Search Results - "Sarnicola, Maria Lucia"
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Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells
Published in Immunity (Cambridge, Mass.) (15-11-2016)“…Tumor-infiltrating regulatory T lymphocytes (Treg) can suppress effector T cells specific for tumor antigens. Deeper molecular definitions of…”
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Human airway organoids and microplastic fibers: A new exposure model for emerging contaminants
Published in Environment international (01-05-2022)“…[Display omitted] •Inhalation of microplastics may lead to their inclusion in lung epithelium during repair phase.•Human airway organoids are a suitable model…”
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Tumor Extracellular Matrix Stiffness Promptly Modulates the Phenotype and Gene Expression of Infiltrating T Lymphocytes
Published in International journal of molecular sciences (30-05-2021)“…The immune system is a fine modulator of the tumor biology supporting or inhibiting its progression, growth, invasion and conveys the pharmacological treatment…”
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Cancer-related CD15/FUT4 overexpression decreases benefit to agents targeting EGFR or VEGF acting as a novel RAF-MEK-ERK kinase downstream regulator in metastatic colorectal cancer
Published in Journal of experimental & clinical cancer research (01-10-2015)“…Cancer-related immune antigens in the tumor microenvironment could represent an obstacle to agents targeting EGFR "cetuximab" or VEGF "bevacizumab" in…”
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Immunosuppressant Treatment in Rheumatic Musculoskeletal Diseases Does Not Inhibit Elicitation of Humoral Response to SARS-CoV-2 Infection and Preserves Effector Immune Cell Populations
Published in Frontiers in immunology (10-06-2022)“…COVID-19 has proven to be particularly serious and life-threatening for patients presenting with pre-existing pathologies. Patients affected by rheumatic…”
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Polycomb Bodies Detection in Murine Fibromuscular Stroma from Skin, Skeletal Muscles, and Aortic Tissues
Published in Methods in molecular biology (Clifton, N.J.) (2023)“…The regulation of chromatin structure depends on a dynamic, multiple mechanisms that modulate gene expression and constitute the epigenome. The Polycomb group…”
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Characterization of human CD4+EOMES+GzmK+ T‐cell subsets unveils an uncoupling of suppressive functions from IL‐10‐producing capacities
Published in European journal of immunology (01-04-2024)“…Human CD4+EOMES+ T cells are heterogeneous and contain Th1‐cells, Tr1‐cells, and CD4+CTL. Tr1‐ cells and non‐classical EOMES+ Th1‐cells displayed,…”
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Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ
Published in Nature communications (20-04-2021)“…Cancer is characterized by pervasive epigenetic alterations with enhancer dysfunction orchestrating the aberrant cancer transcriptional programs and…”
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Maturation signatures of conventional dendritic cell subtypes in COVID‐19 suggest direct viral sensing
Published in European journal of immunology (01-01-2022)“…Growing evidence suggests that conventional dendritic cells (cDCs) undergo aberrant maturation in COVID‐19, which negatively affects T‐cell activation. The…”
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Clonally expanded EOMES+ Tr1-like cells in primary and metastatic tumors are associated with disease progression
Published in Nature immunology (01-06-2021)“…Regulatory T (T reg ) cells are a barrier for tumor immunity and a target for immunotherapy. Using single-cell transcriptomics, we found that CD4 + T cells…”
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SARS-COV-2 specific t-cells in patients with thyroid disorders related to COVID-19 are enriched in the thyroid and acquire a tissue-resident memory phenotype
Published in Clinical immunology (Orlando, Fla.) (01-09-2023)“…SARS-CoV-2 infections have been associated with the onset of thyroid disorders like classic subacute thyroiditis (SAT) or atypical SAT upon severe COVID…”
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Tracking the immune response profiles elicited by the BNT162b2 vaccine in COVID-19 unexperienced and experienced individuals
Published in Clinical immunology (Orlando, Fla.) (01-04-2024)“…Multiple vaccines have been approved to control COVID-19 pandemic, with Pfizer/BioNTech (BNT162b2) being widely used. We conducted a longitudinal analysis of…”
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Prognostic and predictive significance of CD15 and neutrophil/lymphocyte ratio (NLR) in metastatic colorectal cancer (mCRC) patients (pts) undergoing to first-line chemotherapy (CT)
Published in Journal of clinical oncology (20-05-2014)“…Abstract only…”
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