Search Results - "Sarparanta, Mirkka"

Multimodality Imaging of Silica and Silicon Materials In Vivo by Karaman, Didem Şen, Sarparanta, Mirkka P., Rosenholm, Jessica M., Airaksinen, Anu J.

“…Recent progress in the development of silica‐ and silicon‐based multimodality imaging nanoprobes has advanced their use in image‐guided drug delivery, and the…”
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Harnessing PET to track micro- and nanoplastics in vivo by Keinänen, Outi, Dayts, Eric J., Rodriguez, Cindy, Sarrett, Samantha M., Brennan, James M., Sarparanta, Mirkka, Zeglis, Brian M.

“…The proliferation of plastics in the environment continues at an alarming rate. Plastic particles have been found to be persistent and ubiquitous pollutants in…”
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Multifunctional porous silicon nanoparticles for cancer theranostics by Wang, Chang-Fang, Sarparanta, Mirkka P, Mäkilä, Ermei M, Hyvönen, Maija L.K, Laakkonen, Pirjo M, Salonen, Jarno J, Hirvonen, Jouni T, Airaksinen, Anu J, Santos, Hélder A

“…Abstract Nanomaterials provide a unique platform for the development of theranostic systems that combine diagnostic imaging modalities with a therapeutic…”
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“Invisible” radioactive cesium atoms revealed: Pollucite inclusion in cesium-rich microparticles (CsMPs) from the Fukushima Daiichi Nuclear Power Plant by Miyazaki, Kanako, Takehara, Masato, Minomo, Kenta, Horie, Kenji, Takehara, Mami, Yamasaki, Shinya, Saito, Takumi, Ohnuki, Toshihiko, Takano, Masahide, Shiotsu, Hiroyuki, Iwata, Hajime, Vettese, Gianni F., Sarparanta, Mirkka P., Law, Gareth T.W., Grambow, Bernd, Ewing, Rodney C., Utsunomiya, Satoshi

“…Understanding radioactive Cs contamination has been a central issue at Fukushima Daiichi and other nuclear legacy sites; however, atomic-scale characterization…”
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Towards New Delivery Agents for Boron Neutron Capture Therapy: Synthesis and In Vitro Evaluation of a Set of Fluorinated Carbohydrate Derivatives by Matović, Jelena, Järvinen, Juulia, Sokka, Iris K, Imlimthan, Surachet, Aitio, Olli, Sarparanta, Mirkka, Rautio, Jarkko, Ekholm, Filip S

“…Boron Neutron Capture Therapy (BNCT) is a cancer treatment which combines tumor-selective boron delivery agents with thermal neutrons in order to selectively…”
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Copper-free azide–alkyne cycloaddition of targeting peptides to porous silicon nanoparticles for intracellular drug uptake by Wang, Chang-Fang, Mäkilä, Ermei M, Kaasalainen, Martti H, Liu, Dongfei, Sarparanta, Mirkka P, Airaksinen, Anu J, Salonen, Jarno J, Hirvonen, Jouni T, Santos, Hélder A

“…Abstract Porous silicon (PSi) has been demonstrated as a promising drug delivery vector for poorly water-soluble drugs. Here, a simple and efficient method…”
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Evaluation of Organo [ 18 F]Fluorosilicon Tetrazine as a Prosthetic Group for the Synthesis of PET Radiotracers by Otaru, Sofia, Imlimthan, Surachet, Sarparanta, Mirkka, Helariutta, Kerttuli, Wähälä, Kristiina, Airaksinen, Anu J

“…Fluorine-18 is the most widely used positron emission tomography (PET) radionuclide currently in clinical application, due to its optimal nuclear properties…”
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The mucoadhesive and gastroretentive properties of hydrophobin-coated porous silicon nanoparticle oral drug delivery systems by Sarparanta, Mirkka P, Bimbo, Luis M, Mäkilä, Ermei M, Salonen, Jarno J, Laaksonen, Päivi H, Helariutta, A.M. Kerttuli, Linder, Markus B, Hirvonen, Jouni T, Laaksonen, Timo J, Santos, Hélder A, Airaksinen, Anu J

“…Abstract Impediments to intestinal absorption, such as poor solubility and instability in the variable conditions of the gastrointestinal (GI) tract plague…”
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Exploring the Biochemical Foundations of a Successful GLUT1-Targeting Strategy to BNCT: Chemical Synthesis and In Vitro Evaluation of the Entire Positional Isomer Library of ortho -Carboranylmethyl-Bearing Glucoconjugates by Matović, Jelena, Järvinen, Juulia, Sokka, Iris K, Imlimthan, Surachet, Raitanen, Jan-Erik, Montaser, Ahmed, Maaheimo, Hannu, Huttunen, Kristiina M, Peräniemi, Sirpa, Airaksinen, Anu J, Sarparanta, Mirkka, Johansson, Mikael P, Rautio, Jarkko, Ekholm, Filip S

“…Boron neutron capture therapy (BNCT) is a noninvasive binary therapeutic modality applicable to the treatment of cancers. While BNCT offers a tumor-targeting…”
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Quantitative analysis of electroporation-mediated intracellular delivery via bioorthogonal luminescent reaction by Wang, Shiqi, Shcherbii, Mariia V., Hirvonen, Sami-Pekka, Silvennoinen, Gudrun, Sarparanta, Mirkka, Santos, Hélder A.

“…Efficient intracellular delivery is crucial for biotherapeutics, such as proteins, oligonucleotides, and CRISPR/Cas9 gene-editing systems, to achieve their…”
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Pretargeted PET Imaging of trans-Cyclooctene-Modified Porous Silicon Nanoparticles by Keinänen, Outi, Mäkilä, Ermei M., Lindgren, Rici, Virtanen, Helena, Liljenbäck, Heidi, Oikonen, Vesa, Sarparanta, Mirkka, Molthoff, Carla, Windhorst, Albert D., Roivainen, Anne, Salonen, Jarno J., Airaksinen, Anu J.

“…Pretargeted positron emission tomography (PET) imaging based on bioorthogonal chemical reactions has proven its potential in immunoimaging. It may also have…”
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In Vivo Evaluation of Porous Silicon and Porous Silicon Solid Lipid Nanocomposites for Passive Targeting and Imaging by Kallinen, Annukka M, Sarparanta, Mirkka P, Liu, Dongfei, Mäkilä, Ermei M, Salonen, Jarno J, Hirvonen, Jouni T, Santos, Hélder A, Airaksinen, Anu J

“…The use of nanoparticle carriers for the sustained release of cytotoxic drugs in cancer therapy can result in fewer adverse effects and can thus be of great…”
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SPECT/CT imaging of hNIS-expression after intravenous delivery of an oncolytic adenovirus and 131I by Rajecki, Maria, Sarparanta, Mirkka, Hakkarainen, Tanja, Tenhunen, Mikko, Diaconu, Iulia, Kuhmonen, Venla, Kairemo, Kalevi, Kanerva, Anna, Airaksinen, Anu J, Hemminki, Akseli

“…Oncolytic adenoviruses can be engineered for better tumor selectivity, gene delivery and be armed for imaging and concentrating radionuclides into tumors for…”
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Targeted Radiotherapy for Prostate Cancer with an Oncolytic Adenovirus Coding for Human Sodium Iodide Symporter by HAKKARAINEN, Tanja, RAJECKI, Maria, SARPARANTA, Mirkka, TENHUNEN, Mikko, AIRAKSINEN, Anu J, DESMOND, Renée A, KAIREMO, Kalevi, HEMMINKI, Akseli

“…Purpose: Oncolytic adenoviruses are promising tools for cancer therapy. Although several clinical reports have indicated both safety and promising antitumor…”
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Pretargeting of internalizing trastuzumab and cetuximab with a 18F-tetrazine tracer in xenograft models by Keinänen, Outi, Fung, Kimberly, Pourat, Jacob, Jallinoja, Vilma, Vivier, Delphine, Pillarsetty, NagaVara Kishore, Airaksinen, Anu J., Lewis, Jason S., Zeglis, Brian M., Sarparanta, Mirkka

“…Background Pretargeting-based approaches are being investigated for radioimmunoimaging and therapy applications to reduce the effective radiation burden to the…”
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Development of a (+)RESCA-triaryl phosphine for in vitro radiolabeling using the Staudinger ligation by Biti, Anisa, Imlimthan, Surachet, Sarparanta, Mirkka

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Towards pretargeted PET imaging of Programmed Death Ligand 1 (PD-L1) with a gallium-68-labeled tris(hydroxypyridinone)-tetrazine by Centanni, Alessia, Hauken, Daniel, Imlimthan, Surachet, Keinänen, Outi, Sarparanta, Mirkka

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P-38 - Optimized synthesis of tri(hydroxypyridinone)-tetrazine and 68Ga-radiolabeling for bioorthogonal chemistry by Centanni, Alessia, Sirna, Katia, Otaru, Sofia, Keinaenen, Outi, Sarparanta, Mirkka

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Optimized synthesis of tri(hydroxypyridinone)-tetrazine and 68Ga-radiolabeling for bioorthogonal chemistry by Centanni, Alessia, Sirna, Katia, Otaru, Sofia, Keinaenen, Outi, Sarparanta, Mirkka

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P-181 - Optimized synthesis of tris(hydroxypyridinone)-tetrazine and 68Ga radiolabeling for bioorthogonal chemistry by Centanni, Alessia, Sirna, Katia, Otaru, Sofia, Keinaenen, Outi, Sarparanta, Mirkka

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