Search Results - "Sartori, A"

RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection by Chapman, J. Ross, Barral, Patricia, Vannier, Jean-Baptiste, Borel, Valérie, Steger, Martin, Tomas-Loba, Antonia, Sartori, Alessandro A., Adams, Ian R., Batista, Facundo D., Boulton, Simon J.

“…The appropriate execution of DNA double-strand break (DSB) repair is critical for genome stability and tumor avoidance. 53BP1 and BRCA1 directly influence DSB…”
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Noncanonical Mismatch Repair as a Source of Genomic Instability in Human Cells by Peña-Diaz, Javier, Bregenhorn, Stephanie, Ghodgaonkar, Medini, Follonier, Cindy, Artola-Borán, Mariela, Castor, Dennis, Lopes, Massimo, Sartori, Alessandro A., Jiricny, Josef

“…Mismatch repair (MMR) is a key antimutagenic process that increases the fidelity of DNA replication and recombination. Yet genetic experiments showed that MMR…”
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CDK targets Sae2 to control DNA-end resection and homologous recombination by Sartori, Alessandro A, Aguilera, Andrés, Cortés-Ledesma, Felipe, Huertas, Pablo, Jackson, Stephen P

“…DNA double-strand breaks (DSBs) are repaired by two principal mechanisms: non-homologous end-joining (NHEJ) and homologous recombination (HR). HR is the most…”
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A Short BRCA2-Derived Cell-Penetrating Peptide Targets RAD51 Function and Confers Hypersensitivity toward PARP Inhibition by Trenner, Anika, Godau, Julia, Sartori, Alessandro A

“…Under conditions of genotoxic stress, cancer cells strongly rely on efficient DNA repair to survive and proliferate. The human BRCA2 tumor suppressor protein…”
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Spin-dipole oscillation and relaxation of coherently coupled Bose-Einstein condensates by Sartori, A, Marino, J, Stringari, S, Recati, A

“…We study the static and the dynamic response of coherently coupled two component Bose-Einstein condensates due to a spin-dipole perturbation. The static dipole…”
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Harnessing DNA Double-Strand Break Repair for Cancer Treatment by Trenner, Anika, Sartori, Alessandro A

“…DNA double-strand breaks (DSBs) are highly deleterious, with a single unrepaired DSB being sufficient to trigger cell death. Compared to healthy cells, cancer…”
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Deficiency in Homologous Recombination Renders Mammalian Cells More Sensitive to Proton Versus Photon Irradiation by Grosse, Nicole, PhD, Fontana, Andrea O., MSc, Hug, Eugen B., MD, Lomax, Antony, PhD, Coray, Adolf, PhD, Augsburger, Marc, MSc, Paganetti, Harald, PhD, Sartori, Alessandro A., PhD, Pruschy, Martin, PhD

“…Purpose To investigate the impact of the 2 major DNA repair machineries on cellular survival in response to irradiation with the 2 types of ionizing radiation…”
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Clinical activity after fingolimod cessation: disease reactivation or rebound? by Frau, J., Sormani, M. P., Signori, A., Realmuto, S., Baroncini, D., Annovazzi, P., Signoriello, E., Maniscalco, G. T., La Gioia, S., Cordioli, C., Frigeni, B., Rasia, S., Fenu, G., Grasso, R., Sartori, A., Lanzillo, R., Stromillo, M. L., Rossi, S., Forci, B., Cocco, E.

“…Background and purpose There is debate as to whether the apparent rebound after fingolimod discontinuation is related to the discontinuation itself or whether…”
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Pre-vaccination screening strategies for the use of the CYD-TDV dengue vaccine: A meeting report by Wilder-Smith, A., Smith, P.G., Luo, R., Kelly-Cirino, C., Curry, D., Larson, H., Durbin, A., Chu, M., Tharmaphornpilas, P., Ng, L.C., Sartori, A.M.C., Luna, E.J.A., Gubler, D.J., España, G., Yoon, I.K., Flasche, S.

“…The first licensed dengue vaccine, CYD-TDV (Dengvaxia) is efficacious in seropositive individuals, but increases the risk for severe dengue in seronegative…”
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Differential DNA repair pathway choice in cancer cells after proton- and photon-irradiation by Fontana, Andrea O, Augsburger, Marc A, Grosse, Nicole, Guckenberger, Matthias, Lomax, Anthony J, Sartori, Alessandro A, Pruschy, Martin N

“…Abstract Background and purpose Non-homologous end-joining (NHEJ) and homologous recombination (HR) contribute to the repair of irradiation-induced DNA…”
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Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells by Toller, Isabella M, Neelsen, Kai J, Steger, Martin, Hartung, Mara L, Hottiger, Michael O, Stucki, Manuel, Kalali, Behnam, Gerhard, Markus, Sartori, Alessandro A, Lopes, Massimo, Müller, Anne

“…The bacterial pathogen Helicobacter pylori chronically infects the human gastric mucosa and is the leading risk factor for the development of gastric cancer…”
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Deficiency of FANCD2-Associated Nuclease KIAA1018/FAN1 Sensitizes Cells to Interstrand Crosslinking Agents by Kratz, Katja, Schöpf, Barbara, Kaden, Svenja, Sendoel, Ataman, Eberhard, Ralf, Lademann, Claudio, Cannavó, Elda, Sartori, Alessandro A., Hengartner, Michael O., Jiricny, Josef

“…Cytotoxicity of cisplatin and mitomycin C (MMC) is ascribed largely to their ability to generate interstrand crosslinks (ICLs) in DNA, which block the…”
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System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes by Zhang, Wei, Wu, Kuen-Phon, Sartori, Maria A., Kamadurai, Hari B., Ordureau, Alban, Jiang, Chong, Mercredi, Peter Y., Murchie, Ryan, Hu, Jicheng, Persaud, Avinash, Mukherjee, Manjeet, Li, Nan, Doye, Anne, Walker, John R., Sheng, Yi, Hao, Zhenyue, Li, Yanjun, Brown, Kevin R., Lemichez, Emmanuel, Chen, Junjie, Tong, Yufeng, Harper, J. Wade, Moffat, Jason, Rotin, Daniela, Schulman, Brenda A., Sidhu, Sachdev S.

“…HECT-family E3 ligases ubiquitinate protein substrates to control virtually every eukaryotic process and are misregulated in numerous diseases. Nonetheless,…”
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Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1–F-box interface by Gorelik, Maryna, Orlicky, Stephen, Sartori, Maria A., Tang, Xiaojing, Marcon, Edyta, Kurinov, Igor, Greenblatt, Jack F., Tyers, Mike, Moffat, Jason, Sicheri, Frank, Sidhu, Sachdev S.

“…Skp1–Cul1–F-box (SCF) E3 ligases play key roles in multiple cellular processes through ubiquitination and subsequent degradation of substrate proteins…”
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Nationwide analysis of open groin hernia repairs in Italy from 2015 to 2020 by Ortenzi, M., Botteri, E., Balla, A., Podda, M., Montori, G., Sartori, A.

“…Introduction Inguinal hernia repair is one of the most commonly performed operations in general surgery. A total of 130.000 inguinal hernia repairs are…”
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FANCD2 and CtIP Cooperate to Repair DNA Interstrand Crosslinks by Murina, Olga, von Aesch, Christine, Karakus, Ufuk, Ferretti, Lorenza P., Bolck, Hella A., Hänggi, Kay, Sartori, Alessandro A.

“…The resolution of DNA interstrand crosslinks (ICLs) requires a complex interplay between several processes of DNA metabolism, including the Fanconi anemia (FA)…”
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FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntington’s disease by Goold, Robert, Hamilton, Joseph, Menneteau, Thomas, Flower, Michael, Bunting, Emma L., Aldous, Sarah G., Porro, Antonio, Vicente, José R., Allen, Nicholas D., Wilkinson, Hilary, Bates, Gillian P., Sartori, Alessandro A., Thalassinos, Konstantinos, Balmus, Gabriel, Tabrizi, Sarah J.

“…CAG repeat expansion in the HTT gene drives Huntington’s disease (HD) pathogenesis and is modulated by DNA damage repair pathways. In this context, the…”
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γ-Radiation promotes immunological recognition of cancer cells through increased expression of cancer-testis antigens in vitro and in vivo by Sharma, Anu, Bode, Beata, Wenger, Roland H, Lehmann, Kuno, Sartori, Alessandro A, Moch, Holger, Knuth, Alexander, Boehmer, Lotta von, Broek, Maries van den

“…γ-radiation is an effective treatment for cancer. There is evidence that radiotherapy supports tumor-specific immunity. It was described that irradiation…”
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Shifts in Ribosome Engagement Impact Key Gene Sets in Neurodevelopment and Ubiquitination in Rett Syndrome by Rodrigues, Deivid C., Mufteev, Marat, Weatheritt, Robert J., Djuric, Ugljesa, Ha, Kevin C.H., Ross, P. Joel, Wei, Wei, Piekna, Alina, Sartori, Maria A., Byres, Loryn, Mok, Rebecca S.F., Zaslavsky, Kirill, Pasceri, Peter, Diamandis, Phedias, Morris, Quaid, Blencowe, Benjamin J., Ellis, James

“…Regulation of translation during human development is poorly understood, and its dysregulation is associated with Rett syndrome (RTT). To discover shifts in…”
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FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2 by Porro, Antonio, Berti, Matteo, Pizzolato, Julia, Bologna, Serena, Kaden, Svenja, Saxer, Anja, Ma, Yue, Nagasawa, Kazuo, Sartori, Alessandro A., Jiricny, Josef

“…Interstrand cross-link (ICL) hypersensitivity is a characteristic trait of Fanconi anemia (FA). Although FANCD2-associated nuclease 1 (FAN1) contributes to ICL…”
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