Search Results - "Sarras, Michael P."

Heritable Transmission of Diabetic Metabolic Memory in Zebrafish Correlates With DNA Hypomethylation and Aberrant Gene Expression by OLSEN, Ansgar S, SARRAS, Michael P, LEONTOVICH, Alexey, INTINE, Robert V

“…Metabolic memory (MM) is the phenomenon whereby diabetes complications persist and progress after glycemic recovery is achieved. Here, we present data showing…”
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Limb regeneration is impaired in an adult zebrafish model of diabetes mellitus by Olsen, Ansgar S., Sarras Jr, Michael P., Intine, Robert V.

“…ABSTRACT The zebrafish (Danio rerio) is an established model organism for the study of developmental processes, human disease, and tissue regeneration. We…”
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Metabolic Memory and Chronic Diabetes Complications: Potential Role for Epigenetic Mechanisms by Intine, Robert V., Sarras, Michael P.

“…Recent estimates indicate that diabetes mellitus currently affects more than 10 % of the world’s population. Evidence from both the laboratory and large scale…”
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Components, structure, biogenesis and function of the Hydra extracellular matrix in regeneration, pattern formation and cell differentiation by Sarras, Jr, Michael P

“…The body wall of Hydra is organized as an epithelial bilayer (ectoderm and endoderm) with an intervening extracellular matrix (ECM), termed mesoglea by early…”
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A zebrafish model of diabetes mellitus and metabolic memory by Intine, Robert V, Olsen, Ansgar S, Sarras, Jr, Michael P

“…Diabetes mellitus currently affects 346 million individuals and this is projected to increase to 400 million by 2030. Evidence from both the laboratory and…”
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Parp Inhibition Prevents Ten-Eleven Translocase Enzyme Activation and Hyperglycemia-Induced DNA Demethylation by DHLIWAYO, Nyembezi, SARRAS, Michael P, LUCZKOWSKI, Ernest, MASON, Samantha M, INTINE, Robert V

“…Studies from human cells, rats, and zebrafish have documented that hyperglycemia (HG) induces the demethylation of specific cytosines throughout the genome. We…”
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Inhibition of poly-ADP ribose polymerase enzyme activity prevents hyperglycemia-induced impairment of angiogenesis during wound healing by Sarras Jr, Michael P., Mason, Samantha, McAllister, Geoffrey, Intine, Robert V.

“…We previously reported a zebrafish model of type I diabetes mellitus (DM) that can be used to study the hyperglycemic (HG) and metabolic memory (MM) states…”
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Frequency of Gestational Diabetes Mellitus Reappearance or Absence during the Second Pregnancy of Women Treated at Mayo Clinic between 2013 and 2018 by Ruano, Rodrigo, Leontovich, Alexey A., Alrahmani, Layan, Egan, Aoife M., Enninga, Elizabeth Ann L., Sarras, Michael Peter

“…The Center for Disease Control and Prevention ranks diabetes mellitus (DM) as the seventh leading cause of death in the USA. The most prevalent forms of DM…”
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Inhibition of zebrafish fin regeneration using in vivo electroporation of morpholinos against fgfr1 and msxb by Thummel, Ryan, Bai, Shan, Sarras, Michael P., Song, Peizhen, McDermott, Jeffrey, Brewer, Jeffrey, Perry, Martin, Zhang, Xiaoming, Hyde, David R., Godwin, Alan R.

“…Increased interest in using zebrafish as a model organism has led to a resurgence of fin regeneration studies. This has allowed for the identification of a…”
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Impaired tissue regeneration corresponds with altered expression of developmental genes that persists in the metabolic memory state of diabetic zebrafish by Sarras Jr, Michael P., Leontovich, Alexey A., Olsen, Ansgar S., Intine, Robert V.

“…As previously reported by our laboratory, streptozocin‐induced diabetes mellitus (DM) in adult zebrafish results in an impairment of tissue regeneration as…”
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Epigenetic Studies Point to DNA Replication/Repair Genes as a Basis for the Heritable Nature of Long Term Complications in Diabetes by Leontovich, Alexey A., Sarras, Michael Peter, Intine, Robert V.

“…Metabolic memory (MM) is defined as the persistence of diabetic (DM) complications even after glycemic control is pharmacologically achieved. Using a zebrafish…”
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Use of zebrafish as a model to investigate the role of epigenetics in propagating the secondary complications observed in diabetes mellitus by Sarras, Michael P., Leontovich, Alexey A., Intine, Robert V.

“…Diabetes mellitus (DM) is classified as a disease of metabolic dysregulation predicted to affect over 400 million individuals world-wide by 2030. The…”
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The Collagens of Hydra Provide Insight into the Evolution of Metazoan Extracellular Matrices by Zhang, Xiaoming, Boot-Handford, Raymond P., Huxley-Jones, Julie, Forse, Lorna N., Mould, A. Paul, Robertson, David L., LiLi, Athiyal, Matthews, Sarras, Michael P.

“…A collagen-based extracellular matrix is one defining feature of all Metazoa. The thick sheet-like extracellular matrix (mesoglia) of the diploblast, hydra,…”
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In vivo imaging of basement membrane movement: ECM patterning shapes Hydra polyps by Aufschnaiter, Roland, Zamir, Evan A, Little, Charles D, Özbek, Suat, Münder, Sandra, David, Charles N, Li, Li, Sarras, Jr, Michael P, Zhang, Xiaoming

“…Growth and morphogenesis during embryonic development, asexual reproduction and regeneration require extensive remodeling of the extracellular matrix (ECM). We…”
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An assay for lateral line regeneration in adult zebrafish by Pisano, Gina C, Mason, Samantha M, Dhliwayo, Nyembezi, Intine, Robert V, Sarras, Jr, Michael P

“…Due to the clinical importance of hearing and balance disorders in man, model organisms such as the zebrafish have been used to study lateral line development…”
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Both Hoxc13 orthologs are functionally important for zebrafish tail fin regeneration by Thummel, Ryan, Ju, Mila, Sarras, Michael P. Jr, Godwin, Alan R

“…Hox genes are re-expressed during regeneration in many species. Given their important role in body plan development, it has been assumed, but not directly…”
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Epithelial morphogenesis in hydra requires de novo expression of extracellular matrix components and matrix metalloproteinases by Shimizu, Hiroshi, Zhang, Xiaoming, Zhang, Jinsong, Leontovich, Alexey, Fei, Kaiyin, Yan, Li, Sarras, Jr, Michael P

“…As a member of the phylum Cnidaria, the body wall of hydra is organized as an epithelium bilayer (ectoderm and endoderm) with an intervening extracellular…”
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Cre‐mediated site‐specific recombination in zebrafish embryos by Thummel, Ryan, Burket, Christopher T., Brewer, Jeffrey L., Sarras, Michael P., Li, Li, Perry, Martin, McDermott, Jeffrey P., Sauer, Brian, Hyde, David R., Godwin, Alan R.

“…Cre‐mediated site‐specific recombination has become an invaluable tool for manipulation of the murine genome. The ability to conditionally activate gene…”
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The extracellular matrix of hydra is a porous sheet and contains type IV collagen by Shimizu, Hiroshi, Aufschnaiter, Roland, Li, Li, Sarras, Michael P., Borza, Dorin-Bogdan, Abrahamson, Dale R., Sado, Yoshikazu, Zhang, Xiaoming

“…Hydra, as an early diploblastic metazoan, has a well-defined extracellular matrix (ECM) called mesoglea. It is organized in a tri-laminar pattern with one…”
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Matrix metalloproteinase expression and function during fin regeneration in zebrafish: Analysis of MT1-MMP, MMP2 and TIMP2 by Bai, Shan, Thummel, Ryan, Godwin, Alan R., Nagase, Hideaki, Itoh, Yoshifumi, Li, Li, Evans, Richard, McDermott, Jeffrey, Seiki, Motoharu, Sarras, Michael P.

“…Matrix metalloproteinases (MMPs) play key roles in the turnover of extracellular matrix (ECM) and, thereby, function as key regulators of cell-ECM interactions…”
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