Search Results - "Sasmal, Pradip K."

Anti-angiogenic and antioxidant effects of axitinib in human retinal endothelial cells: implications in diabetic retinopathy by Lazzara, Francesca, Conti, Federica, Sasmal, Pradip K, Alikunju, Shanavas, Rossi, Settimio, Drago, Filippo, Platania, Chiara Bianca Maria, Bucolo, Claudio

“…Diabetic retinopathy is a secondary microvascular complication of diabetes mellitus. This disease progresses from two stages, non-proliferative and…”
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Melanin concentrating hormone receptor 1 (MCHR1) antagonists—Still a viable approach for obesity treatment? by Högberg, Thomas, Frimurer, Thomas M., Sasmal, Pradip K.

“…Obesity is a global epidemic associated with multiple severe diseases. Several pharmacotherapies have been investigated including the melanin concentrating…”
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Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists by Sasmal, Sanjita, Balaji, Gade, Kanna Reddy, Hariprasada R., Balasubrahmanyam, D., Srinivas, Gujjary, Kyasa, Shiva K., Sasmal, Pradip K., Khanna, Ish, Talwar, Rashmi, Suresh, J., Jadhav, Vikram P., Muzeeb, Syed, Shashikumar, Dhanya, Harinder Reddy, K., Sebastian, V.J., Frimurer, Thomas M., Rist, Øystein, Elster, Lisbeth, Högberg, Thomas

“…The receptor model-supported design, synthesis and multi-parameter optimization of novel quinazoline derivatives as MCHR1 antagonists are described. The in…”
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Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists: Part 2 by Sasmal, Sanjita, Balasubrahmanyam, D., Kanna Reddy, Hariprasada R., Balaji, Gade, Srinivas, Gujjary, Cheera, Srisailam, Abbineni, Chandrasekhar, Sasmal, Pradip K., Khanna, Ish, Sebastian, V.J., Jadhav, Vikram P., Singh, Manvendra P., Talwar, Rashmi, Suresh, J., Shashikumar, Dhanya, Harinder Reddy, K., Sihorkar, V., Frimurer, Thomas M., Rist, Øystein, Elster, Lisbeth, Högberg, Thomas

“…The synthesis and design guided by SAR and SPR studies of novel quinazoline derivatives as MCHR1 antagonists are described. Compound 8 (DRL-21816) has emerged…”
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A deep eutectic-based, self-emulsifying subcutaneous depot system for apomorphine therapy in Parkinson's disease by Kim, Jayoung, Gao, Yongsheng, Zhao, Zongmin, Rodrigues, Danika, Tanner, Eden E L, Ibsen, Kelly, Sasmal, Pradip K, Jaladi, Rajasekhar, Alikunju, Shanavas, Mitragotri, Samir

“…Apomorphine, a dopamine agonist, is a highly effective therapeutic to prevent intermittent off episodes in advanced Parkinson's disease. However, its short…”
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Asymmetric Synthesis of Hexapropionate Synthons by Sequential Enantiotopic Group Selective Enolization of Meso Diketones by Ward, Dale E, Gillis, H. Martin, Akinnusi, Olukayode T, Rasheed, M. Abdul, Saravanan, K, Sasmal, Pradip K

“…Meso 1,9-diketones (six to seven stereocenters) are readily obtained by stepwise or simultaneous two-directional aldol reactions of…”
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Studies toward the Synthesis of Azadirachtin, Part 2: Construction of Fully Functionalized ABCD Ring Frameworks and Unusual Intramolecular Reactions Induced by Close-Proximity Effects by Nicolaou, K. C., Sasmal, Pradip K., Koftis, Theocharis V., Converso, Antonella, Loizidou, Eriketi, Kaiser, Florian, Roecker, A. J., Dellios, Constantinos C., Sun, Xiao-Wen, Petrovic, Goran

“…The remarkable antifeedant agent and insecticide, azadirachtin (1), has, to date, escaped a total synthesis. The preparation of an advanced precursor has…”
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Total Synthesis of 1-O-Methyllateriflorone by Nicolaou, K. C., Sasmal, Pradip K., Xu, Hao, Namoto, Kenji, Ritzén, Andreas

“…The unique spiroxalactone framework of lateriflorone (1) consists of a prenylated dihydrobenzoquinone moiety and a trioxatetracyclotetradecane system. A tandem…”
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Formation of Bicyclic Ethers from Lewis Acid Promoted Cyclizations of Cyclic Oxonium Ions by Sasmal, Pradip K, Maier, Martin E

“…Oxacycles carrying a vinyl group and an acetal were extended with a cyclization terminator (vinyl silane or vinyl sulfide) by Suzuki coupling. Treatment with…”
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First total synthesis of 3a-hydroxy-1,1-dimethyl-5-((N-methylsulfamoyl)methyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-1-ium 2,2,2-trifluoroacetate by mimicking the oxidative degradation pathway of sumatriptan by Sasmal, Pradip K., Ramachandran, Ganesh, Zhang, Ying, Liu, Zhong

“…[Display omitted] •Forced degradation studies were performed on sumatriptan autoinjector product Zembrace under different stress conditions.•The primary…”
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Thiopyran Route to Polypropionates:  Aldol Diastereoselectivity of Linear and Two-Directional Iterative Homologations by Ward, Dale E, Guo, Cheng, Sasmal, Pradip K, Man, Chuk C, Sales, Marcelo

“…Aldol reaction of tetrahydro-4H-thiopyran-4-one with racemic 1,4-dioxa-8-thiaspiro[4.5]decane-6-carboxaldehyde is easily controlled to give the…”
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Novel pyrazole-3-carboxamide derivatives as cannabinoid-1 (CB1) antagonists: Journey from non-polar to polar amides by Sasmal, Pradip K., Reddy, D. Srinivasa, Talwar, Rashmi, Venkatesham, B., Balasubrahmanyam, D., Kannan, M., Srinivas, P., Kyasa, Shiva K., Devi, B. Neelima, Jadhav, Vikram P., Khan, Sanjoy K., Mohan, Priya, Chaudhury, Hira, Bhuniya, Debnath, Iqbal, Javed, Chakrabarti, Ranjan

“…The synthesis and biological evaluation of novel pyrazole-3-carboxamide derivatives as CB1 antagonists are described. The in vivo proof of principle for weight…”
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Optimisation of in silico derived 2-aminobenzimidazole hits as unprecedented selective kappa opioid receptor agonists by Sasmal, Pradip K., Krishna, C. Vamsee, Adabala, S. Sudheerkumar, Roshaiah, M., Rawoof, Khaji Abdul, Thadi, Emima, Sukumar, K. Pavan, Cheera, Srisailam, Abbineni, Chandrasekhar, Rao, K.V.L. Narasimha, Prasanthi, A., Nijhawan, Kamal, Jaleel, Mahaboobi, Iyer, Lakshmi Ramachandran, Chaitanya, T. Krishna, Tiwari, Nirbhay Kumar, Krishna, N. Lavanya, Potluri, Vijay, Khanna, Ish, Frimurer, Thomas M., Lückmann, Michael, Rist, Øystein, Elster, Lisbeth, Högberg, Thomas

“…[Display omitted] Kappa opioid receptor (KOR) is an important mediator of pain signaling and it is targeted for the treatment of various pains. Pharmacophore…”
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Biomimetically Inspired Total Synthesis and Structure Activity Relationships of 1-O-Methyllateriflorone. 6π Electrocyclizations in Organic Synthesis by Nicolaou, K. C, Sasmal, Pradip K, Xu, Hao

“…The total synthesis of 1-O-methyllateriflorone (2) is described. The construction of the cage-like domain of the molecule involved a biomimetic…”
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Structure–activity relationship studies of novel pyrazole and imidazole carboxamides as cannabinoid-1 (CB1) antagonists by Sasmal, Pradip K., Talwar, Rashmi, Swetha, J., Balasubrahmanyam, D., Venkatesham, B., Rawoof, Khaji Abdul, Neelima Devi, B., Jadhav, Vikram P., Khan, Sanjoy K., Mohan, Priya, Srinivasa Reddy, D., Nyavanandi, Vijay Kumar, Nanduri, Srinivas, Kyasa, Shiva K., Kannan, M., Srinivas, P., Nadipalli, Prabhakar, Chaudhury, Hira, Sebastian, V.J.

“…The synthesis and biological evaluation of novel pyrazole and imidazole carboxamides as CB1 antagonists are described. The in vivo proof of principle for…”
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Design, Synthesis, and Biological Properties of Highly Potent Epothilone B Analogues by Nicolaou, K. C., Sasmal, Pradip K., Rassias, Gerasimos, Reddy, Mali Venkat, Altmann, Karl-Heinz, Wartmann, Markus, O'Brate, Aurora, Giannakakou, Paraskevi

“…A number of rationally designed epoxide and cyclopropane epothilone B (1) analogues with substituted side chains were prepared and their biological activities…”
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Discovery of novel, orally available benzimidazoles as melanin concentrating hormone receptor 1 (MCHR1) antagonists by Sasmal, Pradip K., Sasmal, Sanjita, Rao, P. Tirumala, Venkatesham, B., Roshaiah, M., Abbineni, Chandrasekhar, Khanna, Ish, Jadhav, Vikram P., Suresh, J., Talwar, Rashmi, Muzeeb, Syed, Receveur, Jean-Marie, Frimurer, Thomas M., Rist, Øystein, Elster, Lisbeth, Högberg, Thomas

“…The synthesis and biological evaluation of novel benzimidazole derivatives as MCHR1 antagonists are described. The in vivo proof of principle for weight loss…”
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Studies toward the Synthesis of Azadirachtin, Part 1: Total Synthesis of a Fully Functionalized ABC Ring Framework and Coupling with a Norbornene Domain by Nicolaou, K. C., Sasmal, Pradip K., Roecker, A. J., Sun, Xiao-Wen, Mandal, Sunil, Converso, Antonella

“…The advanced decalin intermediate 1 was synthesized and elaborated into the potential azadirachtin precursor 2. The challenging synthesis involved several…”
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Syn−Anti Isomerization of Aldols by Enolization by Ward, Dale E, Sales, Marcelo, Sasmal, Pradip K

“…A variety of aldol adducts are shown to undergo efficient syn−anti isomerization in the presence of imidazole by an enolization mechanism. Isomerizations are…”
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Acetal−Vinyl Sulfide Cyclization on Sugar Substrates:  Effect of Structure and Substituent by Sasmal, Pradip K, Maier, Martin E

“…A range of 2-deoxyfuranoside and -pyranoside derivatives were fashioned into derivatives that carry a vinyl or propenyl side chain. Extension of the alkene by…”
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