Search Results - "Sas, Kelli"

New insights into the mechanisms of diabetic complications: role of lipids and lipid metabolism by Eid, Stephanie, Sas, Kelli M., Abcouwer, Steven F., Feldman, Eva L., Gardner, Thomas W., Pennathur, Subramaniam, Fort, Patrice E.

“…Diabetes adversely affects multiple organs, including the kidney, eye and nerve, leading to diabetic kidney disease, diabetic retinopathy and diabetic…”
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Metabolomics and diabetes: analytical and computational approaches by Sas, Kelli M, Karnovsky, Alla, Michailidis, George, Pennathur, Subramaniam

“…Diabetes is characterized by altered metabolism of key molecules and regulatory pathways. The phenotypic expression of diabetes and associated complications…”
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Impaired β -Oxidation and Altered Complex Lipid Fatty Acid Partitioning with Advancing CKD by Afshinnia, Farsad, Rajendiran, Thekkelnaycke M, Soni, Tanu, Byun, Jaeman, Wernisch, Stefanie, Sas, Kelli M, Hawkins, Jennifer, Bellovich, Keith, Gipson, Debbie, Michailidis, George, Pennathur, Subramaniam

“…Studies of lipids in CKD, including ESRD, have been limited to measures of conventional lipid profiles. We aimed to systematically identify 17 different lipid…”
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Sirtuin 1 deletion increases inflammation and mortality in sepsis by Labiner, Hanna E., Sas, Kelli M., Baur, Joseph A., Sims, Carrie A.

“…Sepsis is a hyperinflammatory response to infection that can lead to multiorgan failure and eventually death. Often, the onset of multiorgan failure is…”
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SIRT1 downregulation in pneumonia is associated with an immature neutrophil response and increased disease severity by Labiner, Hanna E, Sas, Kelli M, Hoying, Joseph, Sepeda, Jesse A, Wolf, Nick, Perez, Emma C, Sas, Andrew R, Sims, Carrie A

“…Pneumonia remains a common complication in trauma patients. Sirtuin 1 (SIRT1) is an anti-inflammatory NAD + -dependent deacetylase that has been shown to…”
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Shared and distinct lipid-lipid interactions in plasma and affected tissues in a diabetic mouse model by Sas, Kelli M., Lin, Jiahe, Rajendiran, Thekkelnaycke M., Soni, Tanu, Nair, Viji, Hinder, Lucy M., Jagadish, Hosagrahar V., Gardner, Thomas W., Abcouwer, Steven F., Brosius, Frank C., Feldman, Eva L., Kretzler, Matthias, Michailidis, George, Pennathur, Subramaniam

“…Lipids are ubiquitous metabolites with diverse functions; abnormalities in lipid metabolism appear to be related to complications from multiple diseases,…”
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Sirt3 Deletion Increases Inflammation and Mortality in Polymicrobial Sepsis by Labiner, Hanna E, Sas, Kelli M, Baur, Joseph A, Sims, Carrie A

“…Sirtuin 3 (SIRT3) is a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase that confers resilience to cellular stress by promoting mitochondrial…”
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Tissue-specific metabolic reprogramming drives nutrient flux in diabetic complications by Sas, Kelli M, Kayampilly, Pradeep, Byun, Jaeman, Nair, Viji, Hinder, Lucy M, Hur, Junguk, Zhang, Hongyu, Lin, Chengmao, Qi, Nathan R, Michailidis, George, Groop, Per-Henrik, Nelson, Robert G, Darshi, Manjula, Sharma, Kumar, Schelling, Jeffrey R, Sedor, John R, Pop-Busui, Rodica, Weinberg, Joel M, Soleimanpour, Scott A, Abcouwer, Steven F, Gardner, Thomas W, Burant, Charles F, Feldman, Eva L, Kretzler, Matthias, Brosius, 3rd, Frank C, Pennathur, Subramaniam

“…Diabetes is associated with altered cellular metabolism, but how altered metabolism contributes to the development of diabetic complications is unknown. We…”
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Kidney triglyceride accumulation in the fasted mouse is dependent upon serum free fatty acids[S] by Scerbo, Diego, Son, Ni-Huiping, Sirwi, Alaa, Zeng, Lixia, Sas, Kelli M., Cifarelli, Vincenza, Schoiswohl, Gabriele, Huggins, Lesley-Ann, Gumaste, Namrata, Hu, Yunying, Pennathur, Subramaniam, Abumrad, Nada A., Kershaw, Erin E., Hussain, M. Mahmood, Susztak, Katalin, Goldberg, Ira J.

“…Lipid accumulation is a pathological feature of every type of kidney injury. Despite this striking histological feature, physiological accumulation of lipids…”
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Mitochondrial uncoupling has no effect on microvascular complications in type 2 diabetes by Hinder, Lucy M., Sas, Kelli M., O’Brien, Phillipe D., Backus, Carey, Kayampilly, Pradeep, Hayes, John M., Lin, Cheng-mao, Zhang, Hongyu, Shanmugam, Sumathi, Rumora, Amy E., Abcouwer, Steven F., Brosius, Frank C., Pennathur, Subramaniam, Feldman, Eva L.

“…Diabetic peripheral neuropathy (DPN), diabetic kidney disease (DKD), and diabetic retinopathy (DR) contribute to significant morbidity and mortality in…”
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Renin-angiotensin system inhibition reverses the altered triacylglycerol metabolic network in diabetic kidney disease by Sas, Kelli M., Lin, Jiahe, Wang, Chih-Hong, Zhang, Hongyu, Saha, Jharna, Rajendiran, Thekkelnaycke M., Soni, Tanu, Nair, Viji, Eichinger, Felix, Kretzler, Matthias, Brosius, Frank C., Michailidis, George, Pennathur, Subramaniam

“…Objective Dyslipidemia is a significant risk factor for progression of diabetic kidney disease (DKD). Determining the changes in individual lipids and lipid…”
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Targeting B-Raf as a treatment strategy for polycystic kidney disease by Sas, Kelli M

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Aldose Reductase Acts as a Selective Derepressor of PPARγ and the Retinoic Acid Receptor by Thiagarajan, Devi, Ananthakrishnan, Radha, Zhang, Jinghua, O’Shea, Karen M., Quadri, Nosirudeen, Li, Qing, Sas, Kelli, Jing, Xiao, Rosario, Rosa, Pennathur, Subramaniam, Schmidt, Ann Marie, Ramasamy, Ravichandran

“…Histone deacetylase 3 (HDAC3), a chromatin-modifying enzyme, requires association with the deacetylase-containing domain (DAD) of the nuclear receptor…”
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Hyperglycemia in the absence of cilia accelerates cystogenesis and induces renal damage by Sas, Kelli M, Yin, Hong, Fitzgibbon, Wayne R, Baicu, Catalin F, Zile, Michael R, Steele, Stacy L, Amria, May, Saigusa, Takamitsu, Funk, Jason, Bunni, Marlene A, Siegal, Gene P, Siroky, Brian J, Bissler, John J, Bell, P Darwin

“…In polycystic kidney disease (PKD), the rate of cyst formation and disease progression is highly variable. The lack of predictability in disease progression…”
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Deletion of airway cilia results in noninflammatory bronchiectasis and hyperreactive airways by Gilley, Sandra K, Stenbit, Antine E, Pasek, Raymond C, Sas, Kelli M, Steele, Stacy L, Amria, May, Bunni, Marlene A, Estell, Kimberly P, Schwiebert, Lisa M, Flume, Patrick, Gooz, Monika, Haycraft, Courtney J, Yoder, Bradley K, Miller, Caroline, Pavlik, Jacqueline A, Turner, Grant A, Sisson, Joseph H, Bell, P Darwin

“…The mechanisms for the development of bronchiectasis and airway hyperreactivity have not been fully elucidated. Although genetic, acquired diseases and…”
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Altered Expression of Zonula occludens-1 Affects Cardiac Na + Channels and Increases Susceptibility to Ventricular Arrhythmias by El Refaey, Mona, Coles, Sara, Musa, Hassan, Stevens, Tyler L, Wallace, Michael J, Murphy, Nathaniel P, Antwi-Boasiako, Steve, Young, Lindsay J, Manring, Heather R, Curran, Jerry, Makara, Michael A, Sas, Kelli, Han, Mei, Koenig, Sara N, Skaf, Michel, Kline, Crystal F, Janssen, Paul M L, Accornero, Federica, Borzok, Maegen A, Mohler, Peter J

“…Zonula occludens-1 (ZO-1) is an intracellular scaffolding protein that orchestrates the anchoring of membrane proteins to the cytoskeleton in epithelial and…”
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Brevetoxin-2 induces an inflammatory response in an alveolar macrophage cell line by Sas, Kelli M., Baatz, John E.

“…Brevetoxins, the algal toxins produced by Karenia brevis during red tide blooms, adversely impact health following ingestion or inhalation. Inhalation of…”
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Cilia movement regulates expression of the Raf-1 kinase inhibitor protein by Sas, Kelli M, Janech, Michael G, Favre, Elizabeth, Arthur, John M, Bell, P Darwin

“…Renal epithelial cell primary cilia act as mechanosensors in response to changes in luminal fluid flow. To determine the role of cilia bending in the…”
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The deacylase sirtuin 5 reduces malonylation in nonmitochondrial metabolic pathways in diabetic kidney disease by Baek, Judy, Sas, Kelli, He, Chenchen, Nair, Viji, Giblin, William, Inoki, Ayaka, Zhang, Hongyu, Yingbao, Yang, Hodgin, Jeffrey, Nelson, Robert G., Brosius, Frank C., Kretzler, Matthias, Stemmer, Paul M., Lombard, David B., Pennathur, Subramaniam

“…Early diabetic kidney disease (DKD) is marked by dramatic metabolic reprogramming due to nutrient excess, mitochondrial dysfunction, and increased renal energy…”
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Proposing a validation scheme for .sup.13C metabolite tracer studies in high-resolution mass spectrometry by Schwaiger-Haber, Michaela, Hermann, Gerrit, El Abiead, Yasin, Rampler, Evelyn, Wernisch, Stefanie, Sas, Kelli, Pennathur, Subramaniam

“…sup.13C metabolite tracer and metabolic flux analyses require upfront experimental planning and validation tools. Here, we present a validation scheme…”
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