Search Results - "Sasawatari, Shigemi"

The inhibitory NK receptor Ly49Q protects plasmacytoid dendritic cells from pyroptotic cell death by Sasawatari, Shigemi, Karyu, Hitomi, Nguyen Tien, Dat, Furuyama-Tanaka, Kaori, Toyama-Sorimachi, Noriko

“…•CpG-ODN stimulation induced cell death in Ly49Q-deficient BMDCs in both in vivo and in vitro.•Ly49Q-deficient BMDCs secreted increased amounts of IL-1β upon…”
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Natural killer cells impede the engraftment of cardiomyocytes derived from induced pluripotent stem cells in syngeneic mouse model by Nakamura, Yuki, Miyagawa, Shigeru, Yoshida, Shohei, Sasawatari, Shigemi, Toyofuku, Toshihiko, Toda, Koichi, Sawa, Yoshiki

“…Transplantation of cardiomyocytes derived from induced pluripotent stem cell (iPSC-CMs) is a promising approach for increasing functional CMs during end-stage…”
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The Solute Carrier Family 15A4 Regulates TLR9 and NOD1 Functions in the Innate Immune System and Promotes Colitis in Mice by Sasawatari, Shigemi, Okamura, Tadashi, Kasumi, Eiji, Tanaka–Furuyama, Kaori, Yanobu–Takanashi, Rieko, Shirasawa, Senji, Kato, Norihiro, Toyama–Sorimachi, Noriko

“…Background & Aims Solute carrier family 15 (SLC15) A4 is a proton-coupled histidine and oligopeptide cotransporter expressed by the immune and nervous systems…”
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Predicting the Efficacy and Safety of TACTICs (Tumor Angiogenesis-Specific CAR-T Cells Impacting Cancers) Therapy for Soft Tissue Sarcoma Patients by Fujiwara, Kento, Sasawatari, Shigemi, Nakai, Sho, Imaeda, Keisuke, Nagai, Seina, Matsuno, Yoshihiro, Hatanaka, Kanako, Hatanaka, Yutaka, Takenaka, Satoshi, Okada, Naoki

“…Soft tissue sarcomas (STSs) are heterogeneous and aggressive malignancies with few effective therapies available. We have developed T cells expressing a…”
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Immunological quality and performance of tumor vessel-targeting CAR-T cells prepared by mRNA-EP for clinical research by Inoo, Kanako, Inagaki, Ryo, Fujiwara, Kento, Sasawatari, Shigemi, Kamigaki, Takashi, Nakagawa, Shinsaku, Okada, Naoki

“…We previously reported that tumor vessel-redirected T cells, which were genetically engineered with chimeric antigen receptor (CAR) specific for vascular…”
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The Ly49Q Receptor Plays a Crucial Role in Neutrophil Polarization and Migration by Regulating Raft Trafficking by Sasawatari, Shigemi, Yoshizaki, Mariko, Taya, Choji, Tazawa, Aya, Furuyama-Tanaka, Kaori, Yonekawa, Hiromichi, Dohi, Taeko, Makrigiannis, Andrew P., Sasazuki, Takehiko, Inaba, Kayo, Toyama-Sorimachi, Noriko

“…Neutrophils rapidly undergo polarization and directional movement to infiltrate the sites of infection and inflammation. Here, we show that an inhibitory MHC I…”
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Spatiotemporal regulation of intracellular trafficking of Toll-like receptor 9 by an inhibitory receptor, Ly49Q by Yoshizaki, Mariko, Tazawa, Aya, Kasumi, Eiji, Sasawatari, Shigemi, Itoh, Kenji, Dohi, Taeko, Sasazuki, Takehiko, Inaba, Kayo, Makrigiannis, Andrew P., Toyama-Sorimachi, Noriko

“…Toll-like receptor (TLR) 9 recognizes unmethylated microorganismal cytosine guanine dinucleotide (CpG) DNA and elicits innate immune responses. However, the…”
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LRRK2 regulates endoplasmic reticulum–mitochondrial tethering through the PERK‐mediated ubiquitination pathway by Toyofuku, Toshihiko, Okamoto, Yuki, Ishikawa, Takako, Sasawatari, Shigemi, Kumanogoh, Atsushi

“…Mutations in the leucine‐rich repeat kinase 2 ( LRRK2 ) gene are the most common cause of familial Parkinson's disease (PD). Impaired mitochondrial function is…”
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Blockade of N -Glycosylation Promotes Antitumor Immune Response of T Cells by Sasawatari, Shigemi, Okamoto, Yuki, Kumanogoh, Atsushi, Toyofuku, Toshihiko

“…Adoptive cellular therapy and its derivative, chimeric AgR T cell therapy, have achieved significant progress against cancer. Major barriers persist, however,…”
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Leucine-Rich Repeat Kinase 1 Regulates Autophagy through Turning On TBC1D2-Dependent Rab7 Inactivation by Toyofuku, Toshihiko, Morimoto, Keiko, Sasawatari, Shigemi, Kumanogoh, Atsushi

“…Autophagy is a conserved process that enables catabolic and degradative pathways. Rab family proteins, which are active in the GTP-bound form, regulate the…”
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LRRK2 regulates endoplasmic reticulum–mitochondrial tethering through the PERK‐mediated ubiquitination pathway by Toyofuku, Toshihiko, Okamoto, Yuki, Ishikawa, Takako, Sasawatari, Shigemi, Kumanogoh, Atsushi

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Erratum To: LRRK2 regulates endoplasmic reticulum–mitochondrial tethering through the PERK‐mediated ubiquitination pathway by Toyofuku, Toshihiko, Okamoto, Yuki, Ishikawa, Takako, Sasawatari, Shigemi, Kumanogoh, Atsushi

“…Graphical Abstract…”
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LRRK 2 regulates endoplasmic reticulum–mitochondrial tethering through the PERK ‐mediated ubiquitination pathway by Toyofuku, Toshihiko, Okamoto, Yuki, Ishikawa, Takako, Sasawatari, Shigemi, Kumanogoh, Atsushi

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LRRK 2 regulates endoplasmic reticulum–mitochondrial tethering through the PERK ‐mediated ubiquitination pathway by Toyofuku, Toshihiko, Okamoto, Yuki, Ishikawa, Takako, Sasawatari, Shigemi, Kumanogoh, Atsushi

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Correction for Toyofuku et al., "Leucine-Rich Repeat Kinase 1 Regulates Autophagy through Turning On TBC1D2-Dependent Rab7 Inactivation" by Toyofuku, Toshihiko, Morimoto, Keiko, Sasawatari, Shigemi, Kumanogoh, Atsusi

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3,3',4,4',5$ -Pentachlorobiphenyl Inhibits Drug Efflux Through P-Glycoprotein in KB-3 Cells Expressing Mutant Human P-Glycoprotein by Fujise, Hiroshi, Sasawatari, Shigemi, Annoura, Takeshi, Ikeda, Teruo, Ueda, Kazumitsu

“…The effects on the drug efflux of $3,3',4,4',5$ -pentachlorobiphenyl (PCB-126), the most toxic of all coplanar polychlorinated biphenyls (Co-PCBs), were…”
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Effect of PCB-126 on intracellular accumulation and transepithelial transport of vinblastine in LLC-PK1 and its transformant cells expressing human P-glycoprotein by Sasawatari, S. (Azabu Univ., Sagamihara, Kanagawa (Japan). School of Veterinary Medicine), Toki, M, Horie, T, Nakano, Y, Ikeda, T, Ueda, K, Fujise, H

“…The effects of 3, 3', 4, 4', 5-pentachlorobiphenyl (PCB-126), which is the most toxic congener of coplanar polychlorinated biphenyls (Co-PCBs), on…”
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The innate immune system in host mice targets cells with allogenic mitochondrial DNA by Ishikawa, Kaori, Toyama-Sorimachi, Noriko, Nakada, Kazuto, Morimoto, Mami, Imanishi, Hirotake, Yoshizaki, Mariko, Sasawatari, Shigemi, Niikura, Mamoru, Takenaga, Keizo, Yonekawa, Hiromichi, Hayashi, Jun-Ichi

“…Mitochondrial DNA (mtDNA) has been proposed to be involved in respiratory function, and mtDNA mutations have been associated with aging, tumors, and various…”
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Efficient priming and expansion of antigen-specific CD8 T cells by a novel cell-based artificial APC by Sasawatari, Shigemi, Tadaki, Toshimasa, Isogai, Manami, Takahara, Masashi, Nieda, Mie, Kakimi, Kazuhiro

“…The ex vivo priming and expansion of human CTL by APC, such as autologous monocyte‐derived dendritic cells (DC), has the potential for use in immunotherapy for…”
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Abstract 11324: Immunologic Impacts of Natural Killer Cell-Related Innate Immune Rejection Mediated by CD226 and NKG2D on the Engraftment of Syngeneic Cardiomyocyte Derived From Induced Pluripotent Stem Cell by Nakamura, Yuki, Miyagawa, Shigeru, Yoshida, Shohei, Sasawatari, Shigemi, Toyofuku, Toshihiko, Sawa, Yoshiki

“…BackgroundFor clinical application of induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM), immune response to transplants is of great concern;…”
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