are an important emerging class of antibiotics. The crystal structure of the CDA laspartomycin C in complex with…”
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Chemoenzymatic Approach for the Preparation of Asymmetric Bi‑, Tri‑, and Tetra-Antennary N‑Glycans from a Common Precursor by Gagarinov, Ivan A, Li, Tiehai, Toraño, Javier Sastre, Caval, Tomislav, Srivastava, Apoorva D, Kruijtzer, John A. W, Heck, Albert J. R, Boons, Geert-Jan

“…Progress in glycoscience is hampered by a lack of well-defined complex oligosaccharide standards that are needed to fabricate the next generation of…”
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Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion by Jansen, Jitske, Jansen, Katja, Neven, Ellen, Poesen, Ruben, Othman, Amr, van Mil, Alain, Sluijter, Joost, Torano, Javier Sastre, Zaal, Esther A., Berkers, Celia R., Esser, Diederik, Wichers, Harry J., van Ede, Karin, van Duursen, Majorie, Burtey, Stéphane, Verhaar, Marianne C., Meijers, Björn, Masereeuw, Rosalinde

“…Membrane transporters and receptors are responsible for balancing nutrient and metabolite levels to aid body homeostasis. Here, we report that proximal tubule…”
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Identification of Isomeric N‐Glycans by Conformer Distribution Fingerprinting using Ion Mobility Mass Spectrometry by Sastre Toraño, Javier, Aizpurua‐Olaizola, Oier, Wei, Na, Li, Tiehai, Unione, Luca, Jiménez‐Osés, Gonzalo, Corzana, Francisco, Somovilla, Victor J., Falcon‐Perez, Juan M., Boons, Geert‐Jan

“…Glycans possess unparalleled structural complexity arising from chemically similar monosaccharide building blocks, configurations of anomeric linkages and…”
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EGFR-Targeted Nanobody Functionalized Polymeric Micelles Loaded with mTHPC for Selective Photodynamic Therapy by Liu, Yanna, Scrivano, Luca, Peterson, Julia Denise, Fens, Marcel H. A. M, Hernández, Irati Beltrán, Mesquita, Bárbara, Toraño, Javier Sastre, Hennink, Wim E, van Nostrum, Cornelus F, Oliveira, Sabrina

“…meta-Tetra­(hydroxyphenyl)­chlorin (mTHPC) is one of the most potent second-generation photosensitizers, clinically used for photodynamic therapy (PDT) of head…”
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Ion‐Mobility Spectrometry Can Assign Exact Fucosyl Positions in Glycans and Prevent Misinterpretation of Mass‐Spectrometry Data After Gas‐Phase Rearrangement by Sastre Toraño, Javier, Gagarinov, Ivan A., Vos, Gaël M., Broszeit, Frederik, Srivastava, Apoorva D., Palmer, Martin, Langridge, James I., Aizpurua‐Olaizola, Oier, Somovilla, Victor J., Boons, Geert‐Jan

“…The fucosylation of glycans leads to diverse structures and is associated with many biological and disease processes. The exact determination of fucoside…”
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Sialic acid O-acetylation patterns and glycosidic linkage type determination by ion mobility-mass spectrometry by Vos, Gaёl M., Hooijschuur, Kevin C., Li, Zeshi, Fjeldsted, John, Klein, Christian, de Vries, Robert P., Toraño, Javier Sastre, Boons, Geert-Jan

“…O -acetylation is a common modification of sialic acids that has been implicated in a multitude of biological and disease processes. A lack of analytical…”
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Methyleneation of Peptides by N,N,N,N‑Tetramethylethylenediamine (TEMED) under Conditions Used for Free Radical Polymerization: A Mechanistic Study by Shirangi, Mehrnoosh, Sastre Toraño, Javier, Sellergren, Börje, Hennink, Wim E, Somsen, Govert W, van Nostrum, Cornelus F

“…Free radical polymerization is often used to prepare protein and peptide-loaded hydrogels for the design of controlled release systems and molecular imprinting…”
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Limited Lactosylation of Beta-Lactoglobulin from Cow’s Milk Exerts Strong Influence on Antigenicity and Degranulation of Mast Cells by Bosman, Gerlof P, Oliveira, Sergio, Simons, Peter J, Sastre Torano, Javier, Somsen, Govert W, Knippels, Leon M. J, Haselberg, Rob, Pieters, Roland J, Garssen, Johan, Knipping, Karen

“…Background: beta-lactoglobulin (BLG) is one of the major cow’s milk proteins and the most abundant allergen in whey. Heating is a common technologic treatment…”
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Bicyclic isoureas derived from 1-deoxynojirimycin are potent inhibitors of β-glucocerebrosidase by Sevšek, Alen, Čelan, Maša, Erjavec, Bibi, Quarles van Ufford, Linda, Sastre Toraño, Javier, Moret, Ed E, Pieters, Roland J, Martin, Nathaniel I

“…A series of bicyclic isourea derivatives were prepared from 1-deoxynojirimycin using a concise synthetic protocol proceeding via a guanidino intermediate…”
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Evaluation of fritless solid-phase extraction coupled on-line with capillary electrophoresis-mass spectrometry for the analysis of opioid peptides in cerebrospinal fluid by Medina-Casanellas, Silvia, Tak, Yvonne H., Benavente, Fernando, Sanz-Nebot, Victoria, Toraño, Javier Sastre, Somsen, Govert W., de Jong, Gerhardus J.

“…Fritless SPE on‐line coupled to CE with UV and MS detection (SPE‐CE‐UV and SPE‐CE‐MS) was evaluated for the analysis of opioid peptides. A microcartridge of…”
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Biomarkers of the alcohol hangover state: Ethyl glucuronide (EtG) and ethyl sulfate (EtS) by Mackus, Marlou, Loo, Aurora J. A. E., Raasveld, S. Jorinde, Hogewoning, Anna, Sastre Toraño, Javier, Flesch, Frits M., Korte‐Bouws, Gerdien A. H., Neer, Renier H. P., Wang, Xiaochun, Nguyen, Thomas T., Brookhuis, Karel A., Kraneveld, Aletta D., Garssen, Johan, Verster, Joris C.

“…Introduction The aim of this study was to investigate the usefulness of ethyl glucuronide (EtG) and ethyl sulfate (EtS) as biomarkers of the hangover state…”
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Determination of oversulfated chondroitin sulfate and dermatan sulfate impurities in heparin by capillary electrophoresis by Somsen, Govert W., Tak, Yvonne H., Toraño, Javier Sastre, Jongen, Peter M.J.M., de Jong, Gerhardus J.

“…Recently, oversulfated chondroitin sulfate (OSCS) present in certain lots of heparin was identified as the toxic contaminant responsible for severe side…”
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Analysis of recombinant human growth hormone by capillary electrophoresis with bilayer-coated capillaries using UV and MS detection by Catai, Jonatan R., Sastre Toraño, Javier, Jongen, Peter M.J.M., de Jong, Gerhardus J., Somsen, Govert W.

“…The characterization of recombinant human growth hormone (rhGH; somatropin) by capillary electrophoresis (CE) with UV-absorbance and mass spectrometric (MS)…”
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Orthoester functionalized N -guanidino derivatives of 1,5-dideoxy-1,5-imino-d-xylitol as pH-responsive inhibitors of β-glucocerebrosidase by Sevšek, Alen, Sastre Toraño, Javier, Quarles van Ufford, Linda, Moret, Ed E, Pieters, Roland J, Martin, Nathaniel I

“…Alkylated guanidino derivatives of 1,5-dideoxy-1,5-imino-d-xylitol bearing an orthoester moiety were prepared using a concise synthetic protocol. Inhibition…”
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Determination of trehalose-6-phosphate in Arabidopsis thaliana seedlings by hydrophilic-interaction liquid chromatography–mass spectrometry by Sastre Toraño, Javier, Delatte, Thierry L., Schluepmann, Henriette, Smeekens, Sjef C. M., de Jong, Gerhardus J., Somsen, Govert W.

“…A hydrophilic-interaction chromatography (HILIC) method coupled to electrospray ionization mass spectrometry (ESI-MS) was developed for the determination of…”
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