Search Results - "Sasiela, A."

Cdc42 Regulates E-cadherin Ubiquitination and Degradation through an Epidermal Growth Factor Receptor to Src-mediated Pathway by Shen, Yi, Hirsch, Dianne S., Sasiela, Christy A., Wu, Wen Jin

“…E-cadherins play an essential role in maintaining epithelial polarity by forming Ca2+-dependent adherens junctions between epithelial cells. Here, we report…”
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Identification of inhibitors for MDM2 ubiquitin ligase activity from natural product extracts by a novel high-throughput electrochemiluminescent screen by Sasiela, Christy A, Stewart, David H, Kitagaki, Jirouta, Safiran, Yassamin J, Yang, Yili, Weissman, Allan M, Oberoi, Pankaj, Davydov, Ilia V, Goncharova, Ekaterina, Beutler, John A, McMahon, James B, O'Keefe, Barry R

“…High-throughput screening technologies have revolutionized the manner in which potential therapeutics are identified. Although they are the source of lead…”
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Microstructure characterization and mechanical properties of austenitic Super 304H steel after operation by Purzyńska, H., Golański, G., Sroka, M., Sasiela, A., Zieliński, A.

“…The paper presents the results of testing the microstructure and mechanical properties of austenitic Super 304H steel after approximately 31,000 h of operation…”
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Inhibiting Hdm2 and ubiquitin-activating enzyme: targeting the ubiquitin conjugating system in cancer by Weissman, A M, Yang, Y, Kitagaki, J, Sasiela, C A, Beutler, J A, O'Keefe, B R

“…The ubiquitin conjugating system represents a rich source of potential molecular targets for cancer and other diseases. One target of great interest is the…”
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