Search Results - "Sarpong, Martha A"

Radical cyclization studies directed toward the synthesis of BMS-200475 ‘entecavir’: the carbocyclic core by Ziegler, Frederick E, Sarpong, Martha A

“…Two routes are presented for the conversion of d-diacetone glucose ( 5a ) into a protected carbocyclic core of BMS-200475 (Entecavir). The reduction of two…”
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Abstract C62: Identification of GSK2126458, a highly potent inhibitor of phosphoinositide 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR) by Knight, Steven D., Adams, Nicholas D., Burgess, Joelle L., Chaudhari, Amita M., Darcy, Michael G., Donatelli, Carla A., Newlander, Ken A., Parrish, Cynthia A., Ridgers, Lance H., Sarpong, Martha A., Schmidt, Stanley J., Van Aller, Glenn, Carson, Jeff D., Elkins, Patricia A., Diamond, Melody, Gardiner, Christine M., Garver, Eric, Luo, Lusong, Raha, Kaushik, Sung, Chiu-Mei, Tummino, Peter J., Auger, Kurt R., Dhanak, Dashyant

“…Abstract Phosphoinositide 3-kinase (PI3K) is a critical regulator of cell growth and transformation and its signaling pathway is one of the most commonly…”
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Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin by Knight, Steven D, Adams, Nicholas D, Burgess, Joelle L, Chaudhari, Amita M, Darcy, Michael G, Donatelli, Carla A, Luengo, Juan I, Newlander, Ken A, Parrish, Cynthia A, Ridgers, Lance H, Sarpong, Martha A, Schmidt, Stanley J, Van Aller, Glenn S, Carson, Jeffrey D, Diamond, Melody A, Elkins, Patricia A, Gardiner, Christine M, Garver, Eric, Gilbert, Seth A, Gontarek, Richard R, Jackson, Jeffrey R, Kershner, Kevin L, Luo, Lusong, Raha, Kaushik, Sherk, Christian S, Sung, Chiu-Mei, Sutton, David, Tummino, Peter J, Wegrzyn, Ronald J, Auger, Kurt R, Dhanak, Dashyant

“…Phosphoinositide 3-kinase α (PI3Kα) is a critical regulator of cell growth and transformation, and its signaling pathway is the most commonly mutated pathway…”
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Discovery of GSK1070916, a Potent and Selective Inhibitor of Aurora B/C Kinase by Adams, Nicholas D, Adams, Jerry L, Burgess, Joelle L, Chaudhari, Amita M, Copeland, Robert A, Donatelli, Carla A, Drewry, David H, Fisher, Kelly E, Hamajima, Toshihiro, Hardwicke, Mary Ann, Huffman, William F, Koretke-Brown, Kristin K, Lai, Zhihong V, McDonald, Octerloney B, Nakamura, Hiroko, Newlander, Ken A, Oleykowski, Catherine A, Parrish, Cynthia A, Patrick, Denis R, Plant, Ramona, Sarpong, Martha A, Sasaki, Kosuke, Schmidt, Stanley J, Silva, Domingos J, Sutton, David, Tang, Jun, Thompson, Christine S, Tummino, Peter J, Wang, Jamin C, Xiang, Hong, Yang, Jingsong, Dhanak, Dashyant

“…The Aurora kinases play critical roles in the regulation of mitosis and are frequently overexpressed or amplified in human tumors. Selective inhibitors may…”
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Abstract C74: Reassessing IKKε as a novel oncology target by Richter, Mark C., Groy, Arthur X., Wang, Da-Yuan, Lu, Quinn, Holbrook, Joanna D., Sarpong, Martha A., Seefeld, Mark A., Smith, Danielle M., Laquerre, Sylvie G., Gilmartin, Aidan G.

“…Abstract Recent years have seen increasing efforts to employ integrative genomic approaches to identify novel oncogenes. In this manner, IKBKE coding for IKKε…”
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Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin by Knight, Steven D., Adams, Nicholas D., Burgess, Joelle L., Chaudhari, Amita M., Darcy, Michael G., Donatelli, Carla A., Luengo, Juan I., Newlander, Ken A., Parrish, Cynthia A., Ridgers, Lance H., Sarpong, Martha A., Schmidt, Stanley J., Van Aller, Glenn S., Carson, Jeffrey D., Diamond, Melody A., Elkins, Patricia A., Gardiner, Christine M., Garver, Eric, Gilbert, Seth A., Gontarek, Richard R., Jackson, Jeffrey R., Kershner, Kevin L., Luo, Lusong, Raha, Kaushik, Sherk, Christian S., Sung, Chiu-Mei, Sutton, David, Tummino, Peter J., Wegrzyn, Ronald J., Auger, Kurt R., Dhanak, Dashyant

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