Search Results - "Sasaki, Takaaki"

The biology and treatment of EML4-ALK non-small cell lung cancer by Sasaki, Takaaki, Rodig, Scott J, Chirieac, Lucian R, Jänne, Pasi A

“…Abstract The fusion between echinoderm microtubule-associated protein-like 4 (EML4) and anaplastic lymphoma kinase (ALK) has recently been identified in a…”
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New Strategies for Treatment of ALK-Rearranged Non―Small Cell Lung Cancers by SASAKI, Takaaki, JÄNNE, Pasi A

“…The identification of oncogenic alterations in subsets of patients with non-small cell lung cancer (NSCLC) is transforming clinical care. Genomic…”
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Immunotherapy-related hepatitis and thrombocytopaenia induced by the very low dose of only 90 mg of atezolizumab by Tsukita, Yoko, Miyauchi, Eisaku, Fukudo, Masahide, Sasaki, Takaaki, Ichinose, Masakazu

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A Novel ALK Secondary Mutation and EGFR Signaling Cause Resistance to ALK Kinase Inhibitors by SASAKI, Takaaki, KOIVUNEN, Jussi, CAPELLETTI, Marzia, SHIMAMURA, Takeshi, ERCAN, Dalia, STUMPFOVA, Magda, YUN XIAO, WEREMOWICZ, Stanislawa, BUTANEY, Mohit, HEON, Stephanie, WILNER, Keith, CHRISTENSEN, James G, OGINO, Atsuko, ECK, Michel J, WONG, Kwok-Kin, LINDEMAN, Neal, GRAY, Nathanael S, RODIG, Scott J, JÄNNE, Pasi A, YANAGITA, Masahiko, NIKIFOROW, Sarah, ZHENG, Wei, LATHAN, Christopher, PAUL MARCOUX, J, JINYAN DU, OKUDA, Katsuhiro

“…Anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKI), including crizotinib, are effective treatments in preclinical models and in cancer patients…”
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First-line osimertinib in elderly patients with epidermal growth factor receptor-mutated advanced non-small cell lung cancer: a retrospective multicenter study (HOT2002) by Yamamoto, Gaku, Asahina, Hajime, Honjo, Osamu, Sumi, Toshiyuki, Nakamura, Atsushi, Ito, Kenichiro, Kikuchi, Hajime, Hommura, Fumihiro, Honda, Ryoichi, Yokoo, Keiki, Fujita, Yuka, Oizumi, Satoshi, Morita, Ryo, Ikezawa, Yasuyuki, Tanaka, Hisashi, Kimura, Nozomu, Sasaki, Takaaki, Sukoh, Noriaki, Takashina, Taichi, Harada, Toshiyuki, Dosaka-Akita, Hirotoshi, Isobe, Hiroshi

“…Osimertinib is a standard of care therapy for previously untreated epidermal growth factor receptor mutation-positive non-small cell lung cancer. However,…”
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The neuroblastoma-associated F1174L ALK mutation causes resistance to an ALK kinase inhibitor in ALK-translocated cancers by Sasaki, Takaaki, Okuda, Katsuhiro, Zheng, Wei, Butrynski, James, Capelletti, Marzia, Wang, Liping, Gray, Nathanael S, Wilner, Keith, Christensen, James G, Demetri, George, Shapiro, Geoffrey I, Rodig, Scott J, Eck, Michael J, Jänne, Pasi A

“…The ALK kinase inhibitor crizotinib (PF-02341066) is clinically effective in patients with ALK-translocated cancers, but its efficacy will ultimately be…”
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Real-World Efficacy of Ensitrelvir in Hospitalized Patients With COVID-19 in Japan: A Retrospective Observational Study by Yoshida, Ryohei, Sasaki, Takaaki, Ohsaki, Yoshinobu

“…The coronavirus disease 2019 (COVID-19) pandemic necessitates continuously evaluating antiviral treatments, especially for high-risk groups, including older…”
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A stealth antigen SPESP1, which is epigenetically silenced in tumors, is a suitable target for cancer immunotherapy by Kosaka, Akemi, Yajima, Yuki, Hatayama, Mayumi, Ikuta, Katsuya, Sasaki, Takaaki, Hirai, Noriko, Yasuda, Syunsuke, Nagata, Marino, Hayashi, Ryusuke, Harabuchi, Shohei, Ohara, Kenzo, Ohara, Mizuho, Kumai, Takumi, Ishibashi, Kei, Hirata‐Nozaki, Yui, Nagato, Toshihiro, Oikawa, Kensuke, Harabuchi, Yasuaki, Celis, Esteban, Okumura, Toshikatsu, Ohsaki, Yoshinobu, Kobayashi, Hiroya, Ohkuri, Takayuki

“…Recent studies have revealed that tumor cells decrease their immunogenicity by epigenetically repressing the expression of highly immunogenic antigens to…”
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Neuromyelitis optica spectrum disorder secondary to treatment with anti-PD-1 antibody nivolumab: the first report by Narumi, Yoshitsugu, Yoshida, Ryohei, Minami, Yoshinori, Yamamoto, Yasushi, Takeguchi, Shiori, Kano, Kohei, Takahashi, Kae, Saito, Tsukasa, Sawada, Jun, Terui, Hiroya, Katayama, Takayuki, Sasaki, Takaaki, Ohsaki, Yoshinobu

“…Immune checkpoint blockade is developed as standard treatment for non-small cell lung cancer. However immune-related adverse events (irAE) have still unknown…”
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Clinical trial of photodynamic therapy for peripheral-type lung cancers using a new laser device in a pilot study by Usuda, Jitsuo, Inoue, Tatsuya, Tsuchida, Takaaki, Ohtani, Keishi, Maehara, Sachio, Ikeda, Norihiko, Ohsaki, Yoshinobu, Sasaki, Takaaki, Oka, Kiyoshi

“…•We developed a new laser probe, which allows accurate laser irradiation of a cancer lesion with simultaneous visualization of the lesion.•We attempted a new…”
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Monitoring epidermal growth factor receptor C797S mutation in Japanese non–small cell lung cancer patients with serial cell‐free DNA evaluation using digital droplet PCR by Ariyasu, Ryo, Uchibori, Ken, Sasaki, Takaaki, Tsukahara, Mika, Kiyotani, Kazuma, Yoshida, Ryohei, Ono, Yusuke, Kitazono, Satoru, Ninomiya, Hironori, Ishikawa, Yuichi, Mizukami, Yusuke, Yanagitani, Noriko, Fujita, Naoya, Nishio, Makoto, Katayama, Ryohei

“…Osimertinib is a third‐generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR‐TKI) that is effective in treating both naïve and…”
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Highly sensitive detection of ALK resistance mutations in plasma using droplet digital PCR by Yoshida, Ryohei, Sasaki, Takaaki, Umekage, Yasuhiro, Tanno, Sachie, Ono, Yusuke, Ogata, Munehiko, Chiba, Shinichi, Mizukami, Yusuke, Ohsaki, Yoshinobu

“…On-target resistance mechanisms found in one-third of patients receiving anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) are secondary ALK…”
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Inhibition of ALK, PI3K/MEK, and HSP90 in Murine Lung Adenocarcinoma Induced by EML4-ALK Fusion Oncogene by ZHAO CHEN, SASAKI, Takaaki, HYUN JOO LEE, RODIG, Scott J, BORGMAN, Christa, PARK, Seung-Il, HYEONG RYUL KIM, PADERA, Robert, MARTO, Jarrod A, GRAY, Nathanael S, KUNG, Andrew L, SHAPIRO, Geoffrey I, XIAOHONG TAN, JÄNNE, Pasi A, WONG, Kwok-Kin, CARRETERO, Julian, SHIMAMURA, Takeshi, DANAN LI, CHUNXIAO XU, YUCHUAN WANG, ADELMANT, Guillaume O, CAPELLETTI, Marzia

“…Genetic rearrangements of the anaplastic lymphoma kinase (ALK) kinase occur in 3% to 13% of non-small cell lung cancer patients and rarely coexist with KRASor…”
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High-resolution separation of neodymium and dysprosium ions utilizing extractant-impregnated graft-type particles by Uchiyama, Shoichiro, Sasaki, Takaaki, Ishihara, Ryo, Fujiwara, Kunio, Sugo, Takanobu, Umeno, Daisuke, Saito, Kyoichi

“…•Bis(2-ethylhexyl) phosphate-impregnated graft-type particle as a column filler was prepared.•Non-porous and polymer-brush-rich structure minimized diffusional…”
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A Randomized Phase 2 Study of 5-Aminolevulinic Acid Hydrochloride and Sodium Ferrous Citrate for the Prevention of Nephrotoxicity Induced by Cisplatin-Based Chemotherapy of Lung Cancer by Kawamura, Kodai, Matsushima, Hidekazu, Sakai, Hiroshi, Iwashima, Akira, Nakamura, Sukeyuki, Kojima, Tohru, Sasaki, Shinichi, Shigenaga, Takehiko, Natsume, Ichiro, Sasaki, Takaaki, Ohsaki, Yoshinobu, Iwanaga, Kentaro, Nishi, Koichi, Mitsuishi, Yoichiro, Taniguchi, Hirokazu, Sato, Kazuhiro, Yamauchi, Mitsugu, Nakajima, Motowo, Takahashi, Kazuhisa

“…Cisplatin-based chemotherapy was established in the 1980s, and it has been improved by the development of a short hydration protocol in lung cancer therapy…”
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Activation of Src signaling mediates acquired resistance to ALK inhibition in lung cancer by Yoshida, Ryohei, Sasaki, Takaaki, Minami, Yoshinori, Hibino, Yukiko, Okumura, Shunsuke, Sado, Masatoshi, Miyokawa, Naoyuki, Hayashi, Satoshi, Kitada, Masahiro, Ohsaki, Yoshinobu

“…Anaplastic lymphoma kinase (ALK) fusion oncogenes occur in approximately 3-5% of non-small cell lung cancer (NSCLC) cases. Various ALK inhibitors are in…”
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Monomerization of ALK Fusion Proteins as a Therapeutic Strategy in ALK -Rearranged Non-small Cell Lung Cancers by Hirai, Noriko, Sasaki, Takaaki, Okumura, Shunsuke, Minami, Yoshinori, Chiba, Shinichi, Ohsaki, Yoshinobu

“…Oncogenic echinoderm microtubule-associated protein-like 4 anaplastic lymphoma kinase ( ) (EML4-ALK) fusion proteins found in non-small cell lung cancers…”
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Case Report: Case series: association between blood concentration and side effects of sotorasib by Shigaki, Ryota, Yoshida, Ryohei, Yagita, Akari, Nagasue, Kazunori, Naraoka, Taeka, Nitanai, Kiichi, Yanada, Hiraku, Tenma, Toshiyuki, Kida, Ryotaro, Umekage, Yasuhiro, Mori, Chie, Minami, Yoshinori, Sato, Hideki, Iwayama, Kuninori, Hashino, Yasuhisa, Fukudo, Masahide, Sasaki, Takaaki

“…Introduction Sotorasib is a crucial therapeutic agent for patients with non-small cell lung cancer (NSCLC) harboring the KRAS p.G12C mutation. Despite its…”
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Evaluation of a Quantitative Serological Assay for Diagnosing Chronic Pulmonary Aspergillosis by Fujiuchi, Satoru, Fujita, Yuka, Suzuki, Hokuto, Doushita, Kazushi, Kuroda, Hikaru, Takahashi, Masaaki, Yamazaki, Yasuhiro, Tsuji, Tadakatsu, Fujikane, Toshiaki, Osanai, Shinobu, Sasaki, Takaaki, Ohsaki, Yoshinobu

“…The purpose of this study was to evaluate the clinical utility of a quantitative Aspergillus IgG assay for diagnosing chronic pulmonary aspergillosis. We…”
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Monitoring SARS-CoV-2 Viral Load and CD4+ T-cell Count After ART in a Patient Diagnosed With AIDS Following SARS-CoV-2 Infection: A Case Report by Umekage, Yasuhiro, Hatayama, Mayumi, Yagita, Akari, Nitanai, Kiichi, Yanada, Hiraku, Shigaki, Ryota, Minami, Yoshinori, Sasaki, Takaaki

“…We describe the case of a 36-year-old man diagnosed with human immunodeficiency virus (HIV) following prolonged severe acute respiratory syndrome coronavirus 2…”
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