Effects of hypoglycemia on human brain activation measured with fMRI

Effects of hypoglycemia on human brain activation measured with fMRI

Functional magnetic resonance imaging (fMRI) was used to measure the effects of acute hypoglycemia caused by passive sensory stimulation on brain activation. Visual stimulation was used to generate blood-oxygen-level-dependent (BOLD) contrast, which was monitored during hyperinsulinemic hypoglycemic...

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Bibliographic Details
Published in:Magnetic resonance imaging Vol. 24; no. 6; pp. 693 - 697
Main Authors: Anderson, Adam W., Heptulla, Rubina A., Driesen, Naomi, Flanagan, Daniel, Goldberg, Philip A., Jones, Timothy W., Rife, Fran, Sarofin, Hedy, Tamborlane, William, Sherwin, Robert, Gore, John C.
Format: Journal Article
Language:English
Published: Netherlands Elsevier Inc 01-07-2006
Subjects:
Adult
Blood Glucose - metabolism
BOLD effect
Brain Mapping - methods
Chromatography, High Pressure Liquid
Epinephrine - blood
Functional MRI
Glucagon - blood
Humans
Hydrocortisone - blood
Hypoglycemia
Hypoglycemia - physiopathology
Insulin - blood
Magnetic Resonance Imaging
Norepinephrine - blood
Photic Stimulation
Radioimmunoassay
Visual cortex
Visual Cortex - physiopathology
BOLD effect
Visual cortex
Functional MRI
Hypoglycemia
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Summary:Functional magnetic resonance imaging (fMRI) was used to measure the effects of acute hypoglycemia caused by passive sensory stimulation on brain activation. Visual stimulation was used to generate blood-oxygen-level-dependent (BOLD) contrast, which was monitored during hyperinsulinemic hypoglycemic and euglycemic clamp studies. Hypoglycemia (50±1 mg glucose/dl) decreased the fMRI signal relative to euglycemia in 10 healthy human subjects: the fractional signal change was reduced by 28±12% ( P<.05). These changes were reversed when euglycemia was restored. These data provide a basis of comparison for studies that quantify hypoglycemia-related changes in fMRI activity during cognitive tasks based on visual stimuli and demonstrate that variations in blood glucose levels may modulate BOLD signals in the healthy brain.
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ISSN:0730-725X
1873-5894
DOI:10.1016/j.mri.2006.03.013