Search Results - "Sasaki, Nobuo"

Creating a Future in which the Intestinal Environment Can be Designed ad arbitrium by Sasaki, Nobuo

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Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer by Drost, Jarno, van Boxtel, Ruben, Blokzijl, Francis, Mizutani, Tomohiro, Sasaki, Nobuo, Sasselli, Valentina, de Ligt, Joep, Behjati, Sam, Grolleman, Judith E., van Wezel, Tom, Nik-Zainal, Serena, Kuiper, Roland P., Cuppen, Edwin, Clevers, Hans

“…Mutational processes underlie cancer initiation and progression. Signatures of these processes in cancer genomes may explain cancer etiology and could hold…”
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Somatic inflammatory gene mutations in human ulcerative colitis epithelium by Nanki, Kosaku, Fujii, Masayuki, Shimokawa, Mariko, Matano, Mami, Nishikori, Shingo, Date, Shoichi, Takano, Ai, Toshimitsu, Kohta, Ohta, Yuki, Takahashi, Sirirat, Sugimoto, Shinya, Ishimaru, Kazuhiro, Kawasaki, Kenta, Nagai, Yoko, Ishii, Ryota, Yoshida, Kosuke, Sasaki, Nobuo, Hibi, Toshifumi, Ishihara, Soichiro, Kanai, Takanori, Sato, Toshiro

“…With ageing, normal human tissues experience an expansion of somatic clones that carry cancer mutations 1 – 7 . However, whether such clonal expansion exists…”
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Development of a Scalable Coculture System for Gut Anaerobes and Human Colon Epithelium by Sasaki, Nobuo, Miyamoto, Kentaro, Maslowski, Kendle M., Ohno, Hiroshi, Kanai, Takanori, Sato, Toshiro

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Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients by Schwank, Gerald, Koo, Bon-Kyoung, Sasselli, Valentina, Dekkers, Johanna F., Heo, Inha, Demircan, Turan, Sasaki, Nobuo, Boymans, Sander, Cuppen, Edwin, van der Ent, Cornelis K., Nieuwenhuis, Edward E.S., Beekman, Jeffrey M., Clevers, Hans

“…Single murine and human intestinal stem cells can be expanded in culture over long time periods as genetically and phenotypically stable epithelial organoids…”
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In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration by Huch, Meritxell, Dorrell, Craig, Boj, Sylvia F., van Es, Johan H., Li, Vivian S. W., van de Wetering, Marc, Sato, Toshiro, Hamer, Karien, Sasaki, Nobuo, Finegold, Milton J., Haft, Annelise, Vries, Robert G., Grompe, Markus, Clevers, Hans

“…A mouse model of liver damage has identified a population of Lrg5 + liver stem cells that can generate hepatoctyes and bile ducts in vivo. Wake-up call for…”
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Automated brightfield morphometry of 3D organoid populations by OrganoSeg by Borten, Michael A., Bajikar, Sameer S., Sasaki, Nobuo, Clevers, Hans, Janes, Kevin A.

“…Spheroid and organoid cultures are powerful in vitro models for biology, but size and shape diversity within the culture is largely ignored. To streamline…”
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Extension of the {100}-Oriented Grain-Boundary Free Si Thin Film Grown by a Continuous-Wave Laser Lateral Crystallization by Arif, Muhammad, Sasaki, Nobuo, Ishikawa, Yasuaki, Uraoka, Yukiharu

“…•Stable and huge grain growth of Si thin films.•Orientations of {100} in the surface normal and scan directions.•Length of more than 3000 μm.•Width of 120-150…”
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Continuous-Wave Laser Lateral Crystallization of A-Si Thin Films on Polyimide Using a Heatsink Layer Embedded in the Buffer SiO2 by Sasaki, Nobuo, Arif, Muhammad, Uraoka, Yukiharu, Gotoh, Jun, Sugimoto, Shigeto

“…Continuous-wave laser crystallization of amorphous Si (a-Si) thin films on a polyimide (PI)-coated glass substrate is studied by using a single scan of a…”
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Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver by Huch, Meritxell, Gehart, Helmuth, van Boxtel, Ruben, Hamer, Karien, Blokzijl, Francis, Verstegen, Monique M.A., Ellis, Ewa, van Wenum, Martien, Fuchs, Sabine A., de Ligt, Joep, van de Wetering, Marc, Sasaki, Nobuo, Boers, Susanne J., Kemperman, Hans, de Jonge, Jeroen, Ijzermans, Jan N.M., Nieuwenhuis, Edward E.S., Hoekstra, Ruurdtje, Strom, Stephen, Vries, Robert R.G., van der Laan, Luc J.W., Cuppen, Edwin, Clevers, Hans

“…Despite the enormous replication potential of the human liver, there are currently no culture systems available that sustain hepatocyte replication and/or…”
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Dll1+ secretory progenitor cells revert to stem cells upon crypt damage by van Es, Johan H., Sato, Toshiro, van de Wetering, Marc, Lyubimova, Anna, Yee Nee, Annie Ng, Gregorieff, Alex, Sasaki, Nobuo, Zeinstra, Laura, van den Born, Maaike, Korving, Jeroen, Martens, Anton C. M., Barker, Nick, van Oudenaarden, Alexander, Clevers, Hans

“…Notch signalling in the intestinal crypt is modulated to drive commitment to the secretory fate. Clevers and colleagues find that cells expressing the Notch…”
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Association of Insulin Resistance, Plasma Glucose Level, and Serum Insulin Level With Hypertension in a Population With Different Stages of Impaired Glucose Metabolism by Sasaki, Nobuo, Ozono, Ryoji, Higashi, Yukihito, Maeda, Ryo, Kihara, Yasuki

“…Background The interrelationships among the different stages of impaired glucose metabolism, insulin resistance, and hypertension are not fully understood…”
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Adipose tissue insulin resistance predicts the incidence of hypertension: The Hiroshima Study on Glucose Metabolism and Cardiovascular Diseases by Sasaki, Nobuo, Maeda, Ryo, Ozono, Ryoji, Yoshimura, Kenichi, Nakano, Yukiko, Higashi, Yukihito

“…We investigated the association of adipose tissue insulin resistance with blood pressure and hypertension incidence, comparing it with hepatic and skeletal…”
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Reg4⁺ deep crypt secretory cells function as epithelial niche for Lgr5⁺ stem cells in colon by Sasaki, Nobuo, Sachs, Norman, Wiebrands, Kay, Ellenbroek, Saskia I. J., Fumagalli, Arianna, Lyubimova, Anna, Begthel, Harry, van den Born, Maaike, van Es, Johan H., Karthaus, Wouter R., Li, Vivian S. W., López-Iglesias, Carmen, Peters, Peter J., van Rheenen, Jacco, van Oudenaarden, Alexander, Clevers, Hans

“…Leucine-rich repeat-containing G-protein coupled receptor 5-positive (Lgr5⁺) stem cells reside at crypt bottoms of the small and large intestine. Small…”
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Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids by Bolhaqueiro, Ana C. F., Ponsioen, Bas, Bakker, Bjorn, Klaasen, Sjoerd J., Kucukkose, Emre, van Jaarsveld, Richard H., Vivié, Judith, Verlaan-Klink, Ingrid, Hami, Nizar, Spierings, Diana C. J., Sasaki, Nobuo, Dutta, Devanjali, Boj, Sylvia F., Vries, Robert G. J., Lansdorp, Peter M., van de Wetering, Marc, van Oudenaarden, Alexander, Clevers, Hans, Kranenburg, Onno, Foijer, Floris, Snippert, Hugo J. G., Kops, Geert J. P. L.

“…Chromosome segregation errors cause aneuploidy and genomic heterogeneity, which are hallmarks of cancer in humans. A persistent high frequency of these errors…”
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Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion by van Es, Johan H., Wiebrands, Kay, López-Iglesias, Carmen, van de Wetering, Marc, Zeinstra, Laura, van den Born, Maaike, Korving, Jeroen, Sasaki, Nobuo, Peters, Peter J., van Oudenaarden, Alexander, Clevers, Hans

“…Cycling intestinal Lgr5⁺ stem cells are intermingled with their terminally differentiated Paneth cell daughters at crypt bottoms. Paneth cells provide multiple…”
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Associations Between Characteristics of Obstructive Sleep Apnea and Nocturnal Blood Pressure Surge by Sasaki, Nobuo, Nagai, Michiaki, Mizuno, Hiroyuki, Kuwabara, Mitsuo, Hoshide, Satoshi, Kario, Kazuomi

“…Research suggests that oxygen desaturation and sleep stage during obstructive sleep apnea (OSA) are related to the magnitude of high blood pressure (BP) in a…”
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Association of Flow Parameters and Diameter in the Common Carotid Artery with Impaired Glucose Metabolism by Sasaki, Nobuo, Maeda, Ryo, Ozono, Ryoji, Nakano, Yukiko, Higashi, Yukihito

“…Aim: Diameter, intima–media thickness (IMT), and flow parameters, including resistance index (RI) and pulsatility index (PI), in the common carotid artery…”
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Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis by Nakamoto, Nobuhiro, Sasaki, Nobuo, Aoki, Ryo, Miyamoto, Kentaro, Suda, Wataru, Teratani, Toshiaki, Suzuki, Takahiro, Koda, Yuzo, Chu, Po-Sung, Taniki, Nobuhito, Yamaguchi, Akihiro, Kanamori, Mitsuhiro, Kamada, Nobuhiko, Hattori, Masahira, Ashida, Hiroshi, Sakamoto, Michiie, Atarashi, Koji, Narushima, Seiko, Yoshimura, Akihiko, Honda, Kenya, Sato, Toshiro, Kanai, Takanori

“…Primary sclerosing cholangitis (PSC) is a chronic inflammatory liver disease and its frequent complication with ulcerative colitis highlights the pathogenic…”
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Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells by Han, Seungmin, Fink, Juergen, Jörg, David J., Lee, Eunmin, Yum, Min Kyu, Chatzeli, Lemonia, Merker, Sebastian R., Josserand, Manon, Trendafilova, Teodora, Andersson-Rolf, Amanda, Dabrowska, Catherine, Kim, Hyunki, Naumann, Ronald, Lee, Ji-Hyun, Sasaki, Nobuo, Mort, Richard Lester, Basak, Onur, Clevers, Hans, Stange, Daniel E., Philpott, Anna, Kim, Jong Kyoung, Simons, Benjamin D., Koo, Bon-Kyoung

“…The gastric corpus epithelium is the thickest part of the gastrointestinal tract and is rapidly turned over. Several markers have been proposed for gastric…”
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