Search Results - "Sasamata, M"

Marked anti-tumour activity of the combination of YM155, a novel survivin suppressant, and platinum-based drugs by Iwasa, T, Okamoto, I, Takezawa, K, Yamanaka, K, Nakahara, T, Kita, A, Koutoku, H, Sasamata, M, Hatashita, E, Yamada, Y, Kuwata, K, Fukuoka, M, Nakagawa, K

“…Background: Survivin, a member of the inhibitor of apoptosis protein family, is an attractive target for cancer therapy. We have now investigated the effects…”
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Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family by Endres, M, Namura, S, Shimizu-Sasamata, M, Waeber, C, Zhang, L, Gómez-Isla, T, Hyman, B T, Moskowitz, M A

“…Inhibitors of apoptosis and of excitotoxic cell death reduce brain damage after transient and permanent middle cerebral artery occlusion. We compared the…”
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Telmisartan has the strongest binding affinity to angiotensin II type 1 receptor: comparison with other angiotensin II type 1 receptor blockers by Kakuta, H, Sudoh, K, Sasamata, M, Yamagishi, S

“…There is a growing body of evidence that the renin-angiotensin system (RAS) plays a pivotal role in the pathogenesis of cardiovascular diseases. Indeed, large…”
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Effects of serotonin 5‐HT3 receptor antagonists on stress‐induced colonic hyperalgesia and diarrhoea in rats: a comparative study with opioid receptor agonists, a muscarinic receptor antagonist and a synthetic polymer by Hirata, T., Keto, Y., Nakata, M., Takeuchi, A., Funatsu, T., Akuzawa, S., Sasamata, M., Miyata, K.

“…In this study, we examined the effects of serotonin (5‐HT)3 receptor antagonists (5‐HT3RAs) including ramosetron, alosetron, and cilansetron on colonic…”
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Pharmacological profile of ramosetron, a novel therapeutic agent for IBS by Hirata, T, Funatsu, T, Keto, Y, Nakata, M, Sasamata, M

“…Ramosetron is a potent and selective serotonin (5-HT)(3) receptor antagonist that has been shown to affect abnormal colonic function and abdominal pain in…”
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Real-time blood-pool images of contrast enhanced ultrasound with definity in the detection of tumour nodules in the liver by MARUYAMA, H, MATSUTANI, S, SAISHO, H, MINE, Y, KAMIYAMA, N, HIRATA, T, SASAMATA, M

“…Lower mechanical index (MI) technique with newer microbubble agents has been introduced into clinical practice as a newer ultrasound (US) imaging. However, the…”
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Effects of nitric oxide synthase gene knockout on neurotransmitter release in vivo by Kano, T, Shimizu-Sasamata, M, Huang, P.L, Moskowitz, M.A, Lo, E.H

“…Nitric oxide serves as a diffusible messenger within the neuronal networks of the brain. Recent studies have suggested that nitric oxide may amplify…”
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Novel AMPA Receptor Antagonists:  Synthesis and Structure−Activity Relationships of 1-Hydroxy-7-(1H-imidazol-1-yl)-6-nitro-2,3(1H,4H)- quinoxalinedione and Related Compounds by Ohmori, Junya, Shimizu-Sasamata, Masao, Okada, Masamichi, Sakamoto, Shuichi

“…As part of our study of novel antagonists at the α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) subtype of excitatory amino acid (EAA) receptors and…”
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Post-stroke atorvastatin treatment reduces neurological deficits and mortality rate in the stroke-prone spontaneously hypertensive rat by Hayashi, Aska, Suzuki, Masanori, Ogawa, Yumiko, Sonoda, Rie, Sasamata, Masao

“…Several large clinical trials have demonstrated that 3‐hydroxy‐3‐methylglutaryl (HMG)‐CoA reductase inhibitors decreased the incidence of stroke independently…”
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Neuroprotective effect of YM90K, a novel AMPA/kainate receptor antagonist, in focal cerebral ischemia in cats by Yatsugi, S, Takahashi, M, Kawasaki-Yatsugi, S, Koshiya, K, Sakamoto, S, Uematsu, D, Shimizu-Sasamata, M

“…We studied the effect of a novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)/kainate antagonist, YM90K [6-(1H-imidazol-1-yl)-7-nitro-2,…”
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340 POSTER Anti-tumor activity of YM753, a histone deacetylase inhibitor, against hormone refractory prostate cancer by Mori, M, Shindoh, N, Amino, N, Kita, A, Terada, Y, Taniguchi, M, Sohda, K, Sowa, Y, Sakai, T, Sasamata, M

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353 POSTER Therapeutic potential of YM155 alone and in combination with chemotherapeutics against human non-small cell lung cancer in carcinoma xenograft models by Yamanaka, K, Nakahara, T, Kita, A, Miyoshi, S, Noda, A, Takeuchi, M, Kinoyama, I, Koutoku, H, Nishimura, S, Sasamata, M

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Attenuated Neurotransmitter Release and Spreading Depression-Like Depolarizations after Focal Ischemia in Mutant Mice with Disrupted Type I Nitric Oxide Synthase Gene by Shimizu-Sasamata, Masao, Bosque-Hamilton, Prince, Huang, Paul L, Moskowitz, Michael A, Lo, Eng H

“…Nitric oxide (NO) plays a complex role in the pathophysiology of cerebral ischemia. In this study, mutant mice with disrupted type I (neuronal) NO synthase…”
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6-(1H-Imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione hydrochloride (YM90K) and related compounds: structure-activity relationships for the AMPA-type non-NMDA receptor by Ohmori, J, Sakamoto, S, Kubota, H, Shimizu-Sasamata, M, Okada, M, Kawasaki, S, Hidaka, K, Togami, J, Furuya, T, Murase, K

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YM90K: pharmacological characterization as a selective and potent alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor antagonist by Shimizu-Sasamata, M, Kawasaki-Yatsugi, S, Okada, M, Sakamoto, S, Yatsugi, S, Togami, J, Hatanaka, K, Ohmori, J, Koshiya, K, Usuda, S, Murase, K

“…We investigated the pharmacological properties and neuroprotective actions of a novel alpha-amino-3-hydroxy-5-methylisoxazole-y-propionate (AMPA)/kainate…”
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266 MIRABEGRON (YM178), A NOVEL ß3-ADRENOCEPTOR (AR) AGONIST, INCREASED FUNCTIONAL BLADDER CAPACITY AND DECREASED MICTURITION FREQUENCY IN CONSCIOUS WATER-LOADED CYNOMOLGUS MONKEYS by Someva, A, Ukai, M, Yanai, H, Watanabe, M, Ohtake, A, Ueshima, K, Suzuki, M, Sato, S, Sasamata, M

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Inhibition of Interleukin 1β Converting Enzyme Family Proteases Reduces Ischemic and Excitotoxic Neuronal Damage by Hara, Hideaki, Friedlander, Robert M., Gagliardini, Valeria, Ayata, Cenk, Fink, Klaus, Huang, Zhihong, Shimizu-Sasamata, Masao, Yuan, Junying, Moskowitz, Michael A.

“…The interleukin 1β converting enzyme (ICE) family plays a pivotal role in programmed cell death and has been implicated in stroke and neurodegenerative…”
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In vitro and in vivo tissue selectivity profile of solifenacin succinate (YM905) for urinary bladder over salivary gland in rats by OHTAKE, Akiyoshi, UKAI, Masashi, HATANAKA, Toshiki, KOBAYASHI, Seiji, IKEDA, Ken, SATO, Shuichi, MIYATA, Keiji, SASAMATA, Masao

“…Solifenacin succinate [YM905; (+)-(1S,3'R)-quinuclidin-3'-yl 1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate monosuccinate] is a new muscarinic receptor…”
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Impaired neurotransmitter release and elevated threshold for cortical spreading depression in mice with mutations in the α1A subunit of P/Q type calcium channels by Ayata, C., Shimizu-Sasamata, M., Lo, E.H., Noebels, J.L., Moskowitz, M.A.

“…The P/Q type voltage-gated Ca 2+ channels are involved in membrane excitability and Ca 2+-dependent neurotransmitter release within the CNS. Mutations in the…”
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Agonist diversity in 5-HT2c receptor-mediated weight control in rats by HAYASHI, Aska, SUZUKI, Masanori, SASAMATA, Masao, MIYATA, Keiji

“…Food intake and energy expenditure are the two main determinants of body weight. Given that 5-HT(2C) receptor agonists are reported to have effects on both…”
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