Search Results - "Sasakawa, Chihiro"

An update on the regulatory mechanisms of NLRP3 inflammasome activation by Paik, Seungwha, Kim, Jin Kyung, Silwal, Prashanta, Sasakawa, Chihiro, Jo, Eun-Kyeong

“…The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is a multiprotein complex involved in the release of mature interleukin-1β and…”
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Molecular mechanisms regulating NLRP3 inflammasome activation by Jo, Eun-Kyeong, Kim, Jin Kyung, Shin, Dong-Min, Sasakawa, Chihiro

“…Inflammasomes are multi-protein signaling complexes that trigger the activation of inflammatory caspases and the maturation of interleukin-1β. Among various…”
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Exploitation of the host ubiquitin system by human bacterial pathogens by Ashida, Hiroshi, Kim, Minsoo, Sasakawa, Chihiro

“…Key Points Ubiquitylation is a host defence system that prevents bacterial infection; however, many bacterial pathogens exploit this system using virulence…”
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Bacteria and host interactions in the gut epithelial barrier by Ashida, Hiroshi, Ogawa, Michinaga, Kim, Minsoo, Mimuro, Hitomi, Sasakawa, Chihiro

“…The gut mucosa acts as a barrier against microbial invaders, whereas resident commensal and foreign invading bacteria interact intimately with the gut…”
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Cell death and infection: a double-edged sword for host and pathogen survival by Ashida, Hiroshi, Mimuro, Hitomi, Ogawa, Michinaga, Kobayashi, Taira, Sanada, Takahito, Kim, Minsoo, Sasakawa, Chihiro

“…Host cell death is an intrinsic immune defense mechanism in response to microbial infection. However, bacterial pathogens use many strategies to manipulate the…”
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Innate lymphoid cells regulate intestinal epithelial cell glycosylation by Goto, Yoshiyuki, Obata, Takashi, Kunisawa, Jun, Sato, Shintaro, Ivanov, Ivaylo I., Lamichhane, Aayam, Takeyama, Natsumi, Kamioka, Mariko, Sakamoto, Mitsuo, Matsuki, Takahiro, Setoyama, Hiromi, Imaoka, Akemi, Uematsu, Satoshi, Akira, Shizuo, Domino, Steven E., Kulig, Paulina, Becher, Burkhard, Renauld, Jean-Christophe, Sasakawa, Chihiro, Umesaki, Yoshinori, Benno, Yoshimi, Kiyono, Hiroshi

“…Fucosylation of intestinal epithelial cells, catalyzed by fucosyltransferase 2 (Fut2), is a major glycosylation mechanism of host-microbiota symbiosis…”
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Differential Roles of Interleukin-17A and -17F in Host Defense against Mucoepithelial Bacterial Infection and Allergic Responses by Ishigame, Harumichi, Kakuta, Shigeru, Nagai, Takeshi, Kadoki, Motohiko, Nambu, Aya, Komiyama, Yutaka, Fujikado, Noriyuki, Tanahashi, Yuko, Akitsu, Aoi, Kotaki, Hayato, Sudo, Katsuko, Nakae, Susumu, Sasakawa, Chihiro, Iwakura, Yoichiro

“…Interleukin-17A (IL-17A) is a cytokine produced by T helper 17 (Th17) cells and plays important roles in the development of inflammatory diseases. Although…”
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First detection of porcine circovirus type 3 in Japan by HAYASHI, Shizuka, OHSHIMA, Yoshiyuki, FURUYA, Yoshiaki, NAGAO, Aki, OROKU, Kazuki, TSUTSUMI, Nobuyuki, SASAKAWA, Chihiro, SATO, Tetsuo

“…Porcine circovirus associated diseases (PCVAD) have multiple manifestations that have been attributed to porcine circovirus type 2 (PCV2). Recently, a novel…”
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Shigella IpaH0722 E3 ubiquitin ligase effector targets TRAF2 to inhibit PKC-NF-κB activity in invaded epithelial cells by Ashida, Hiroshi, Nakano, Hiroyasu, Sasakawa, Chihiro

“…NF-κB plays a central role in modulating innate immune responses to bacterial infections. Therefore, many bacterial pathogens deploy multiple mechanisms to…”
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Listeria monocytogenes ActA-mediated escape from autophagic recognition by Ishii, Tetsuro, Yoshikawa, Yuko, Kim, Minsoo, Nakagawa, Ichiro, Chakraborty, Trinad, Sztul, Elizabeth, Sasakawa, Chihiro, Hain, Torsten, Yoshida, Mitsutaka, Mimuro, Hitomi, Kakizuka, Akira, Ogawa, Michinaga, Fukumatsu, Makoto, Yanagawa, Toru

“…Autophagy degrades unnecessary organelles and misfolded protein aggregates, as well as cytoplasm-invading bacteria. Nevertheless, the bacteria Listeria…”
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The Shigella OspC3 Effector Inhibits Caspase-4, Antagonizes Inflammatory Cell Death, and Promotes Epithelial Infection by Kobayashi, Taira, Ogawa, Michinaga, Sanada, Takahito, Mimuro, Hitomi, Kim, Minsoo, Ashida, Hiroshi, Akakura, Reiko, Yoshida, Mitsutaka, Kawalec, Magdalena, Reichhart, Jean-Marc, Mizushima, Tsunehiro, Sasakawa, Chihiro

“…Caspase-mediated inflammatory cell death acts as an intrinsic defense mechanism against infection. Bacterial pathogens deploy countermeasures against…”
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Shigella IpaH Family Effectors as a Versatile Model for Studying Pathogenic Bacteria by Ashida, Hiroshi, Sasakawa, Chihiro

“…Shigella spp. are highly adapted human pathogens that cause bacillary dysentery (shigellosis). Via the type III secretion system (T3SS), Shigella deliver a…”
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Shigella type III secretion protein MxiI is recognized by Naip2 to induce Nlrc4 inflammasome activation independently of Pkcδ by Suzuki, Shiho, Franchi, Luigi, He, Yuan, Muñoz-Planillo, Raul, Mimuro, Hitomi, Suzuki, Toshihiko, Sasakawa, Chihiro, Núñez, Gabriel

“…Recognition of intracellular pathogenic bacteria by members of the nucleotide-binding domain and leucine-rich repeat containing (NLR) family triggers immune…”
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Epigenetic silencing of miR-210 increases the proliferation of gastric epithelium during chronic Helicobacter pylori infection by Kiga, Kotaro, Mimuro, Hitomi, Suzuki, Masato, Shinozaki-Ushiku, Aya, Kobayashi, Taira, Sanada, Takahito, Kim, Minsoo, Ogawa, Michinaga, Iwasaki, Yuka W., Kayo, Hiroyuki, Fukuda-Yuzawa, Yoko, Yashiro, Masakazu, Fukayama, Masashi, Fukao, Taro, Sasakawa, Chihiro

“…Persistent colonization of the gastric mucosa by Helicobacter pylori (Hp) elicits chronic inflammation and aberrant epithelial cell proliferation, which…”
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Shigella IpaH7.8 E3 ubiquitin ligase targets glomulin and activates inflammasomes to demolish macrophages by Suzuki, Shiho, Mimuro, Hitomi, Kim, Minsoo, Ogawa, Michinaga, Ashida, Hiroshi, Toyotome, Takahito, Franchi, Luigi, Suzuki, Masato, Sanada, Takahito, Suzuki, Toshihiko, Tsutsui, Hiroko, Núñez, Gabriel, Sasakawa, Chihiro

“…Significance Shigella modulates macrophage cell death by activating nucleotide-binding oligomerization domain–like receptor (NLR) inflammasome to secure its…”
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Characterization of an atypical Actinobacillus pleuropneumoniae serovar 2 isolate with a rough-type lipopolysaccharide by TO, Ho, AKAIKE, Yuta, KON, Michiha, KOIKE, Fumiko, SHIBUYA, Kazumoto, SASAKAWA, Chihiro, NAGAI, Shinya

“…We describe phenotypic and genetic characterization of an atypical Japanese Actinobacillus pleuropneumoniae isolate OT761. Nucleotide sequence analysis…”
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A unique bacterial tactic to circumvent the cell death crosstalk induced by blockade of caspase‐8 by Ashida, Hiroshi, Sasakawa, Chihiro, Suzuki, Toshihiko

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Efficacy of genogroup 1 based porcine epidemic diarrhea live vaccine against genogroup 2 field strain in Japan by Sato, Tetsuo, Oroku, Kazuki, Ohshima, Yoshiyuki, Furuya, Yoshiaki, Sasakawa, Chihiro

“…Porcine epidemic diarrhea (PED) is a lethal infectious disease in suckling piglets with symptoms including watery diarrhea caused by PED virus (PEDV). Since…”
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The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response by Sanada, Takahito, Kim, Minsoo, Mimuro, Hitomi, Suzuki, Masato, Ogawa, Michinaga, Oyama, Akiho, Ashida, Hiroshi, Kobayashi, Taira, Koyama, Tomohiro, Nagai, Shinya, Shibata, Yuri, Gohda, Jin, Inoue, Jun-ichiro, Mizushima, Tsunehiro, Sasakawa, Chihiro

“…Shigella flexneri translocates several virulence factors into host cells during infection; one of these proteins, OspI, is a glutamine deamidase that…”
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BabA-mediated Adherence Is a Potentiator of the Helicobacter pylori Type IV Secretion System Activity by Ishijima, Nozomi, Suzuki, Masato, Ashida, Hiroshi, Ichikawa, Yusuke, Kanegae, Yumi, Saito, Izumu, Borén, Thomas, Haas, Rainer, Sasakawa, Chihiro, Mimuro, Hitomi

“…Chronic infection of Helicobacter pylori in the stomach mucosa with translocation of the bacterial cytotoxin-associated gene A (CagA) effector protein via the…”
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