Search Results - "Sartor, A"

annotatr: genomic regions in context by Cavalcante, Raymond G, Sartor, Maureen A

“…Analysis of next-generation sequencing data often results in a list of genomic regions. These may include differentially methylated CpGs/regions, transcription…”
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Metastatic castration‐sensitive prostate cancer: Abiraterone, docetaxel, or by Barata, Pedro C., Sartor, A. Oliver

“…For decades, the management of patients with advanced prostate cancer has been hormonal therapy, known as androgen deprivation therapy, which is intended to…”
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Machine learning approaches and databases for prediction of drug–target interaction: a survey paper by Bagherian, Maryam, Sabeti, Elyas, Wang, Kai, Sartor, Maureen A, Nikolovska-Coleska, Zaneta, Najarian, Kayvan

“…Abstract The task of predicting the interactions between drugs and targets plays a key role in the process of drug discovery. There is a need to develop novel…”
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Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial by de Bono, Johann Sebastian, Dr, Oudard, Stephane, MD, Ozguroglu, Mustafa, MD, Hansen, Steinbjørn, MD, Machiels, Jean-Pascal, MD, Kocak, Ivo, MD, Gravis, Gwenaëlle, MD, Bodrogi, Istvan, MD, Mackenzie, Mary J, MD, Shen, Liji, PhD, Roessner, Martin, MS, Gupta, Sunil, MD, Sartor, A Oliver, MD

“…Summary Background Cabazitaxel is a novel tubulin-binding taxane drug with antitumour activity in docetaxel-resistant cancers. We aimed to compare the efficacy…”
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ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death by Han, Jaeseok, Back, Sung Hoon, Hur, Junguk, Lin, Yu-Hsuan, Gildersleeve, Robert, Shan, Jixiu, Yuan, Celvie L., Krokowski, Dawid, Wang, Shiyu, Hatzoglou, Maria, Kilberg, Michael S., Sartor, Maureen A., Kaufman, Randal J.

“…Protein misfolding in the endoplasmic reticulum (ER) leads to cell death through PERK-mediated phosphorylation of eIF2α, although the mechanism is not…”
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MethylSig: a whole genome DNA methylation analysis pipeline by Park, Yongseok, Figueroa, Maria E, Rozek, Laura S, Sartor, Maureen A

“…DNA methylation plays critical roles in gene regulation and cellular specification without altering DNA sequences. The wide application of reduced…”
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The association between germline BRCA2 variants and sensitivity to platinum‐based chemotherapy among men with metastatic prostate cancer by Pomerantz, Mark M., Spisák, Sandor, Jia, Li, Cronin, Angel M., Csabai, Istvan, Ledet, Elisa, Sartor, A. Oliver, Rainville, Irene, O'Connor, Edward P., Herbert, Zachary T., Szállási, Zoltan, Oh, William K., Kantoff, Philip W., Garber, Judy E., Schrag, Deborah, Kibel, Adam S., Freedman, Matthew L.

“…BACKGROUND Breast cancer 2 (BRCA2)‐associated breast and ovarian cancers are sensitive to platinum‐based chemotherapy. It is unknown whether BRCA2‐associated…”
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Impact of cabazitaxel on 2-year survival and palliation of tumour-related pain in men with metastatic castration-resistant prostate cancer treated in the TROPIC trial by Bahl, A., Oudard, S., Tombal, B., Özgüroĝlu, M., Hansen, S., Kocak, I., Gravis, G., Devin, J., Shen, L., de Bono, J.S., Sartor, A.O.

“…Cabazitaxel significantly improves overall survival (OS) versus mitoxantrone in patients with metastatic castration-resistant prostate cancer after docetaxel…”
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Biomarkers in the Management and Treatment of Men with Metastatic Castration-Resistant Prostate Cancer by Armstrong, Andrew J, Eisenberger, Mario A, Halabi, Susan, Oudard, Stephane, Nanus, David M, Petrylak, Daniel P, Sartor, A. Oliver, Scher, Howard I

“…Abstract Context We have recently witnessed a rapid increase in the number of effective systemic agents for men with metastatic castration-resistant prostate…”
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Real‐world outcomes of sipuleucel‐T treatment in PROCEED, a prospective registry of men with metastatic castration‐resistant prostate cancer by Higano, Celestia S., Armstrong, Andrew J., Sartor, A. Oliver, Vogelzang, Nicholas J., Kantoff, Philip W., McLeod, David G., Pieczonka, Christopher M., Penson, David F., Shore, Neal D., Vacirca, Jeffrey, Concepcion, Raoul S., Tutrone, Ronald F., Nordquist, Luke T., Quinn, David I., Kassabian, Vahan, Scholz, Mark C., Harmon, Matt, Tyler, Robert C., Chang, Nancy N., Tang, Hong, Cooperberg, Matthew R.

“…Background The large registry, PROVENGE Registry for the Observation, Collection, and Evaluation of Experience Data (PROCEED)(NCT01306890), evaluated…”
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PePr: a peak-calling prioritization pipeline to identify consistent or differential peaks from replicated ChIP-Seq data by Zhang, Yanxiao, Lin, Yu-Hsuan, Johnson, Timothy D, Rozek, Laura S, Sartor, Maureen A

“…ChIP-Seq is the standard method to identify genome-wide DNA-binding sites for transcription factors (TFs) and histone modifications. There is a growing need to…”
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MicroRNA-320 Is Involved in the Regulation of Cardiac Ischemia/Reperfusion Injury by Targeting Heat-Shock Protein 20 by REN, Xiao-Ping, JINGHAI WU, XIAOHONG WANG, SARTOR, Maureen A, JIANG QIAN, JONES, Keith, NICOLAOU, Persoulla, PRITCHARD, Tracy J, FAN, Guo-Chang

“…Recent studies have identified critical roles for microRNAs (miRNAs) in a variety of cellular processes, including regulation of cardiomyocyte death. However,…”
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Germline BLM mutations and metastatic prostate cancer by Ledet, Elisa M., Antonarakis, Emmanuel S., Isaacs, William B., Lotan, Tamara L., Pritchard, Colin, Sartor, A. Oliver

“…Background Biallelic loss‐of‐function BLM mutations result in Bloom syndrome: a genetic disorder characterized by growth deficiencies, photosensitivity, and…”
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Metscape 2 bioinformatics tool for the analysis and visualization of metabolomics and gene expression data by Karnovsky, Alla, Weymouth, Terry, Hull, Tim, Tarcea, V. Glenn, Scardoni, Giovanni, Laudanna, Carlo, Sartor, Maureen A., Stringer, Kathleen A., Jagadish, H. V., Burant, Charles, Athey, Brian, Omenn, Gilbert S.

“…Motivation: Metabolomics is a rapidly evolving field that holds promise to provide insights into genotype-phenotype relationships in cancers, diabetes and…”
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PSMA ADC monotherapy in patients with progressive metastatic castration‐resistant prostate cancer following abiraterone and/or enzalutamide: Efficacy and safety in open‐label single‐arm phase 2 study by Petrylak, Daniel P., Vogelzang, Nicholas J., Chatta, Kamal, Fleming, Mark T., Smith, David C., Appleman, Leonard J., Hussain, Arif, Modiano, Manuel, Singh, Parminder, Tagawa, Scott T., Gore, Ira, McClay, Edward F., Mega, Anthony E., Sartor, A. Oliver, Somer, Bradley, Wadlow, Raymond, Shore, Neal D., Olson, William C., Stambler, Nancy, DiPippo, Vincent A., Israel, Robert J.

“…Background Prostate‐specific membrane antigen (PSMA) is a well‐established therapeutic and diagnostic target overexpressed in both primary and metastatic…”
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A Mouse Model of X-linked Intellectual Disability Associated with Impaired Removal of Histone Methylation by Iwase, Shigeki, Brookes, Emily, Agarwal, Saurabh, Badeaux, Aimee I., Ito, Hikaru, Vallianatos, Christina N., Tomassy, Giulio Srubek, Kasza, Tomas, Lin, Grace, Thompson, Andrew, Gu, Lei, Kwan, Kenneth Y., Chen, Chinfei, Sartor, Maureen A., Egan, Brian, Xu, Jun, Shi, Yang

“…Mutations in a number of chromatin modifiers are associated with human neurological disorders. KDM5C, a histone H3 lysine 4 di- and tri-methyl…”
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Prognosis of isolated congenital diaphragmatic hernia using lung‐area‐to‐head‐circumference ratio: variability across centers in a national perinatal network by Senat, M.‐V., Bouchghoul, H., Stirnemann, J., Vaast, P., Boubnova, J., Begue, L., Carricaburu, E., Sartor, A., Jani, J., Benachi, A., Bouyer, J.

“…ABSTRACT Objective Congenital diaphragmatic hernia (CDH) is a severe anomaly. The observed‐to‐expected lung‐area‐to‐head‐circumference ratio (o/e‐LHR) has been…”
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Progression of metastatic castrate-resistant prostate cancer: impact of therapeutic intervention in the post-docetaxel space by Sartor, A Oliver

“…Despite the proven success of hormonal therapy for prostate cancer using chemical or surgical castration, most patients eventually will progress to a phase of…”
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LRpath: a logistic regression approach for identifying enriched biological groups in gene expression data by Sartor, Maureen A., Leikauf, George D., Medvedovic, Mario

“…Motivation: The elucidation of biological pathways enriched with differentially expressed genes has become an integral part of the analysis and interpretation…”
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A prospective trial of abiraterone acetate plus prednisone in Black and White men with metastatic castrate‐resistant prostate cancer by George, Daniel J., Halabi, Susan, Heath, Elisabeth I., Sartor, A. Oliver, Sonpavde, Guru P., Das, Devika, Bitting, Rhonda L., Berry, William, Healy, Patrick, Anand, Monika, Winters, Carol, Riggan, Colleen, Kephart, Julie, Wilder, Rhonda, Shobe, Kellie, Rasmussen, Julia, Milowsky, Matthew I., Fleming, Mark T., Bearden, James, Goodman, Michael, Zhang, Tian, Harrison, Michael R., McNamara, Megan, Zhang, Dadong, LaCroix, Bonnie L., Kittles, Rick A., Patierno, Brendon M., Sibley, Alexander B., Patierno, Steven R., Owzar, Kouros, Hyslop, Terry, Freedman, Jennifer A., Armstrong, Andrew J.

“…Background Retrospective analyses of randomized trials suggest that Black men with metastatic castration‐resistant prostate cancer (mCRPC) have longer survival…”
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