Search Results - "Sasaki, Y F"

Report of the IWGT working group on strategies and interpretation of regulatory in vivo tests I. Increases in micronucleated bone marrow cells in rodents that do not indicate genotoxic hazards by TWEATS, D. J, BLAKEY, D, TICE, R, HEFLICH, R. H, JACOBS, A, JACOBSEN, S. D, MORITA, T, NOHMI, T, O'DONOVAN, M. R, SASAKI, Y. F, SOFUNI, T

“…In vivo genotoxicity tests play a pivotal role in genotoxicity testing batteries. They are used both to determine if potential genotoxicity observed in vitro…”
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Single cell gel/comet assay: Guidelines for in vitro and in vivo genetic toxicology testing by Tice, R. R., Agurell, E., Anderson, D., Burlinson, B., Hartmann, A., Kobayashi, H., Miyamae, Y., Rojas, E., Ryu, J.‐C., Sasaki, Y. F.

“…Atthe International Workshop on Genotoxicity Test Procedures (IWGTP) held in Washington, DC, March 25–26, 1999, an expert panel met to develop guidelines for…”
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Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A by Lipton, Stuart A, Nakanishi, Nobuki, Das, Saumya, Sasaki, Yasnory F, Rothe, Thomas, Premkumar, Louis S, Takasu, Mari, Crandall, James E, Dikkes, Pieter, Conner, David A, Rayudu, Posina V, Cheung, Wing, Chen, H.-S. Vincent

“…The NMDA (N -methyl-D-aspartate) subclass of glutamate receptor is essential for the synaptic plasticity thought to underlie learning and memory and for…”
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Single cell gel/comet assay: Guidelines for in vitro and in vivo genetic toxicology testing by Tice, R. R., Agurell, E., Anderson, D., Burlinson, B., Hartmann, A., Kobayashi, H., Miyamae, Y., Rojas, E., Ryu, J.-C., Sasaki, Y. F.

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Report of the IWGT working group on strategy/interpretation for regulatory in vivo tests II. Identification of in vivo-only positive compounds in the bone marrow micronucleus test by TWEATS, D. J, BLAKEY, D, TICE, R, HEFLICH, R. H, JACOBS, A, JACOBSEN, S. D, MORITA, T, NOHMI, T, O'DONOVAN, M. R, SASAKI, Y. F, SOFUNI, T

“…A survey conducted as part of an International Workshop on Genotoxicity Testing (IWGT) has identified a number of compounds that appear to be more readily…”
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Evaluation of a tissue homogenization technique that isolates nuclei for the in vivo single cell gel electrophoresis (comet) assay: a collaborative study by five laboratories by Miyamae, Youichi, Yamamoto, Mika, Sasaki, Yu.F, Kobayashi, Hiroshi, Igarashi-Soga, Miyuki, Shimoi, Kayoko, Hayashi, Makoto

“…We evaluated a tissue homogenization technique that isolates nuclei for use in the in vivo comet assay. Five laboratories independently tested the technique…”
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The comet assay with 8 mouse organs: results with 39 currently used food additives by Sasaki, Yu F, Kawaguchi, Satomi, Kamaya, Asako, Ohshita, Miyuki, Kabasawa, Kazumi, Iwama, Kayoko, Taniguchi, Kazuyuki, Tsuda, Shuji

“…We determined the genotoxicity of 39 chemicals currently in use as food additives. They fell into six categories—dyes, color fixatives and preservatives,…”
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The alkaline single cell electrophoresis assay with eight mouse organs: results with 22 mono-functional alkylating agents (including 9 dialkyl N-nitrosoamines) and 10 DNA crosslinkers by Tsuda, Shuji, Matsusaka, Naonori, Madarame, Hiroo, Miyamae, Youichi, Ishida, Kumiko, Satoh, Mana, Sekihashi, Kaoru, Sasaki, Yu F

“…The genotoxicity of 22 mono-functional alkylating agents (including 9 dialkyl N-nitrosoamines) and 10 DNA crosslinkers selected from IARC (International Agency…”
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The alkaline single cell gel electrophoresis assay with mouse multiple organs: results with 30 aromatic amines evaluated by the IARC and U.S. NTP by Sasaki, Yu F, Fujikawa, Keiko, Ishida, Kumiko, Kawamura, Noriko, Nishikawa, Yukiko, Ohta, Shigenori, Satoh, Mana, Madarame, Hiroo, Ueno, Shunji, Susa, Nobuyuki, Matsusaka, Naonori, Tsuda, Shuji

“…The genotoxicity of 30 aromatic amines selected from IARC (International Agency for Research on Cancer) groups 1, 2A, 2B and 3 and from the U.S. NTP (National…”
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The comet assay in eight mouse organs: results with 24 azo compounds by Tsuda, Shuji, Matsusaka, Naonori, Madarame, Hiroo, Ueno, Shunji, Susa, Nobuyuki, Ishida, Kumiko, Kawamura, Noriko, Sekihashi, Kaoru, Sasaki, Yu F

“…The genotoxicity of 24 azo compounds selected from IARC (International Agency for Research on Cancer) groups 2A, 2B, and 3 were determined by the comet…”
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Synchronized Oscillatory Discharges of Mitral/Tufted Cells With Different Molecular Receptive Ranges in the Rabbit Olfactory Bulb by Kashiwadani, Hideki, Sasaki, Yasnory F, Uchida, Naoshige, Mori, Kensaku

“…  1 Laboratory for Neuronal Recognition Molecules, Brain Science Institute, The Institute of Physical and Chemical Research, 2-1 Hirosawa, Wako, Saitama…”
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Detection of nivalenol genotoxicity in cultured cells and multiple mouse organs by the alkaline single-cell gel electrophoresis assay by Tsuda, Shuji, Kosaka, Yoko, Murakami, Makiko, Matsuo, Hiroaki, Matsusaka, Naonori, Taniguchi, Kazuyuki, Sasaki, Yu F.

“…We tested the genotoxicity of nivalenol (NIV), a potent toxic trichothecene from Fusarium nivale, in cultured CHO cells and in several mouse organs and tissues…”
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Detection of in vivo genotoxicity of haloalkanes and haloalkenes carcinogenic to rodents by the alkaline single cell gel electrophoresis (comet) assay in multiple mouse organs by Sasaki, Yu F, Saga, Ayako, Akasaka, Makiko, Ishibashi, Satoko, Yoshida, Kumiko, Su, Ying Quan, Matsusaka, Naonori, Tsuda, Shuji

“…The micronucleus test is widely used to assess in vivo clastogenicity because of its convenience, but it is not appropriate for some carcinogenic chemical…”
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DNA damage induced by red food dyes orally administered to pregnant and male mice by Tsuda, S, Murakami, M, Matsusaka, N, Kano, K, Taniguchi, K, Sasaki, Y F

“…We determined the genotoxicity of synthetic red tar dyes currently used as food color additives in many countries, including JAPAN: For the preliminary…”
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In vivo genotoxicity of heterocyclic amines detected by a modified alkaline single cell gel electrophoresis assay in a multiple organ study in the mouse by Sasaki, Yu F, Saga, Ayako, Akasaka, Makiko, Nishidate, Emi, Watanabe-Akanuma, Mie, Ohta, Toshihiro, Matsusaka, Naonori, Tsuda, Shuji

“…We used a modification of the alkaline single cell gel electrophoresis (SCG) (Comet) assay to test the in vivo genotoxicity of 6 heterocyclic amines, Trp-P-1…”
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Characterization and Comparison of the NR3A Subunit of the NMDA Receptor in Recombinant Systems and Primary Cortical Neurons by Sasaki, Yasnory F, Rothe, Thomas, Premkumar, Louis S, Das, Saumya, Cui, Jiankun, Talantova, Maria V, Wong, Hon-Kit, Gong, Xiandi, Chan, Shing Fai, Zhang, Dongxian, Nakanishi, Nobuki, Sucher, Nikolaus J, Lipton, Stuart A

“…  1 Center for Neuroscience and Aging, The Burnham Institute, La Jolla, California 92037;   2 Department of Neurobiology and   3 Program in…”
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Detection of pyrimethamine-induced DNA damage in mouse embryo and maternal organs by the modified alkaline single cell gel electrophoresis assay by Tsuda, Shuji, Kosaka, Yoko, Matsusaka, Naonori, Sasaki, Yu F

“…We studied the embryonic and maternal genotoxicity of pyrimethamine (PYR), a potent teratogen and folate antagonist, using alkaline single cell gel…”
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Genotoxic potential of quinolone antimicrobials in the in vitro comet assay and micronucleus test by Itoh, Tadashi, Mitsumori, Kunitoshi, Kawaguchi, Satomi, Sasaki, Yu F.

“…The purpose of this study was to examine the genotoxicity of quinolone antimicrobials. We investigated the genotoxic potential of eight quinolones, namely…”
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Colon-specific genotoxicity of heterocyclic amines detected by the modified alkaline single cell gel electrophoresis assay of multiple mouse organs by Sasaki, Yu F., Saga, Ayako, Yoshida, Kumiko, Su, Ying Quan, Ohta, Toshihiro, Matsusaka, Naonori, Tsuda, Shuji

“…The in vivo genotoxicity of five heterocyclic amines—Trp-P-2 (13 mg/kg), IQ (13 mg/kg), MeIQ (13 mg/kg), MeIQx (13 mg/kg), and PhIP (40 mg/kg)—in the mucosa of…”
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Comparative investigation of multiple organs of mice and rats in the comet assay by Sekihashi, Kaoru, Yamamoto, Ayumu, Matsumura, Yukie, Ueno, Shunji, Watanabe-Akanuma, Mie, Kassie, Fekadu, Knasmüller, Siegfried, Tsuda, Shuji, Sasaki, Yu F

“…Mice and/or rats are usually used to detect chemical carcinogenicity and it has been known that there are species differences in carcinogenicity. To know…”
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