Search Results - "Saslowsky, David E."

Mechanism for adhesion G protein-coupled receptor GPR56-mediated RhoA activation induced by collagen III stimulation by Luo, Rong, Jeong, Sung-Jin, Yang, Annie, Wen, Miaoyun, Saslowsky, David E, Lencer, Wayne I, Araç, Demet, Piao, Xianhua

“…GPR56 is a member of the adhesion G protein-coupled receptor (GPCR) family. Despite the importance of GPR56 in brain development, where mutations cause a…”
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Lipid Sorting by Ceramide Structure from Plasma Membrane to ER for the Cholera Toxin Receptor Ganglioside GM1 by Chinnapen, Daniel J.-F., Hsieh, Wan-Ting, te Welscher, Yvonne M., Saslowsky, David E., Kaoutzani, Lydia, Brandsma, Eelke, D'Auria, Ludovic, Park, Hyejung, Wagner, Jessica S., Drake, Kimberly R., Kang, Minchul, Benjamin, Thomas, Ullman, M. David, Costello, Catherine E., Kenworthy, Anne K., Baumgart, Tobias, Massol, Ramiro H., Lencer, Wayne I.

“…The glycosphingolipid GM1 binds cholera toxin (CT) on host cells and carries it retrograde from the plasma membrane (PM) through endosomes, the trans-Golgi…”
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Ganglioside GM1-mediated Transcytosis of Cholera Toxin Bypasses the Retrograde Pathway and Depends on the Structure of the Ceramide Domain by Saslowsky, David E., te Welscher, Yvonne M., Chinnapen, Daniel J.-F., Wagner, Jessica S., Wan, Joy, Kern, Eli, Lencer, Wayne I.

“…Cholera toxin causes diarrheal disease by binding ganglioside GM1 on the apical membrane of polarized intestinal epithelial cells and trafficking retrograde…”
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Nuclear Localization of Flavonoid Enzymes in Arabidopsis by Saslowsky, David E., Warek, Ujwala, Winkel, Brenda S.J.

“…Flavonoids represent one of the oldest, largest, and most diverse families of plant secondary metabolites. These compounds serve a wide range of functions in…”
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Real-Time Analysis of the Effects of Cholesterol on Lipid Raft Behavior Using Atomic Force Microscopy by Lawrence, Jared C., Saslowsky, David E., Michael Edwardson, J., Henderson, Robert M.

“…Cholesterol plays a crucial role in cell membranes, and has been implicated in the assembly and maintenance of sphingolipid-rich rafts. We have examined the…”
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Attenuated Endocytosis and Toxicity of a Mutant Cholera Toxin with Decreased Ability To Cluster Ganglioside GM₁ Molecules by Wolf, Anne A, Jobling, Michael G, Saslowsky, David E, Kern, Eli, Drake, Kimberly R, Kenworthy, Anne K, Holmes, Randall K, Lencer, Wayne I

“…Cholera toxin (CT) moves from the plasma membrane (PM) of host cells to the endoplasmic reticulum (ER) by binding to the lipid raft ganglioside GM₁. The…”
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Placental Alkaline Phosphatase Is Efficiently Targeted to Rafts in Supported Lipid Bilayers by Saslowsky, David E., Lawrence, Jared, Ren, Xiaoyan, Brown, Deborah A., Henderson, Robert M., Edwardson, J. Michael

“…Evidence is growing that biological membranes contain lipid microdomains or “rafts” that may be involved in processes such as cellular signaling and protein…”
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Lipid Rafts: Feeling is Believing by Henderson, Robert M, Edwardson, J. Michael, Geisse, Nicholas A, Saslowsky, David E

“…Robert M. Henderson , J. Michael Edwardson , Nicholas A. Geisse and David E. Saslowsky Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD,…”
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Intoxication of zebrafish and mammalian cells by cholera toxin depends on the flotillin/reggie proteins but not Derlin-1 or -2 by Saslowsky, David E, Cho, Jin Ah, Chinnapen, Himani, Massol, Ramiro H, Chinnapen, Daniel J-F, Wagner, Jessica S, De Luca, Heidi E, Kam, Wendy, Paw, Barry H, Lencer, Wayne I

“…Cholera toxin (CT) causes the massive secretory diarrhea associated with epidemic cholera. To induce disease, CT enters the cytosol of host cells by co-opting…”
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Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion by Saslowsky, David E, Thiagarajah, Jay R, McCormick, Beth A, Lee, Jean C, Lencer, Wayne I

“…The apical brush border membrane (BBM) of intestinal epithelial cells forms a highly structured and dynamic environmental interface that serves to regulate…”
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Conversion of apical plasma membrane sphingomyelin to ceramide attenuates the intoxication of host cells by cholera toxin by Saslowsky, David E, Lencer, Wayne I

“…Cholera toxin (CT) enters host cells by binding to ganglioside GM1 in the apical plasma membrane (PM). GM1 carries CT retrograde from the PM to the endoplasmic…”
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642 The Lipid Raft Proteins Flotillin-½ Regulate Retrograde Traffic of Cholera Toxin Between Endosome and ER by Saslowsky, David E, Massol, Ramiro, Lencer, Wayne I

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Ceramide activates JNK to inhibit a cAMP-gated K⁺ conductance and Cl⁻ secretion in intestinal epithelia by Saslowsky, David E, Tanaka, Noriyuki, Reddy, Krishna P, Lencer, Wayne I

“…Sphingomyelinases (SMases) hydrolyze membrane sphingomyelin to ceramide and are expressed by diverse host and microbial cell types populating mucosal surfaces…”
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552 Intoxication of Zebrafish By Cholera Toxin Involves Flotillin But Not Derlin-1 by Saslowsky, David E, Chinnapen, Himani, Wagner, Jessica, Chinnapen, Daniel, Lencer, Wayne I

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Expression of chalcone synthase and chalcone isomerase proteins in Arabidopsis seedlings by Cain, C C, Saslowsky, D E, Walker, R A, Shirley, B W

“…Antibodies have been developed against the first two enzymes of flavonoid biosynthesis in Arabidopsis thaliana. Chalcone synthase (CHS) and chalcone isomerase…”
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Transcytosis of cholera toxin across polarized epithelia bypasses the Golgi and is dependent on GM1 acyl chain structure by Saslowsky, David E., Wagner, Jessica, Lencer, Wayne I.

“…Abstract only Cholera toxin (CT) is an AB5‐subunit toxin that enters host cells by binding ganglioside GM1. GM1 carries the toxin retrograde from the apical…”
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Attenuated Endocytosis and Toxicity of a Mutant Cholera Toxin with Decreased Ability To Cluster Ganglioside GM 1 Molecules by Wolf, Anne A., Jobling, Michael G., Saslowsky, David E., Kern, Eli, Drake, Kimberly R., Kenworthy, Anne K., Holmes, Randall K., Lencer, Wayne I.

“…Cholera toxin (CT) moves from the plasma membrane (PM) of host cells to the endoplasmic reticulum (ER) by binding to the lipid raft ganglioside GM 1 . The…”
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Attenuated Endocytosis and Toxicity of a Mutant Cholera Toxin with Decreased Ability To Cluster Ganglioside GM sub(1) Molecules by Wolf, Anne A, Jobling, Michael G, Saslowsky, David E, Kern, Eli, Drake, Kimberly R, Kenworthy, Anne K, Holmes, Randall K, Lencer, Wayne I

“…Cholera toxin (CT) moves from the plasma membrane (PM) of host cells to the endoplasmic reticulum (ER) by binding to the lipid raft ganglioside GM sub(1). The…”
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An allelic series for the chalcone synthase locus in Arabidopsis by Saslowsky, David E., Dana, Christopher D., Winkel-Shirley, Brenda

“…Five new alleles of the Arabidopsis chalcone synthase (CHS) locus, tt4, have been characterized at the gene, protein, and end product levels as a genetic…”
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