Search Results - "Sasagawa, Satoru"

Lung fibrosis is a novel therapeutic target to suppress lung metastasis of osteosarcoma by Yui, Yoshihiro, Kumai, Jun, Watanabe, Kenta, Wakamatsu, Toru, Sasagawa, Satoru

“…The prognosis of patients with metastatic and recurrent osteosarcoma has not improved over the last 30 years because no effective treatment strategy has been…”
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The CDK4/6-UCHL5-BRD4 axis confers resistance to BET inhibitors in MLL-rearranged leukemia cells by suppressing BRD4 protein degradation by Amari, Keigo, Sasagawa, Satoru, Imayoshi, Natsuki, Toda, Yuki, Hosogi, Shigekuni, Imamura, Toshihiko, Ashihara, Eishi

“…Among acute leukemias, mixed-lineage leukemia-rearranged (MLL-r) leukemia is associated with poor prognosis. Bromodomain and extra-terminal inhibitors (BETi)…”
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Generation of hyaline cartilaginous tissue from mouse adult dermal fibroblast culture by defined factors by Hiramatsu, Kunihiko, Sasagawa, Satoru, Outani, Hidetatsu, Nakagawa, Kanako, Yoshikawa, Hideki, Tsumaki, Noriyuki

“…Repair of cartilage injury with hyaline cartilage continues to be a challenging clinical problem. Because of the limited number of chondrocytes in vivo,…”
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Evidence for intrathecal sodium butyrate as a novel option for leptomeningeal metastasis by Nakagawa, Hidemitsu, Yui, Yoshihiro, Sasagawa, Satoru, Itoh, Kazuyuki

“…Introduction The prognosis for leptomeningeal metastasis (LM) remains extremely poor regardless of intrathecal chemotherapy with various drugs, and thus, new…”
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A Novel Method for Polyacrylamide Gel Preparation Using N-hydroxysuccinimide-acrylamide Ester to Study Cell-Extracellular Matrix Mechanical Interactions by Kumai, Jun, Sasagawa, Satoru, Horie, Masanobu, Yui, Yoshihiro

“…Mechanical stimulation by the extracellular matrix (ECM) controls physiological and pathological cellular responses, such as stem cell differentiation,…”
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Prediction and validation of the distinct dynamics of transient and sustained ERK activation by Kuroda, Shinya, Sasagawa, Satoru, Ozaki, Yu-ichi, Fujita, Kazuhiro

“…To elucidate the hidden dynamics of extracellular-signal-regulated kinase (ERK) signalling networks, we developed a simulation model of ERK signalling networks…”
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Molecular evidence of IGFBP-3 dependent and independent VD3 action and its nonlinear response on IGFBP-3 induction in prostate cancer cells by Igarashi, Ko, Yui, Yoshihiro, Watanabe, Kenta, Kumai, Jun, Nishizawa, Yasuko, Miyaura, Chisato, Inada, Masaki, Sasagawa, Satoru

“…Clinical trials have been conducted to clarify the beneficial effects of VD3 (1α,25-dihydroxy vitamin D3, also known as calcitriol) treatment in prostate…”
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SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice by Sasagawa, Satoru, Takemori, Hiroshi, Uebi, Tatsuya, Ikegami, Daisuke, Hiramatsu, Kunihiko, Ikegawa, Shiro, Yoshikawa, Hideki, Tsumaki, Noriyuki

“…Chondrocyte hypertrophy is crucial for endochondral ossification, but the mechanism underlying this process is not fully understood. We report that…”
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Establishment of Organoids From Human Epithelioid Sarcoma With the Air-Liquid Interface Organoid Cultures by Wakamatsu, Toru, Ogawa, Hisataka, Yoshida, Keiichi, Matsuoka, Yukiko, Shizuma, Kazuko, Imura, Yoshinori, Tamiya, Hironari, Nakai, Sho, Yagi, Toshinari, Nagata, Shigenori, Yui, Yoshihiro, Sasagawa, Satoru, Takenaka, Satoshi

“…Although biological resources are essential for basic and preclinical research in the oncological field, those of sarcoma are not sufficient for rapid…”
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ERVK13-1/miR-873-5p/GNMT Axis Promotes Metastatic Potential in Human Bladder Cancer though Sarcosine Production by Kishi, Shingo, Mori, Shiori, Fujiwara-Tani, Rina, Ogata, Ruiko, Sasaki, Rika, Ikemoto, Ayaka, Goto, Kei, Sasaki, Takamitsu, Miyake, Makito, Sasagawa, Satoru, Kawaichi, Masashi, Luo, Yi, Bhawal, Ujjal Kumar, Fujimoto, Kiyohide, Nakagawa, Hidemitsu, Kuniyasu, Hiroki

“…N-methyl-glycine (sarcosine) is known to promote metastatic potential in some cancers; however, its effects on bladder cancer are unclear. T24 cells derived…”
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HGF-MET signals via the MLL-ETS2 complex in hepatocellular carcinoma by Takeda, Shugaku, Liu, Han, Sasagawa, Satoru, Dong, Yiyu, Trainor, Paul A, Cheng, Emily H, Hsieh, James J

“…HGF signals through its cognate receptor, MET, to orchestrate diverse biological processes, including cell proliferation, cell fate specification,…”
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Deflection of vascular endothelial growth factor action by SS18–SSX and composite vascular endothelial growth factor‐ and chemokine (C‐X‐C motif) receptor 4‐targeted therapy in synovial sarcoma by Wakamatsu, Toru, Naka, Norifumi, Sasagawa, Satoru, Tanaka, Takaaki, Takenaka, Satoshi, Araki, Nobuhito, Ueda, Takafumi, Nishizawa, Yasuko, Yoshikawa, Hideki, Itoh, Kazuyuki

“…Synovial sarcoma (SS) is a malignant soft‐tissue tumor characterized by the recurrent chromosomal translocation SS18–SSX. Vascular endothelial growth factor…”
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Genetic characterization of a novel organoid from human malignant giant-cell tumor by Suzuki, Rie, Wakamatsu, Toru, Yoshida, Keiichi, Matsuoka, Yukiko, Takami, Haruna, Nakai, Sho, Tamiya, Hironari, Kakunaga, Shigeki, Yagi, Toshinari, Yoshida, Ken-ichi, Imura, Yoshinori, Yui, Yoshihiro, Sasagawa, Satoru, Takenaka, Satoshi

“…•We investigated the genomic characteristics of our established novel organoids from human MGCTs.•Our novel organoid model was genetically confirmed to be a…”
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Cleavage of TFIIA by Taspase1 Activates TRF2-Specified Mammalian Male Germ Cell Programs by Oyama, Toshinao, Sasagawa, Satoru, Takeda, Shugaku, Hess, Rex A., Lieberman, Paul M., Cheng, Emily H., Hsieh, James J.

“…The evolution of tissue-specific general transcription factors (GTFs), such as testis-specific TBP-related factor 2 (TRF2), enables the spatiotemporal…”
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Involvement of SIK3 in glucose and lipid homeostasis in mice by Uebi, Tatsuya, Itoh, Yumi, Hatano, Osamu, Kumagai, Ayako, Sanosaka, Masato, Sasaki, Tsutomu, Sasagawa, Satoru, Doi, Junko, Tatsumi, Keita, Mitamura, Kuniko, Morii, Eiichi, Aozasa, Katsuyuki, Kawamura, Tomohiro, Okumura, Meinoshin, Nakae, Jun, Takikawa, Hajime, Fukusato, Toshio, Koura, Minako, Nish, Mayumi, Hamsten, Anders, Silveira, Angela, Bertorello, Alejandro M, Kitagawa, Kazuo, Nagaoka, Yasuo, Kawahara, Hidehisa, Tomonaga, Takeshi, Naka, Tetsuji, Ikegawa, Shigeo, Tsumaki, Noriyuki, Matsuda, Junichiro, Takemori, Hiroshi

“…Salt-inducible kinase 3 (SIK3), an AMP-activated protein kinase-related kinase, is induced in the murine liver after the consumption of a diet rich in fat,…”
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p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage by Tu, Ho-Chou, Ren, Decheng, Wang, Gary X, Chen, David Y, Westergard, Todd D, Kim, Hyungjin, Sasagawa, Satoru, Hsieh, James J.-D, Cheng, Emily H.-Y

“…Three forms of cell death have been described: apoptosis, autophagic cell death, and necrosis. Although genetic and biochemical studies have formulated a…”
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Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression by Takeda, Shugaku, Chen, David Y, Westergard, Todd D, Fisher, Jill K, Rubens, Jeffrey A, Sasagawa, Satoru, Kan, Jason T, Korsmeyer, Stanley J, Cheng, Emily H-Y, Hsieh, James J-D

“…Taspase1 was identified as the threonine endopeptidase that cleaves mixed-lineage leukemia (MLL) for proper Hox gene expression in vitro. To investigate its…”
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Trabectedin is a promising antitumour agent for synovial sarcoma by Yasui, Hirohiko, Imura, Yoshinori, Outani, Hidetatsu, Hamada, Ken-ichiro, Nakai, Takaaki, Yamada, Shutaro, Takenaka, Satoshi, Sasagawa, Satoru, Araki, Nobuhito, Itoh, Kazuyuki, Myoui, Akira, Yoshikawa, Hideki, Naka, Norifumi

“…Synovial sarcoma (SS) is an aggressive soft tissue tumour with poor prognosis. Using five human SS cell lines, we examined the cytotoxic effects of trabectedin…”
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Dynamic Characteristics of Transient Responses by Ozaki, Yu-ichi, Sasagawa, Satoru, Kuroda, Shinya

“…Transient responses of signaling molecules are seen in a wide variety of cellular processes that are mediated by distinct molecular mechanisms. Although…”
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Improved mRNA electroporation method for Xenopus neurula embryos by Sasagawa, Satoru, Takabatake, Takashi, Takabatake, Yuka, Muramatsu, Tatsuo, Takeshima, Kazuhito

“…Electroporation has led to new approaches to the analysis of gene regulation of the chick embryonic system. However, application of this method to Xenopus,…”
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