Search Results - "Sasikumar, G."

Small-Molecule Immune Checkpoint Inhibitors Targeting PD-1/PD-L1 and Other Emerging Checkpoint Pathways by Sasikumar, Pottayil G., Ramachandra, Murali

“…Advances in harnessing the immune system for cancer treatment have been spectacular in recent years as witnessed by the approval of a number of antibodies…”
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Small Molecule Agents Targeting PD-1 Checkpoint Pathway for Cancer Immunotherapy: Mechanisms of Action and Other Considerations for Their Advanced Development by Sasikumar, Pottayil G, Ramachandra, Murali

“…Pioneering success of antibodies targeting immune checkpoints such as programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4…”
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A Rationally Designed Peptide Antagonist of the PD-1 Signaling Pathway as an Immunomodulatory Agent for Cancer Therapy by Sasikumar, Pottayil G, Ramachandra, Raghuveer K, Adurthi, Srinivas, Dhudashiya, Amit A, Vadlamani, Sureshkumar, Vemula, Koteswararao, Vunnum, Sriharibabu, Satyam, Leena K, Samiulla, Dodderi S, Subbarao, Krishnaprasad, Nair, Rashmi, Shrimali, Rajeev, Gowda, Nagaraj, Ramachandra, Murali

“…Pioneering success of antibodies targeting immune checkpoints such as PD-1 and CTLA4 has opened novel avenues for cancer immunotherapy. Along with impressive…”
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Selective hydrogenation of levulinic acid over a highly dispersed and stable copper particles embedded into the ordered mesoporous carbon supported catalyst by Balla, Putrakumar, Seelam, Prem Kumar, Rajesh, Rajendiran, Balaga, Ravi, Challa, Prathap, G., Kauslya Sasikumar, Perupogu, Vijayanand, Lassi, Ulla, Sungtak, Kim

“…Transformation of levulinic acid (LA) to γ -valerolactone (GVL) via hydrogenation is a greener approach in synthesising the eco-friendly GVL fuel additive. In…”
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Catalytic response and molecular simulation studies in the development of synthetic routes in trimeric triaryl pyridinium type ionic liquids by Tamilarasan, Ramalingam, Subramani, Annadurai, Sasikumar, G., Ganapathi, Pandurangan, Karthikeyan, S., Ponnusamy, Sasikumar, Albukhaty, Salim, Mohammed, Mustafa K. A., Al-aqbi, Zaidon T., Al-Doghachi, Faris A. J., Ahmed, Duha S., Taufiq-Yap, Yun Hin

“…Under conventional and silica-supported Muffle furnace methods, water-soluble substituted trimeric triaryl pyridinium cations with various inorganic counter…”
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Dependence of optimum Nafion content in catalyst layer on platinum loading by Sasikumar, G, Ihm, J.W, Ryu, H

“…In polymer electrolyte membrane fuel cells (PEMFC), Nafion is used not only as a membrane placed between the anode and the cathode, but also as an important…”
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Experimental Analysis on Effective Electro Magnetic Braking System by Srinivasagupta, G., Sasikumar, G., Padmavathi S, Venkata, Rao Lokavarapu, Bhaskara

“…A traditional breaking system involves conversion of mechanical energy in to the heat energy leads to reduction in effectiveness of breaking due to thermal…”
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Molecular evidence for co-occurring cryptic lineages within the Sepioteuthis cf. lessoniana species complex in the Indian and Indo-West Pacific Oceans by Cheng, S. H., Anderson, F. E., Bergman, A., Mahardika, G. N., Muchlisin, Z. A., Dang, B. T., Calumpong, H. P., Mohamed, K. S., Sasikumar, G., Venkatesan, V., Barber, P. H.

“…The big-fin reef squid, Sepioteuthis cf. lessoniana (Lesson 1930), is an important commodity species within artisanal and near-shore fisheries in the Indian…”
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Optimum Nafion content in PEM fuel cell electrodes by Sasikumar, G., Ihm, J.W., Ryu, H.

“…Nafion ionomer is impregnated or incorporated in the PEM fuel cell electrodes to achieve high power density. Though many studies have been reported on the…”
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Design, synthesis and characterization of novel functional polyesters containing chromone curcumin units and evaluation of its anticancer potential-An in vitro and in silico approach by Subramani, A., Sasikumar, G., Sriram Prasath, G., Shabeer, T.K., Tamizhdurai, P., Yadav, Krishna Kumar, Albakri, Ghadah Shukri, Abbas, Mohamed, Awjan Alreshidi, Maha

“…A series of six novel polyesters (P1-P6) were obtained via by direct polycondenzation with hydroxyl functional-appended chromone and curcumin based monomers…”
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Cuttlefish conservation: a global review of methods to ameliorate unwanted fishing mortality and other anthropogenic threats to sustainability by Barrett, C J, Bensbai, J, Broadhurst, M K, Bustamante, P, Clark, R, Cooke, G M, Di Cosmo, A, Drerup, C, Escolar, O, Fernández-Álvarez, F A, Ganias, K, Hall, K C, Hanlon, R T, Hernández-Urcera, J, Hua, Q Q H, Lacoue-Labarthe, T, Lewis, J, Lishchenko, F, Maselli, V, Moustahfid, H, Nakajima, R, O’Brien, C E, Parkhouse, L, Pengelly, S, Pierce, G J, Ramírez, J G, Robin, J-P, Sajikumar, K K, Sasikumar, G, Smith, C L, Villanueva, R, Yến, D T H

“…Abstract Cuttlefish are an important global fisheries resource, and their demand is placing increasing pressure on populations in many areas, necessitating…”
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Aqueous methanol eletrolysis using proton conducting membrane for hydrogen production by Sasikumar, Gangadharan, Muthumeenal, Arunachalam, Pethaiah, Sethu Sundar, Nachiappan, Nachiappan, Balaji, Rengarajan

“…In this paper, we present the studies carried out on electrolysis of aqueous methanol for hydrogen production, in a PEM electrolyser consisting of Pt–Ru/C…”
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Sulfonated polyether sulfone-poly(vinylidene fluoride) blend membrane for DMFC applications by Subramanian, M. Sankara, Sasikumar, G

“…Direct methanol fuel cell (DMFC) proton exchange membranes were prepared by blending poly (vinylidene fluoride) (PVDF) with sulfonated poly(ether sulfone)…”
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PD-1 derived CA-170 is an oral immune checkpoint inhibitor that exhibits preclinical anti-tumor efficacy by Sasikumar, Pottayil G., Sudarshan, Naremaddepalli S., Adurthi, Srinivas, Ramachandra, Raghuveer K., Samiulla, Dodderi S., Lakshminarasimhan, Anirudha, Ramanathan, Anuradha, Chandrasekhar, Talapaneni, Dhudashiya, Amit A., Talapati, Sumalatha R., Gowda, Nagesh, Palakolanu, Sreenivasulareddy, Mani, Jiju, Srinivasrao, Bandi, Joseph, David, Kumar, Nigam, Nair, Rashmi, Atreya, Hanudatta S., Gowda, Nagaraj, Ramachandra, Murali

“…Small molecule immune checkpoint inhibitors targeting PD-1 and other pathways may offer advantages including ease of dosing, ability to manage immune-related…”
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Peptide and peptide-inspired checkpoint inhibitors: Protein fragments to cancer immunotherapy by Sasikumar, Pottayil G., Ramachandra, Murali

“…Immune system regained the attention of oncologists and has entered the mainstream for cancer therapy since the discovery of checkpoint antibodies targeting…”
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Evaluation of platinum catalyzed MEAs for PEM fuel cell applications by Pethaiah, S. Sundar, Kalaignan, G. Paruthimal, Sasikumar, G., Ulaganathan, M.

“…In this paper we have evaluated the platinum catalyzed Membrane Electrode Assembly (MEA) by non-equilibrium impregnation reduction method for polymer…”
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Development of nano-catalyzed membrane for PEM fuel cell applications by Pethaiah, S. Sundar, Kalaignan, G. Paruthimal, Sasikumar, G., Ulaganathan, M., Swaminathan, V.

“…Nano-catalyzed membrane with different platinum (Pt) catalyst loadings (0.25 to 1 mg cm −2 ) was investigated for proton exchange membrane fuel cell…”
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Anti-PD-L1 peptide improves survival in sepsis by Shindo, Yuichiro, McDonough, Jacquelyn S., Chang, Katherine C., Ramachandra, Murali, Sasikumar, Pottayil G., Hotchkiss, Richard S.

“…Sepsis remains a leading cause of death in most intensive care units. Many deaths in sepsis are due to nosocomial infections in patients who have entered the…”
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Water transport characteristics of polymer electrolyte membrane fuel cell by Rajalakshmi, N., Jayanth, T.T., Thangamuthu, R., Sasikumar, G., Sridhar, P., Dhathathreyan, K.S.

“…This paper describes the performance of a polymer electrolyte membrane fuel cell (PEMFC) system without humidification of the reactants which consumes a lot of…”
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Small-molecule antagonists of the immune checkpoint pathways: concept to clinic by Sasikumar, Pottayil G, Ramachandra, Murali

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