Search Results - "Sasi, Binu K"

Molecular mechanism of monoamine oxidase A gene regulation under inflammation and ischemia‐like conditions: key roles of the transcription factors GATA2, Sp1 and TBP by Gupta, Vinayak, Khan, Abrar A., Sasi, Binu K., Mahapatra, Nitish R.

“…Monoamine oxidase A (MAOA) plays important roles in the pathogenesis of several neurological and cardiovascular disorders. The mechanism of transcriptional…”
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Transcriptional Regulation of the Novel Monoamine Oxidase Renalase: Crucial Roles of Transcription Factors Sp1, STAT3, and ZBP89 by Sonawane, Parshuram J, Gupta, Vinayak, Sasi, Binu K, Kalyani, Ananthamohan, Natarajan, Bhargavi, Khan, Abrar A, Sahu, Bhavani S, Mahapatra, Nitish R

“…Renalase, a novel monoamine oxidase, is emerging as an important regulator of cardiovascular, metabolic, and renal diseases. However, the mechanism of…”
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SHP1 Deficiency Is Responsible for the Constitutive Activation of the BCR Pathway in GCB DLBCL by Sasi, Binu K, Turkalj, Sven, Kalkan, Hilal, Porro, Fabiola, Bojnik, Engin, Pyrzynska, Beata, Zerrouqi, Abdessamad, Bobrowicz, Malgorzata, Winiarska, Magdalena, Priebe, Valdemar, Bertoni, Francesco, Mansouri, Larry, Rosenquist, Richard, Efremov, Dimitar G

“…Functional and transcriptional profiling studies have identified a subset of diffuse large B cell lymphoma (DLBCL) tumors that rely on B cell receptor (BCR)…”
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BCR signaling inhibitors differ in their ability to overcome Mcl-1–mediated resistance of CLL B cells to ABT-199 by Bojarczuk, Kamil, Sasi, Binu K., Gobessi, Stefania, Innocenti, Idanna, Pozzato, Gabriele, Laurenti, Luca, Efremov, Dimitar G.

“…The Bcl-2 antagonist ABT-199 (venetoclax) has demonstrated promising clinical activity in patients with chronic lymphocytic leukemia (CLL). ABT-199 is strongly…”
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Functional promoter polymorphisms govern differential expression of HMG-CoA reductase gene in mouse models of essential hypertension by Sonawane, Parshuram J, Sahu, Bhavani S, Sasi, Binu K, Geedi, Parimala, Lenka, Govinda, Mahapatra, Nitish R

“…3-Hydroxy-3-methylglutaryl-coenzyme A [HMG-CoA] reductase gene (Hmgcr) is a susceptibility gene for essential hypertension. Sequencing of the Hmgcr locus in…”
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Corrigendum to “Coordinated Transcriptional Regulation of Hspa1a Gene by Multiple Transcription Factors: Crucial Roles for HSF-1, NF-Y, NF-κB, and CREB” [J. Mol. Biol. (2014) 426, 116–135] by Sasi, Binu K., Sonawane, Parshuram J., Gupta, Vinayak, Sahu, Bhavani S., Mahapatra, Nitish R.

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Inhibition of SYK or BTK augments venetoclax sensitivity in SHP1-negative/BCL-2-positive diffuse large B-cell lymphoma by Sasi, Binu K., Martines, Claudio, Xerxa, Elena, Porro, Fabiola, Kalkan, Hilal, Fazio, Rosa, Turkalj, Sven, Bojnik, Engin, Pyrzynska, Beata, Stachura, Joanna, Zerrouqi, Abdessamad, Bobrowicz, Małgorzata, Winiarska, Magdalena, Priebe, Valdemar, Bertoni, Francesco, Mansouri, Larry, Rosenquist, Richard, Efremov, Dimitar G.

“…The BCL-2 inhibitor venetoclax has only limited activity in DLBCL despite frequent BCL-2 overexpression. Since constitutive activation of the B cell receptor…”
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Coordinated Transcriptional Regulation of Hspa1a Gene by Multiple Transcription Factors: Crucial Roles for HSF-1, NF-Y, NF-κB, and CREB by Sasi, Binu K., Sonawane, Parshuram J., Gupta, Vinayak, Sahu, Bhavani S., Mahapatra, Nitish R.

“…Although the transcript level of inducible heat shock protein 70.3 (Hsp70.3, also known as Hspa1a) is altered in various disease states, its transcriptional…”
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BDA-366, a putative Bcl-2 BH4 domain antagonist, induces apoptosis independently of Bcl-2 in a variety of cancer cell models by Vervloessem, Tamara, Sasi, Binu K., Xerxa, Elena, Karamanou, Spyridoula, Kale, Justin, La Rovere, Rita M., Chakraborty, Supriya, Sneyers, Flore, Vogler, Meike, Economou, Anastassios, Laurenti, Luca, Andrews, David W., Efremov, Dimitar G., Bultynck, Geert

“…Several cancer cell types, including chronic lymphocytic leukemia (CLL) and diffuse large B-cell lymphoma (DLBCL) upregulate antiapoptotic Bcl-2 to cope with…”
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Functional promoter polymorphisms direct the expression of cystathionine gamma-lyase gene in mouse models of essential hypertension by Gupta, Vinayak, Kapopara, Piyushkumar R, Khan, Abrar A, Arige, Vikas, Subramanian, Lakshmi, Sonawane, Parshuram J, Sasi, Binu K, Mahapatra, Nitish R

“…Abstract Despite the well-known role of cystathionine γ-lyase (Cth) in cardiovascular pathophysiology, transcriptional regulation of Cth remains incompletely…”
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Enhancement in the efficiency of polymerase chain reaction by TiO2 nanoparticles: crucial role of enhanced thermal conductivity by Abdul Khaliq, R, Sonawane, Parshuram J, Sasi, Binu K, Sahu, Bhavani S, Pradeep, T, Das, Sarit K, Mahapatra, Nitish R

“…Improvement of the specificity and efficiency of the polymerase chain reaction (PCR) by nanoparticles is an emerging area of research. We observed that TiO(2)…”
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Molecular interactions of the physiological anti-hypertensive peptide catestatin with the neuronal nicotinic acetylcholine receptor by Sahu, Bhavani S, Mohan, Jagan, Obbineni, Jagan M, Sahu, Giriraj, Singh, Pradeep K, Sonawane, Parshuram J, Sasi, Binu K, Allu, Prasanna K R, Maji, Samir K, Bera, Amal K, Senapati, Sanjib, Mahapatra, Nitish R

“…Catestatin (CST), a chromogranin-A-derived peptide, is a potent endogenous inhibitor of the neuronal nicotinic acetylcholine receptor (nAChR). It exerts an…”
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Functional genetic variants of the catecholamine-release-inhibitory peptide catestatin in an Indian population: allele-specific effects on metabolic traits by Sahu, Bhavani S, Obbineni, Jagan M, Sahu, Giriraj, Allu, Prasanna K R, Subramanian, Lakshmi, Sonawane, Parshuram J, Singh, Pradeep K, Sasi, Binu K, Senapati, Sanjib, Maji, Samir K, Bera, Amal K, Gomathi, Balashankar S, Mullasari, Ajit S, Mahapatra, Nitish R

“…Catestatin (CST), a chromogranin A (CHGA)-derived peptide, is a potent inhibitor of catecholamine release from adrenal chromaffin cells and postganglionic…”
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Functional Genetic Variants of the Catecholamine-Release-Inhibitory Peptide Catestatin in an Indian Population by Sahu, Bhavani S., Obbineni, Jagan M., Sahu, Giriraj, Allu, Prasanna K.R., Subramanian, Lakshmi, Sonawane, Parshuram J., Singh, Pradeep K., Sasi, Binu K., Senapati, Sanjib, Maji, Samir K., Bera, Amal K., Gomathi, Balashankar S., Mullasari, Ajit S., Mahapatra, Nitish R.

“…Catestatin (CST), a chromogranin A (CHGA)-derived peptide, is a potent inhibitor of catecholamine release from adrenal chromaffin cells and postganglionic…”
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Serum IgM Activates BCR Signaling Pathways and Increases Survival of Chronic Lymphocytic Leukemia B Cells by Gobessi, Stefania, Sasi, Binu K, Laurenti, Luca, Efremov, Dimitar G

“…Serum IgM would be expected to bind chronic lymphocytic leukemia B cells through two different mechanisms. The first mechanism is via interactions between the…”
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The Bcl-2 BH4 Antagonist Bda-366 Induces Apoptosis in CLL and DLBCL Cells through a Bcl-2 Independent Mechanism by Sasi, Binu K, Vervloessem, Tamara, Gobessi, Stefania, Innocenti, Idanna, Laurenti, Luca, Bultynck, Geert, Efremov, Dimitar G

“…Overexpression of the antiapoptotic protein Bcl-2 is considered primarily responsible for the increased apoptosis resistance and prolonged survival of the…”
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FcμR Triggering Activates BCR Signaling Pathways and Increases Survival of CLL Cells by Gobessi, Stefania, Sasi, Binu K, Pozzato, Gabriele, Innocenti, Idanna, Laurenti, Luca, Efremov, Dimitar G

“…Soluble IgM was recently shown to activate B cell receptor (BCR) signaling pathways in chronic lymphocytic leukemia (CLL) B cells and protect them from…”
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Inhibition of SYK More Effectively Overcomes MCL-1 Mediated ABT-199 Resistance of BCR-Stimulated CLL Cells Than Inhibition of BTK or PI3Kdelta by Bojarczuk, Kamil, Sasi, Binu K, Gobessi, Stefania, Innocenti, Idanna, Laurenti, Luca, Efremov, Dimitar G

“…The selective Bcl-2 antagonist ABT-199 has demonstrated promising clinical activity in patients with CLL. This drug is strongly cytotoxic against unstimulated…”
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Molecular mechanism of monoamine oxidase A gene regulation under inflammation and ischemia‐like conditions: key roles of the transcription factors GATA 2, Sp1 and TBP by Gupta, Vinayak, Khan, Abrar A., Sasi, Binu K., Mahapatra, Nitish R.

“…Abstract Monoamine oxidase A ( MAOA ) plays important roles in the pathogenesis of several neurological and cardiovascular disorders. The mechanism of…”
Get full text

Molecular interactions of the physiological anti-hypertensive peptide catestatin with the neuronal nicotinic acetylcholine receptor by Sahu, Bhavani S., Mohan, Jagan, Sahu, Giriraj, Singh, Pradeep K., Sonawane, Parshuram J., Sasi, Binu K., Allu, Prasanna K. R., Maji, Samir K., Bera, Amal K., Senapati, Sanjib, Mahapatra, Nitish R.

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