Search Results - "Sarsenbayeva, Assel"
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1
Evaluation of RNA Isolation Methods in Human Adipose Tissue
Published in Laboratory medicine (01-09-2022)“…Abstract Objective Research has shown that RNA extraction from adipose tissue (AT) is challenging because of high lipid content and low RNA quantity. We…”
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2
Impaired HMG-CoA Reductase Activity Caused by Genetic Variants or Statin Exposure: Impact on Human Adipose Tissue, β-Cells and Metabolome
Published in Metabolites (25-08-2021)“…Inhibition of 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase is associated with an increased risk of new-onset type 2 diabetes. We studied the association…”
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3
Macrophage-derived secretome is sufficient to confer olanzapine-mediated insulin resistance in human adipocytes
Published in Comprehensive Psychoneuroendocrinology (Online) (01-08-2021)“…Olanzapine and Aripiprazole are widely used second-generation antipsychotic drugs. Olanzapine, more than Aripiprazole, leads to considerable metabolic side…”
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The effects of bisphenol A and bisphenol S on adipokine expression and glucose metabolism in human adipose tissue
Published in Toxicology (Amsterdam) (01-12-2020)“…•BPA reduces expression of proinflammatory adipokines in human adipose tissue.•BPS has no effect on proinflammatory gene expression in human adipose…”
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Direct effects of glucagon on glucose uptake and lipolysis in human adipocytes
Published in Molecular and cellular endocrinology (01-03-2020)“…We aim to investigate the expression of the glucagon receptor (GCGR) in human adipose tissue, and the impact of glucagon in glucose uptake and lipolysis in…”
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Role of Estrogen and Its Receptors in Adipose Tissue Glucose Metabolism in Pre- and Postmenopausal Women
Published in The journal of clinical endocrinology and metabolism (19-04-2022)“…Reduced estrogen levels in postmenopausal women predispose them to metabolic side effects, including insulin resistance and type 2 diabetes; however, the…”
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Effects of the second-generation antipsychotic drugs aripiprazole and olanzapine on human adipocyte differentiation
Published in Molecular and cellular endocrinology (05-02-2023)“…Second-generation antipsychotics (SGAs), used as the cornerstone treatment for schizophrenia and other mental disorders, can cause adverse metabolic effects…”
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Modulation of hypothalamic AMPK phosphorylation by olanzapine controls energy balance and body weight
Published in Metabolism, clinical and experimental (01-12-2022)“…Second-generation antipsychotics (SGAs) are a mainstay therapy for schizophrenia. SGA-treated patients present higher risk for weight gain, dyslipidemia and…”
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Human macrophages stimulate expression of inflammatory mediators in adipocytes; effects of second-generation antipsychotics and glucocorticoids on cellular cross-talk
Published in Psychoneuroendocrinology (01-03-2021)“…Adipose tissue inflammation and distorted macrophage-adipocyte communication are positively associated with metabolic disturbances. Some pharmacological…”
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Excess glucocorticoid exposure contributes to adipose tissue fibrosis which involves macrophage interaction with adipose precursor cells
Published in Biochemical pharmacology (01-04-2022)“…[Display omitted] Chronic exposure to elevated glucocorticoid levels, as seen in patients with Cushing’s syndrome, can induce adipose tissue fibrosis…”
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Effects of second-generation antipsychotics on human subcutaneous adipose tissue metabolism
Published in Psychoneuroendocrinology (01-12-2019)“…•Therapeutic concentrations of SGAs have a mild direct effect on adipose tissue metabolism.•Olanzapine dose-dependently reduces lipolysis manner in isolated…”
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NK cell receptor NKG2D enforces proinflammatory features and pathogenicity of Th1 and Th17 cells
Published in The Journal of experimental medicine (03-08-2020)“…NKG2D is a danger sensor expressed on different subsets of innate and adaptive lymphocytes. Despite its established role as a potent activator of the immune…”
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13
In vivo Effects of Repeated Thyronamine Administration in Male C57BL/6J Mice
Published in European thyroid journal (01-01-2018)“…Objectives: Thyronamines are decarboxylated and deiodinated metabolites of thyroid hormones (THs). Of all possible thyronamine variants, only 3-iodothyronamine…”
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