Search Results - "Sasiain, María Del Carmen"

Fatty acid oxidation of alternatively activated macrophages prevents foam cell formation, but Mycobacterium tuberculosis counteracts this process via HIF-1α activation by Genoula, Melanie, Marín Franco, José Luis, Maio, Mariano, Dolotowicz, Belén, Ferreyra, Malena, Milillo, M Ayelén, Mascarau, Rémi, Moraña, Eduardo José, Palmero, Domingo, Matteo, Mario, Fuentes, Federico, López, Beatriz, Barrionuevo, Paula, Neyrolles, Olivier, Cougoule, Céline, Lugo-Villarino, Geanncarlo, Vérollet, Christel, Sasiain, María Del Carmen, Balboa, Luciana

“…The ability of Mycobacterium tuberculosis (Mtb) to persist inside host cells relies on metabolic adaptation, like the accumulation of lipid bodies (LBs) in the…”
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A Phenotypic Characterization of Two Isolates of a Multidrug-Resistant Outbreak Strain of Mycobacterium tuberculosis with Opposite Epidemiological Fitness by Dai, Zhangyan, Chen, Zhuang, Sasiain, María del Carmen, Ritacco, Viviana, de la Barrera, Silvia S., Soria, Marcelo, Duran, Rosario, Bigi, Fabiana, Wang, Zhilin, Yu, Ting, López, Beatriz, Blanco, Federico Carlos, Zhang, Qi, Lima, Analía, Bigi, María Mercedes, Bei, Jinlong, Cataldi, Angel Adrián

“…Tuberculosis (TB) is an infectious disease, caused by Mycobacterium tuberculosis, primarily affecting the lungs. The M. tuberculosis strain of the Haarlem…”
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Mycobacterium tuberculosis multidrug resistant strain M induces an altered activation of cytotoxic CD8+ T cells by Geffner, Laura, Basile, Juan Ignacio, Yokobori, Noemí, Kviatcovsky, Denise, Sabio y García, Carmen, Ritacco, Viviana, López, Beatriz, Sasiain, María del Carmen, de la Barrera, Silvia

“…In human tuberculosis (TB), CD8+ T cells contribute to host defense by the release of Th1 cytokines and the direct killing of Mycobacterium tuberculosis…”
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Outbreaks of Mycobacterium tuberculosis MDR strains differentially induce neutrophil respiratory burst involving lipid rafts, p38 MAPK and Syk by Romero, María Mercedes, Basile, Juan Ignacio, López, Beatriz, Ritacco, Viviana, Barrera, Lucía, Sasiain, María del Carmen, Alemán, Mercedes

“…Neutrophils (PMN) are the first cells to infiltrate the lung after infection, and they play a significant protective role in the elimination of pathogen, by…”
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Differential Expression of Immunogenic Proteins on Virulent Mycobacterium tuberculosis Clinical Isolates by Schierloh, Pablo, Klepp, Laura, Vazquez, Camila, Rocha, Roxana Valeria, Blanco, Federico Carlos, Balboa, Luciana, López, Beatriz, Ritacco, Viviana, Bigi, Fabiana, Sasiain, María del Carmen

“…Molecular epidemiology has revealed that Mycobacterium tuberculosis (Mtb), formerly regarded as highly conserved species, displays a considerable degree of…”
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Two genetically-related multidrug-resistant Mycobacterium tuberculosis strains induce divergent outcomes of infection in two human macrophage models by Yokobori, Noemí, López, Beatriz, Geffner, Laura, Sabio y García, Carmen, Schierloh, Pablo, Barrera, Lucía, de la Barrera, Silvia, Sakai, Shunsuke, Kawamura, Ikuo, Mitsuyama, Masao, Ritacco, Viviana, del Carmen Sasiain, María

“…► Two closely related M. tuberculosis strains with divergent epidemiology were studied. ► Outbreak strain grew slower than unique strain in monocyte derived…”
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Massive plasmablast response elicited in the acute phase of hantavirus pulmonary syndrome by García, Marina, Iglesias, Ayelén, Landoni, Verónica I., Bellomo, Carla, Bruno, Agostina, Córdoba, María Teresa, Balboa, Luciana, Fernández, Gabriela C., Sasiain, María del Carmen, Martínez, Valeria P., Schierloh, Pablo

“…Summary Beside its key diagnostic value, the humoral immune response is thought to play a protective role in hantavirus pulmonary syndrome. However, little is…”
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Elevated glycolytic metabolism of monocytes limits the generation of HIF1A-driven migratory dendritic cells in tuberculosis by Maio, Mariano, Barros, Joaquina, Joly, Marine, Vahlas, Zoi, Marín Franco, José Luis, Genoula, Melanie, Monard, Sarah C, Vecchione, María Belén, Fuentes, Federico, Gonzalez Polo, Virginia, Quiroga, María Florencia, Vermeulen, Mónica, Vu Manh, Thien-Phong, Argüello, Rafael J, Inwentarz, Sandra, Musella, Rosa, Ciallella, Lorena, González Montaner, Pablo, Palmero, Domingo, Lugo Villarino, Geanncarlo, Sasiain, María Del Carmen, Neyrolles, Olivier, Vérollet, Christel, Balboa, Luciana

“…During tuberculosis (TB), migration of dendritic cells (DCs) from the site of infection to the draining lymph nodes is known to be impaired, hindering the…”
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Formation of Foamy Macrophages by Tuberculous Pleural Effusions Is Triggered by the Interleukin-10/Signal Transducer and Activator of Transcription 3 Axis through ACAT Upregulation by Genoula, Melanie, Marín Franco, José Luis, Dupont, Maeva, Kviatcovsky, Denise, Milillo, Ayelén, Schierloh, Pablo, Moraña, Eduardo Jose, Poggi, Susana, Palmero, Domingo, Mata-Espinosa, Dulce, González-Domínguez, Erika, León Contreras, Juan Carlos, Barrionuevo, Paula, Rearte, Bárbara, Córdoba Moreno, Marlina Olyissa, Fontanals, Adriana, Crotta Asis, Agostina, Gago, Gabriela, Cougoule, Céline, Neyrolles, Olivier, Maridonneau-Parini, Isabelle, Sánchez-Torres, Carmen, Hernández-Pando, Rogelio, Vérollet, Christel, Lugo-Villarino, Geanncarlo, Sasiain, María Del Carmen, Balboa, Luciana

“…The ability of (Mtb) to persist in its human host relies on numerous immune evasion strategies, such as the deregulation of the lipid metabolism leading to the…”
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Effect of the BTK inhibitor ibrutinib on macrophage- and γδ T cell-mediated response against Mycobacterium tuberculosis by Colado, Ana, Genoula, Melanie, Cougoule, Céline, Marín Franco, José L., Almejún, María B., Risnik, Denise, Kviatcovsky, Denise, Podaza, Enrique, Elías, Esteban E., Fuentes, Federico, Maridonneau-Parini, Isabelle, Bezares, Fernando R., Fernandez Grecco, Horacio, Cabrejo, María, Jancic, Carolina, Sasiain, María del Carmen, Giordano, Mirta, Gamberale, Romina, Balboa, Luciana, Borge, Mercedes

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Mycobacterium tuberculosis Multidrug-Resistant Strain M Induces Low IL-8 and Inhibits TNF-α Secretion by Bronchial Epithelial Cells Altering Neutrophil Effector Functions by Kviatcovsky, Denise, Rivadeneyra, Leonardo, Balboa, Luciana, Yokobori, Noemí, López, Beatriz, Ritacco, Viviana, Schattner, Mirta, Sasiain, María del Carmen, de la Barrera, Silvia

“…M strain, the most prevalent multidrug-resistant strain of Mycobacterium tuberculosis (Mtb) in Argentina, has mounted mechanisms to evade innate immune…”
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Tuberculosis Exacerbates HIV-1 Infection through IL-10/STAT3-Dependent Tunneling Nanotube Formation in Macrophages by Souriant, Shanti, Balboa, Luciana, Dupont, Maeva, Pingris, Karine, Kviatcovsky, Denise, Cougoule, Céline, Lastrucci, Claire, Bah, Aicha, Gasser, Romain, Poincloux, Renaud, Raynaud-Messina, Brigitte, Al Saati, Talal, Inwentarz, Sandra, Poggi, Susana, Moraña, Eduardo Jose, González-Montaner, Pablo, Corti, Marcelo, Lagane, Bernard, Vergne, Isabelle, Allers, Carolina, Kaushal, Deepak, Kuroda, Marcelo J., Sasiain, Maria del Carmen, Neyrolles, Olivier, Maridonneau-Parini, Isabelle, Lugo-Villarino, Geanncarlo, Vérollet, Christel

“…The tuberculosis (TB) bacillus, Mycobacterium tuberculosis (Mtb), and HIV-1 act synergistically; however, the mechanisms by which Mtb exacerbates HIV-1…”
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Tuberculosis is associated with expansion of a motile, permissive and immunomodulatory CD16＂ monocyte population via the IL-10/STAT3 axis by Lastrucci, Claire, Bénard, Alan, Balboa, Luciana, Pingris, Karine, Souriant, Shanti, Poincloux, Renaud, Al Saati, Talal, Rasolofo, Voahangy, González-Montaner, Pablo, Inwentarz, Sandra, Moraña, Eduardo Jose, Kondova, Ivanela, Verreck, Frank AW, Sasiain, Maria del Carmen, Neyrolles, Olivier, Maridonneau-Parini, Isabelle, Lugo-Villarino, Geanncarlo, Cougoule, Céline

“…The human CD14＋ monocyte compartment is composed by two subsets based on CD16 expression. We previ- ously reported that this compartment is perturbed in…”
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B Cells Producing Type I IFN Modulate Macrophage Polarization in Tuberculosis by Bénard, Alan, Sakwa, Imme, Schierloh, Pablo, Colom, André, Mercier, Ingrid, Tailleux, Ludovic, Jouneau, Luc, Boudinot, Pierre, Al-Saati, Talal, Lang, Roland, Rehwinkel, Jan, Loxton, Andre G, Kaufmann, Stefan H E, Anton-Leberre, Véronique, O'Garra, Anne, Sasiain, Maria Del Carmen, Gicquel, Brigitte, Fillatreau, Simon, Neyrolles, Olivier, Hudrisier, Denis

“…In addition to their well-known function as antibody-producing cells, B lymphocytes can markedly influence the course of infectious or noninfectious diseases…”
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Monocyte-derived dendritic cells early exposed to Mycobacterium tuberculosis induce an enhanced T helper 17 response and transfer mycobacterial antigens by Balboa, Luciana, Kviatcovsky, Denise, Schierloh, Pablo, García, Marina, de la Barrera, Silvia, Sasiain, María del Carmen

“…Abstract Tuberculosis (TB) is a complex disease, and the success of the bacterium depends on its ability to evade the immune response. Previously, we…”
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Diverging biological roles among human monocyte subsets in the context of tuberculosis infection by Balboa, Luciana, Barrios-Payan, Jorge, González-Domínguez, Erika, Lastrucci, Claire, Lugo-Villarino, Geanncarlo, Mata-Espinoza, Dulce, Schierloh, Pablo, Kviatcovsky, Denise, Neyrolles, Olivier, Maridonneau-Parini, Isabelle, Sánchez-Torres, Carmen, Sasiain, María del Carmen, Hernández-Pando, Rogelio

“…Circulating monocytes (Mo) play an essential role in the host immune response to chronic infections. We previously demonstrated that CD16(pos) Mo were expanded…”
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C5aR contributes to the weak Th1 profile induced by an outbreak strain of Mycobacterium tuberculosis by Sabio y García, Carmen Alejandra, Yokobori, Noemí, Basile, Juan Ignacio, Balboa, Luciana, González, Alejandra, López, Beatriz, Ritacco, Viviana, Barrera, Silvia de la, Sasiain, María del Carmen

“…Abstract C5a anaphylatoxin is a component of the complement system involved in the modulation of T-cell polarization. Herein we investigated whether C5a…”
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Host-Derived Lipids from Tuberculous Pleurisy Impair Macrophage Microbicidal-Associated Metabolic Activity by Marín Franco, José Luis, Genoula, Melanie, Corral, Dan, Duette, Gabriel, Ferreyra, Malena, Maio, Mariano, Dolotowicz, María Belén, Aparicio-Trejo, Omar Emiliano, Patiño-Martínez, Eduardo, Charton, Alison, Métais, Arnaud, Fuentes, Federico, Soldan, Vanessa, Moraña, Eduardo José, Palmero, Domingo, Ostrowski, Matías, Schierloh, Pablo, Sánchez-Torres, Carmen, Hernández-Pando, Rogelio, Pedraza-Chaverri, José, Rombouts, Yoann, Hudrisier, Denis, Layre, Emilie, Vérollet, Christel, Maridonneau-Parini, Isabelle, Neyrolles, Olivier, Sasiain, María Del Carmen, Lugo-Villarino, Geanncarlo, Balboa, Luciana

“…Mycobacterium tuberculosis (Mtb) regulates the macrophage metabolic state to thrive in the host, yet the responsible mechanisms remain elusive. Macrophage…”
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The C-Type Lectin Receptor DC-SIGN Has an Anti-Inflammatory Role in Human M(IL-4) Macrophages in Response to Mycobacterium tuberculosis by Lugo-Villarino, Geanncarlo, Troegeler, Anthony, Balboa, Luciana, Lastrucci, Claire, Duval, Carine, Mercier, Ingrid, Bénard, Alan, Capilla, Florence, Al Saati, Talal, Poincloux, Renaud, Kondova, Ivanela, Verreck, Frank A W, Cougoule, Céline, Maridonneau-Parini, Isabelle, Sasiain, Maria Del Carmen, Neyrolles, Olivier

“…DC-SIGN (CD209/CLEC4L) is a C-type lectin receptor (CLR) that serves as a reliable cell-surface marker of interleukin 4 (IL-4)-activated human macrophages…”
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Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages by Dupont, Maeva, Souriant, Shanti, Balboa, Luciana, Vu Manh, Thien-Phong, Pingris, Karine, Rousset, Stella, Cougoule, Céline, Rombouts, Yoann, Poincloux, Renaud, Ben Neji, Myriam, Allers, Carolina, Kaushal, Deepak, Kuroda, Marcelo J, Benet, Susana, Martinez-Picado, Javier, Izquierdo-Useros, Nuria, Sasiain, Maria Del Carmen, Maridonneau-Parini, Isabelle, Neyrolles, Olivier, Vérollet, Christel, Lugo-Villarino, Geanncarlo

“…While tuberculosis (TB) is a risk factor in HIV-1-infected individuals, the mechanisms by which (Mtb) worsens HIV-1 pathogenesis remain scarce. We showed that…”
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