Search Results - "Sarrió, David"

Prognostic Significance of Basal-Like Phenotype and Fascin Expression in Node-Negative Invasive Breast Carcinomas by RODRIGUEZ-PINILLA, Socorro Maria, SARRIO, David, HONRADO, Emiliano, HARDISSON, David, CALERO, Francisco, BENITEZ, Javier, PALACIOS, José

“…Purpose: Basal-like phenotype tumors are frequently found among BRCA1 germ-line mutated breast carcinomas. They are biologically aggressive and have a tendency…”
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The multifaceted roles of gasdermins in cancer biology and oncologic therapies by Sarrió, David, Martínez-Val, Jeannette, Molina-Crespo, Ángela, Sánchez, Laura, Moreno-Bueno, Gema

“…The involvement of the Gasdermin (GSDM) protein family in cancer and other pathologies is one of the hottest topics in biomedical research. There are six GSDMs…”
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Gasdermin-B promotes invasion and metastasis in breast cancer cells by Hergueta-Redondo, Marta, Sarrió, David, Molina-Crespo, Ángela, Megias, Diego, Mota, Alba, Rojo-Sebastian, Alejandro, García-Sanz, Pablo, Morales, Saleta, Abril, Sandra, Cano, Amparo, Peinado, Héctor, Moreno-Bueno, Gema

“…Gasdermin B (GSDMB) belongs to the Gasdermin protein family that comprises four members (GSDMA-D). Gasdermin B expression has been detected in some tumor types…”
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Novel Therapies and Strategies to Overcome Resistance to Anti-HER2-Targeted Drugs by Gámez-Chiachio, Manuel, Sarrió, David, Moreno-Bueno, Gema

“…The prognosis and quality of life of HER2 breast cancer patients have significantly improved due to the crucial clinical benefit of various anti-HER2 targeted…”
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Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for snail, slug, and E47 factors in epithelial-mesenchymal transition by MORENO-BUENO, Gema, CUBILLO, Eva, PALACIOS, José, CANO, Amparo, SARRIO, David, PEINADO, Héctor, RODRIGUEZ-PINILLA, Socorro Maria, VILLA, Sonia, BOLOS, Victoria, JORDA, Mireia, FABRA, Angels, PORTILLO, Francisco

“…The transcription factors Snail, Slug, and bHLH E47 have been recently described as direct repressors of E-cadherin and inducers of epithelial-mesenchymal…”
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MicroRNA-200 family modulation in distinct breast cancer phenotypes by Castilla, María Ángeles, Díaz-Martín, Juan, Sarrió, David, Romero-Pérez, Laura, López-García, María Ángeles, Vieites, Begoña, Biscuola, Michele, Ramiro-Fuentes, Susana, Isacke, Clare M, Palacios, José

“…The epithelial to mesenchymal transition (EMT) contributes to tumor invasion and metastasis in a variety of cancer types. In human breast cancer, gene…”
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Gasdermin B over-expression modulates HER2-targeted therapy resistance by inducing protective autophagy through Rab7 activation by Gámez-Chiachio, Manuel, Molina-Crespo, Ángela, Ramos-Nebot, Carmen, Martinez-Val, Jeannette, Martinez, Lidia, Gassner, Katja, Llobet, Francisco J., Soriano, Mario, Hernandez, Alberto, Cordani, Marco, Bernadó-Morales, Cristina, Diaz, Eva, Rojo-Sebastian, Alejandro, Triviño, Juan Carlos, Sanchez, Laura, Rodríguez-Barrueco, Ruth, Arribas, Joaquín, Llobet-Navás, David, Sarrió, David, Moreno-Bueno, Gema

“…Background Gasdermin B (GSDMB) over-expression promotes poor prognosis and aggressive behavior in HER2 breast cancer by increasing resistance to therapy…”
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Cytoplasmic localization of p120ctn and E-cadherin loss characterize lobular breast carcinoma from preinvasive to metastatic lesions by SARRIO, David, PEREZ-MIES, Belén, HARDISSON, David, MORENO-BUENO, Gema, SUAREZ, Asuncion, CANO, Amparo, MARTIN-PEREZ, Jorge, GAMALLO, Carlos, PALACIOS, José

“…Accumulating evidences indicate that p120 catenin, a member of the E-cadherin (E-CD)/catenin adhesion complex, plays a role in tumor invasion. To establish the…”
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Abnormal ezrin localization is associated with clinicopathological features in invasive breast carcinomas by SARRIO, David, RODRIGUEZ-PINILLA, Socorro Maria, DOTOR, Ana, CALERO, Francisco, HARDISSON, David, PALACIOS, José

“…The membrane-cytoskeleton crosslinker ezrin is associated with malignant progression and metastasis in human neoplasias. To study the role of ezrin in breast…”
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Abnormalities of E- and P-cadherin and catenin (β-, γ-catenin, and p120ctn) expression in endometrial cancer and endometrial atypical hyperplasia by Moreno-Bueno, Gema, Hardisson, David, Sarrió, David, Sánchez, Carolina, Cassia, Raúl, Prat, Jaime, Herman, James G, Esteller, Manel, Matías-Guiu, Xavier, Palacios, José

“…Abnormal expression of cadherins and catenins plays a critical role in the initiation and progression of multiple human tumours. This study aimed to evaluate…”
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Epithelial-Mesenchymal Transition in Breast Cancer Relates to the Basal-like Phenotype by SARRO, David, RODRIGUEZ-PINILLA, Socorro Maria, HARDISSON, David, CANO, Amparo, MORENO-BUENO, Gema, PALACIOS, José

“…Epithelial-mesenchymal transition (EMT) is defined by the loss of epithelial characteristics and the acquisition of a mesenchymal phenotype. In carcinoma…”
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Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells by Oltra, Sara S., Colomo, Sara, Sin, Laura, Pérez-López, María, Lázaro, Sara, Molina-Crespo, Angela, Choi, Kyoung-Han, Ros-Pardo, David, Martínez, Lidia, Morales, Saleta, González-Paramos, Cristina, Orantes, Alba, Soriano, Mario, Hernández, Alberto, Lluch, Ana, Rojo, Federico, Albanell, Joan, Gómez-Puertas, Paulino, Ko, Jae-Kyun, Sarrió, David, Moreno-Bueno, Gema

“…Gasdermin (GSDM)-mediated pyroptosis is functionally involved in multiple diseases, but Gasdermin-B (GSDMB) exhibit cell death-dependent and independent…”
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CDH1 methylation analysis in invasive lobular breast carcinomas with and without gene mutation by González-Martínez, Silvia, Kajabova, Viera Horvathova, Pérez-Mies, Belén, Carretero-Barrio, Irene, Caniego-Casas, Tamara, Sarrió, David, Moreno-Bueno, Gema, Gión, María, Perez-García, José, Cortés, Javier, Smolkova, Bozena, Palacios, José

“…The proposed role of CDH1 (E-cadherin gene) methylation as a mechanism of gene inactivation in invasive lobular carcinoma (ILC) remains inconclusive. For many…”
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Epithelial and Mesenchymal Subpopulations Within Normal Basal Breast Cell Lines Exhibit Distinct Stem Cell/Progenitor Properties by Sarrio, David, Franklin, Chris K., Mackay, Alan, Reis-Filho, Jorge S., Isacke, Clare M.

“…It has been proposed that epithelial–mesenchymal transition (EMT) in mammary epithelial cells and breast cancer cells generates stem cell features, and that…”
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Evaluation of ERBB2 mRNA Expression in HER2-Equivocal (2+) Immunohistochemistry Cases by Carretero-Barrio, Irene, Caniego-Casas, Tamara, Rosas, Marta, Sánchez, María Concepción, Martínez-Jáñez, Noelia, Chiva, Miguel, Sarrió, David, Moreno-Bueno, Gema, Palacios, José, Pérez-Mies, Belén

“…Xpert Breast Cancer STRAT4 is a RT-qPCR platform that studies the mRNA expression of , , and , providing a positive or negative result for each of these breast…”
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Gasdermin B expression predicts poor clinical outcome in HER2-positive breast cancer by Hergueta-Redondo, Marta, Sarrio, David, Molina-Crespo, Ángela, Vicario, Rocío, Bernadó-Morales, Cristina, Martínez, Lidia, Rojo-Sebastián, Alejandro, Serra-Musach, Jordi, Mota, Alba, Martínez-Ramírez, Ángel, Castilla, Mª Ángeles, González-Martin, Antonio, Pernas, Sonia, Cano, Amparo, Cortes, Javier, Nuciforo, Paolo G, Peg, Vicente, Palacios, José, Pujana, Miguel Ángel, Arribas, Joaquín, Moreno-Bueno, Gema

“…Around, 30-40% of HER2-positive breast cancers do not show substantial clinical benefit from the targeted therapy and, thus, the mechanisms underlying…”
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Sox2: a possible driver of the basal-like phenotype in sporadic breast cancer by Rodriguez-Pinilla, Socorro M, Sarrio, David, Moreno-Bueno, Gema, Rodriguez-Gil, Yolanda, Martinez, Miguel A, Hernandez, Lucia, Hardisson, David, Reis-Filho, Jorge S, Palacios, Jose

“…Tumours arising in BRCA1 mutation carriers and sporadic basal-like breast carcinomas have similar phenotypic, immunohistochemical and clinical characteristics…”
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FGFR1 Emerges as a Potential Therapeutic Target for Lobular Breast Carcinomas by REIS-FILHO, Jorge Sergio, SIMPSON, Pete T, IRAVANI, Marjan, FENWICK, Kerry, WEBER, Barbara, HARDISSON, David, SCHMITT, Fernando Carlos, PALACIOS, Jose, LAKHANI, Sunil R, ASHWORTH, Alan, TURNER, Nicholas C, LAMBROS, Maryou Ballo, JONES, Chris, MACKAY, Alan, GRIGORIADIS, Anita, SARRIO, David, SAVAGE, Kay, DEXTER, Tim

“…Purpose: Classic lobular carcinomas (CLC) account for 10% to 15% of all breast cancers. At the genetic level, CLCs show recurrent physical loss of…”
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Functional characterization of E- and P-cadherin in invasive breast cancer cells by Sarrió, David, Palacios, José, Hergueta-Redondo, Marta, Gómez-López, Gonzalo, Cano, Amparo, Moreno-Bueno, Gema

“…Alterations in the cadherin-catenin adhesion complexes are involved in tumor initiation, progression and metastasis. However, the functional implication of…”
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WIP and WICH/WIRE co-ordinately control invadopodium formation and maturation in human breast cancer cell invasion by García, Esther, Ragazzini, Chiara, Yu, Xinzi, Cuesta-García, Elena, Bernardino de la Serna, Jorge, Zech, Tobias, Sarrió, David, Machesky, Laura M., Antón, Inés M.

“…Cancer cells form actin-rich degradative protrusions (invasive pseudopods and invadopodia), which allows their efficient dispersal during metastasis. Using…”
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