Search Results - "Sasaki, Shoji"

General considerations in ocular toxicity risk assessment from the toxicologists’ viewpoints by Onodera, Hiroshi, Sasaki, Shoji, Otake, Seiji, Tomohiro, Masayuki, Shibuya, Kazumoto, Nomura, Mamoru

“…Humans commonly obtain approximately 80% of external information from vision. Since loss of vision markedly decreases quality of life, risk assessments for…”
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Characteristics of structures and lesions of the eye in laboratory animals used in toxicity studies by Shibuya, Kazumoto, Tomohiro, Masayuki, Sasaki, Shoji, Otake, Seiji

“…Histopathology of the eye is an essential part of ocular toxicity evaluation. There are structural variations of the eye among several laboratory animals…”
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Electroretinography (ERG) -Related Guidelines by SASAKI, Shoji

“…The International Society for Clinical Electrophysiology of Vision (ISCEV) published the first standardized basic protocol in 1989 so that comparable…”
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Functions of the Two Glutamate Transporters GLAST and GLT-1 in the Retina by Harada, Takayuki, Harada, Chikako, Watanabe, Masahiko, Inoue, Yoshiro, Sakagawa, Takashi, Nakayama, Naoki, Sasaki, Shoji, Okuyama, Shigeru, Watase, Kei, Wada, Keiji, Tanaka, Kohichi

“…In the retina, the glutamate transporter GLAST is expressed in Muller cells, whereas the glutamate transporter GLT-1 is found only in cones and various types…”
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Scientific Viewpoints in Ocular Toxicity Assessment: Departure from Conventional Practicearch by ONODERA, Hiroshi, SASAKI, Shoji, OTAKE, Seiji, TOMOHIRO, Masayuki, SHIBUYA, Kazumoto, NOMURA, Mamoru

“…Humans commonly obtain approximately 80% of external information from vision. Since quality of life markedly decreases with loss of vision, risk assessment for…”
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P-VECP can reveal visual toxicity in pigmented rats of repeated doses of ethambutol by Sasaki, Shoji, Yagi, Kumiko, Miyata, Hiroto, Nakamura, Isamu, Iwaki, Yoshinobu, Kimura, Masaaki

“…We determined if pattern visually evoked cortical potentials (P-VECPs) in pigmented rats would reveal visual toxicity induced by a drug even when in cases of…”
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Visually evoked cortical potentials obtained using checker patterns can detect ethambutol-induced visual toxicity in albino rats by Sasaki, Shoji, Yagi, Kumiko, Nakamura, Isamu, Iwaki, Yoshinobu, Kimura, Masaaki

“…We determined whether visually evoked cortical potentials obtained using checker patterns (P-VECPs) and albino rats would reveal visual damage induced by…”
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Toxicologic Pathology Forum: Current Status on the Use of Animal Models of Human Disease in the Pharmaceutical Industry in Japan in Nonclinical Safety Assessment–Opinion Paper by Tomohiro, Masayuki, Okabe, Takeshi, Kimura, Yasushi, Kinoshita, Kiyoshi, Maeda, Mitsunori, Mitobe, Yuko, Motoyama, Keiko, Yonezawa, Riichiro, Sasaki, Shoji, Fujiwara, Michio, Watanabe, Kazuto

“…In nonclinical safety studies for new drug development, healthy animals have been commonly used. However, in some cases, the use of animal models of human…”
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眼毒性リスク評価のサイエンス：お作法からの脱却 by 小野寺, 博志, 佐々木, 正治, 大竹, 誠司, 友廣, 雅之, 渋谷, 一元, 野村, 護

“…ヒトは外部情報の約80%を視覚から得ているといわれ、視覚を喪失した場合、QOLは大きく低下する。そのため視覚毒性のリスク評価の重要性は極めて高い。しかし、医薬品を申請するための安全性を担保する非臨床毒性試験ではICH…”
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Electroretinography (ERG) に関連したガイドライン by 佐々木, 正治

“…国際臨床視覚電気生理学会（International Society of Clinical Electrophysiology of Vision; ISCEV）が網膜電図（Electroretinography;…”
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Isozymes of isocitrate dehydrogenase from an obligately psychrophilic bacterium, Vibrio sp. strain ABE-1: purification, and modulation of activities by growth conditions by Ishii, A, Ochiai, T, Imagawa, S, Fukunaga, N, Sasaki, S, Minowa, O, Mizuno, Y, Shiokawa, H

“…Each of the two isozymes, which are different in thermostability and quaternary structure, of isocitrate dehydrogenase (NADP+) [IDH: EC 1.1.1.42] was purified…”
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Full-field ERGs obtained using a contact lens electrode with built-in high intensity white light-emitting diodes in beagle dogs can be applied to toxicological assessments by Sasaki, Shoji, Yamashita, Haruhiro, Yagi, Kumiko, Iwaki, Yoshinobu, Kimura, Masaaki

“…We investigated full-field ERGs in beagle dogs using a contact lens electrode with built-in LED. Experiment 1 was performed to determine the appropriate…”
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AEROBIC SYNTHESIS OF UNSATURATED FATTY ACIDS IN A PSYCHROTROPHIC BACTERIUM, PSEUDOMONAS SP. STRAIN E-3, HAVING TWO MECHANISMS FOR UNSATURATED FATTY ACID SYNTHESIS by WADA, MASATO, FUKUNAGA, NORIYUKI, SASAKI, SHOJI

“…3-Decynoyl N-acetylcysteamine (DNAC), a specific inhibitor of the anaerobic pathway for bacterial unsaturated fatty acid synthesis, completely inhibited the…”
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Membrane-bound ATPase of a psychrophilic marine bacterium, Vibrio sp. Strain ABE-1 by Harashima, A. (Hokkaido Univ., Sapporo (Japan). Faculty of Science), Takada, Y, Fukunaga, N, Sasaki, S

“…Several properties of ATPase bound to the inner membrane of a psychrophilic marine bacterium Vibrio sp. strain ABE-1 were examined. The membrane-bound ATPase…”
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TWO GROUPS OF PHOSPHATIDYLETHANOLAMINE IN VIBRIO SP. STRAIN ABE-1 SEPARATED BY SILICA GEL THIN-LAYER CHROMATOGRAPHY by OKUYAMA, HIDETOSHI, SASAKI, SHOJI

“…We analyzed a previously unknown phospholipid (PL-2) in the psychrophilic bacterium, Vibrio ABE-1 . In thin-layer chromatography, it moved close to…”
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The estrogen receptor locus is associated with a major gene influencing litter size in pigs by Rothschild, M. (Iowa State University, Ames, IA.), Jacobsen, C, Vaske, D, Tuggle, C, Wang, L.H, Short, T, Eckardt, G, Sasaki, S, Vincent, A, McLaren, D

“…Identification of individual major genes affecting quantitative traits in livestock species has been limited to date. By using a candidate gene approach and a…”
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COUPLING SITE OF THE RESPIRATION-DEPENDENT SODIUM PUMP IN A PSYCHROPHILIC BACTERIUM, VIBRIO SP. STRAIN ABE-1 by TAKADA, YASUHIRO, FUKUNAGA, NORIYUKI, SASAKI, SHOJI

“…The coupling site of a respiration-dependent primary Na+ pump to the respiratory chain was studied in a psychrophilic bacterium, Vibrio sp. strain ABE-1…”
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Purification and some properties of two NADP+-specific isocitrate dehydrogenases from an obligately psychrophilic marine bacterium, Vibrio sp., strain ABE-1 by Ochiai, T, Fukunaga, N, Sasaki, S

“…Two isozymes of NADP+-specific isocitrate dehydrogenase [ICDH; EC 1.1.1.42] were confirmed to be present in an obligately psychrophilic marine bacterium,…”
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HOMEOVISCOUS ADAPTATION IN A PSYCHROPHILIC BACTERIUM, VIBRIO SP. STRAIN ABE-1 by OKUYAMA, HIDETOSHI, FUKUNAGA, NORIYUKI, SASAKI, SHOJI

“…The phase separation of total phospholipids and four individual phospholipids from a psychrophilic bacterium, Vibrio sp. strain ABE-1 (Vibrio ABE-1), was…”
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TWO STRUCTURALLY DIFFERENT NADP-SPECIFIC ISOCITRATE DEHYDROGENASES IN AN OBLIGATELY PSYCHROPHILIC BACTERIUM, VIBRIO SP. STRAIN ABE-1 by OCHIAI, TOSHIRO, FUKUNAGA, NORIYUKI, SASAKI, SHOJI

“…Two isozymes of NADP-specific isocitrate dehydrogenase (EC 1.1.1.42) were purified from the obligately psychrophilic marine bacterium Vibrio sp, strain ABE-1…”
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