Alkaline Proteases from Haloalkaliphiles: Unveiling Nature’s Catalysts for Diverse Applications

Alkaline Proteases from Haloalkaliphiles: Unveiling Nature’s Catalysts for Diverse Applications

Alkaline proteases derived from haloalkaliphiles, extremophilic microorganisms thriving in high-pH and high-salt environments, have garnered significant attention in recent years due to their unique biochemical properties and versatile applications. This review highlights the isolation, characteriza...

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Bibliographic Details
Published in:Applied biochemistry and microbiology Vol. 60; no. 5; pp. 855 - 870
Main Authors: Sarwa, N., Kumari, P., Meena, D., Udawat, P., Chaudhary, N. S.
Format: Journal Article
Language:English
Published: Moscow Pleiades Publishing 01-10-2024
Springer Nature B.V
Subjects:
Alkaline soils
Alkalinity
Biocatalysts
Biochemistry
Biomedical and Life Sciences
Biotechnology
Catalysts
Enzymes
Food industry
Food processing
Industrial applications
Leather
Life Sciences
Medical Microbiology
Microbiology
Microorganisms
pH effects
Saline environments
Saline soils
Salinity
Salinity effects
Sodic soils
Soil microorganisms
Soil temperature
Structural stability
Substrate specificity
Substrates
Sustainable development
Tannery wastes
Waste treatment
halotolerant proteases
detergent
industrial applications
alkaline protease
haloalkaliphiles
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Summary:Alkaline proteases derived from haloalkaliphiles, extremophilic microorganisms thriving in high-pH and high-salt environments, have garnered significant attention in recent years due to their unique biochemical properties and versatile applications. This review highlights the isolation, characterization, and biotechnological potential of alkaline proteases produced by haloalkaliphilic microorganisms. Haloalkaliphiles, found in soda lakes, saline-sodic soils, and other extreme habitats, have evolved to adapt and thrive under conditions characterized by elevated alkalinity and salinity. Alkaline proteases from these microorganisms exhibit high stability and activity under extreme pH and salinity, making them valuable candidates for various industrial processes. The review provides insights into the biochemical properties of alkaline proteases, including optimal pH, temperature, stability, and substrate specificity. Molecular studies have revealed unique structural features that contribute to the stability of these enzymes under harsh conditions, shedding light on their potential applications in challenging industrial processes. The industrial applications of alkaline proteases from haloalkaliphiles are diverse and encompass several sectors. Their role as powerful biocatalysts in detergent formulations is well-established, where they effectively break down proteinaceous stains under high pH conditions. Additionally, these enzymes find applications in leather processing, food industry, waste treatment, and pharmaceuticals, owing to their ability to operate efficiently in alkaline and saline environments. Their stability under extreme conditions, coupled with advances in biotechnological approaches, positions these enzymes as crucial components in the development of sustainable and efficient processes across various industries. Continued research in this field holds promise for discovering novel enzymes and unlocking their full potential for biotechnological innovation.
ISSN:0003-6838
1608-3024
DOI:10.1134/S0003683824603676