Search Results - "Sarnaik, Amod A."

Tumor-infiltrating lymphocyte treatment for anti-PD-1-resistant metastatic lung cancer: a phase 1 trial by Creelan, Benjamin C., Wang, Chao, Teer, Jamie K., Toloza, Eric M., Yao, Jiqiang, Kim, Sungjune, Landin, Ana M., Mullinax, John E., Saller, James J., Saltos, Andreas N., Noyes, David R., Montoya, Leighann B., Curry, Wesley, Pilon-Thomas, Shari A., Chiappori, Alberto A., Tanvetyanon, Tawee, Kaye, Frederic J., Thompson, Zachary J., Yoder, Sean J., Fang, Bin, Koomen, John M., Sarnaik, Amod A., Chen, Dung-Tsa, Conejo-Garcia, Jose R., Haura, Eric B., Antonia, Scott J.

“…Adoptive cell therapy using tumor-infiltrating lymphocytes (TILs) has shown activity in melanoma, but has not been previously evaluated in metastatic non-small…”
Get full text

Safety, Efficacy, and Biomarkers of Nivolumab With Vaccine in Ipilimumab-Refractory or -Naive Melanoma by WEBER, Jeffrey S, RAGINI REINEY KUDCHADKAR, KROEGER, Jodi, EYSMANS, Cabell, SARNAIK, Amod A, ANN CHEN, Y, BIN YU, GALLENSTEIN, Donna, HORAK, Christine E, INZUNZA, H. David, XIUHUA ZHAO, MARTINEZ, Alberto J, WENSHI WANG, GIBNEY, Geoffrey

“…Nivolumab, a human immunoglobulin G4-blocking antibody against the T-cell programmed death-1 checkpoint protein, has activity against metastatic melanoma. Its…”
Get full text

Lifileucel, a Tumor-Infiltrating Lymphocyte Therapy, in Metastatic Melanoma by Sarnaik, Amod A, Hamid, Omid, Khushalani, Nikhil I, Lewis, Karl D, Medina, Theresa, Kluger, Harriet M, Thomas, Sajeve S, Domingo-Musibay, Evidio, Pavlick, Anna C, Whitman, Eric D, Martin-Algarra, Salvador, Corrie, Pippa, Curti, Brendan D, Oláh, Judit, Lutzky, Jose, Weber, Jeffrey S, Larkin, James M G, Shi, Wen, Takamura, Toshimi, Jagasia, Madan, Qin, Harry, Wu, Xiao, Chartier, Cecile, Graf Finckenstein, Friedrich, Fardis, Maria, Kirkwood, John M, Chesney, Jason A

“…Effective treatment options are limited for patients with advanced (metastatic or unresectable) melanoma who progress after immune checkpoint inhibitors and…”
Get full text

Single-cell Characterization of the Cellular Landscape of Acral Melanoma Identifies Novel Targets for Immunotherapy by Li, Jiannong, Smalley, Inna, Chen, Zhihua, Wu, Jheng-Yu, Phadke, Manali S, Teer, Jamie K, Nguyen, Thanh, Karreth, Florian A, Koomen, John M, Sarnaik, Amod A, Zager, Jonathan S, Khushalani, Nikhil I, Tarhini, Ahmad A, Sondak, Vernon K, Rodriguez, Paulo C, Messina, Jane L, Chen, Y Ann, Smalley, Keiran S M

“…Acral melanoma is a rare subtype of melanoma that arises on the non-hair-bearing skin of the palms, soles, and nail beds. In this study, we used single-cell…”
Get full text

T cell mediated immunity after combination therapy with intralesional PV-10 and blockade of the PD-1/PD-L1 pathway in a murine melanoma model by Liu, Hao, Weber, Amy, Morse, Jennifer, Kodumudi, Krithika, Scott, Ellen, Mullinax, John, Sarnaik, Amod A, Pilon-Thomas, Shari

“…Intralesional (IL) injection of Rose Bengal (PV-10) induces regression of injected and uninjected lesions in several murine tumor models. In this study, we…”
Get full text

Immune Checkpoint Blockade to Improve Tumor Infiltrating Lymphocytes for Adoptive Cell Therapy by Kodumudi, Krithika N, Siegel, Jessica, Weber, Amy M, Scott, Ellen, Sarnaik, Amod A, Pilon-Thomas, Shari

“…Tumor-infiltrating lymphocytes (TIL) has been associated with improved survival in cancer patients. Within the tumor microenvironment, regulatory cells and…”
Get full text

Intralesional injection of rose bengal induces a systemic tumor-specific immune response in murine models of melanoma and breast cancer by Toomey, Paul, Kodumudi, Krithika, Weber, Amy, Kuhn, Lisa, Moore, Ellen, Sarnaik, Amod A, Pilon-Thomas, Shari

“…Intralesional (IL) injection of PV-10 has shown to induce regression of both injected and non-injected lesions in patients with melanoma. To determine an…”
Get full text

Expansion of tumor-infiltrating lymphocytes (TIL) from human pancreatic tumors by Hall, MacLean, Liu, Hao, Malafa, Mokenge, Centeno, Barbara, Hodul, Pamela J., Pimiento, José, Pilon-Thomas, Shari, Sarnaik, Amod A.

“…BackgroundWe evaluated whether tumor infiltrating lymphocytes (TIL) could be expanded from surgically resected tumors from pancreatic cancer…”
Get full text

PTPN11 Plays Oncogenic Roles and Is a Therapeutic Target for BRAF Wild-Type Melanomas by Hill, Kristen S, Roberts, Evan R, Wang, Xue, Marin, Ellen, Park, Taeeun D, Son, Sorany, Ren, Yuan, Fang, Bin, Yoder, Sean, Kim, Sungjune, Wan, Lixin, Sarnaik, Amod A, Koomen, John M, Messina, Jane L, Teer, Jamie K, Kim, Youngchul, Wu, Jie, Chalfant, Charles E, Kim, Minjung

“…Melanoma is one of the most highly mutated cancer types. To identify functional drivers of melanoma, we searched for cross-species conserved mutations…”
Get full text

The HSP90 Inhibitor XL888 Overcomes BRAF Inhibitor Resistance Mediated through Diverse Mechanisms by PARAISO, Kim H. T, HAARBERG, H. Eirik, JOHN, Jobin K, SARNAIK, Amod A, KOOMEN, John M, SMALLEY, Keiran S. M, WOOD, Elizabeth, REBECCA, Vito W, CHEN, Y. Ann, YUN XIANG, RIBAS, Antoni, LO, Roger S, WEBER, Jeffrey S, SONDAK, Vernon K

“…The clinical use of BRAF inhibitors is being hampered by the acquisition of drug resistance. This study shows the potential therapeutic use of the HSP90…”
Get full text

Efficacy of Adoptive Cell Transfer of Tumor-infiltrating Lymphocytes After Lymphopenia Induction for Metastatic Melanoma by PILON-THOMAS, Shari, KUHN, Lisa, WEBER, Jeffrey, MULE, James J, SARNAIK, Amod A, ELLWANGER, Sabine, JANSSEN, William, ROYSTER, Erica, MARZBAN, Suroosh, KUDCHADKAR, Ragini, ZAGER, Jonathan, GIBNEY, Geoffrey, SONDAK, Vernon K

“…A single-institution pilot clinical trial was performed combining nonmyeloablative chemotherapy and the adoptive transfer of tumor-infiltrating lymphocytes…”
Get full text

Combination of Ipilimumab and Adoptive Cell Therapy with Tumor-Infiltrating Lymphocytes for Patients with Metastatic Melanoma by Mullinax, John E, Hall, MacLean, Prabhakaran, Sangeetha, Weber, Jeffrey, Khushalani, Nikhil, Eroglu, Zeynep, Brohl, Andrew S, Markowitz, Joseph, Royster, Erica, Richards, Allison, Stark, Valerie, Zager, Jonathan S, Kelley, Linda, Cox, Cheryl, Sondak, Vernon K, Mulé, James J, Pilon-Thomas, Shari, Sarnaik, Amod A

“…Adoptive cell therapy (ACT) using tumor-infiltrating lymphocytes (TIL) for metastatic melanoma can be highly effective, but attrition due to progression before…”
Get full text

Radar-Guided Localization and Resection for Metastatic Nodal and Soft Tissue Melanoma: A Single-Institution Retrospective Study by Beekman, Kate E, DePalo, Danielle K, Parker, Lily M, Elleson, Kelly M, Mullinax, John E, Sarnaik, Amod A, Sondak, Vernon K, Zager, Jonathan S

“…Radar-guided localization (RGL) offers a wire-free, nonradioactive surgical guidance method consisting of a small percutaneously-placed radar reflector and…”
Get full text

Intralesional injection of rose bengal augments the efficacy of gemcitabine chemotherapy against pancreatic tumors by Innamarato, Patrick, Morse, Jennifer, Mackay, Amy, Asby, Sarah, Beatty, Matthew, Blauvelt, Jamie, Kidd, Scott, Mullinax, John E, Sarnaik, Amod A, Pilon-Thomas, Shari

“…Chemotherapy regimens that include the utilization of gemcitabine are the standard of care in pancreatic cancer patients. However, most patients with advanced…”
Get full text

Biomarkers on melanoma patient T cells associated with ipilimumab treatment by Wang, Wenshi, Yu, Daohai, Sarnaik, Amod A, Yu, Bin, Hall, Maclean, Morelli, Dawn, Zhang, Yonghong, Zhao, Xiuhua, Weber, Jeffrey S

“…Ipilimumab induces long-lasting clinical responses in a minority of patients with metastatic melanoma. To better understand the mechanism(s) of action and to…”
Get full text

The Factors Affecting Expansion of Reactive Tumor Infiltrating Lymphocytes (TIL) From Bladder Cancer and Potential Therapeutic Applications by Aydin, Ahmet Murat, Bunch, Brittany L, Beatty, Matthew, Hajiran, Ali, Dhillon, Jasreman, Sarnaik, Amod A, Pilon-Thomas, Shari, Poch, Michael A

“…Tumor infiltrating lymphocytes (TIL) therapy was shown to provide durable objective response in patients with metastatic melanoma. As a fundamental first step…”
Get full text

Atypical Fibroxanthoma: Outcomes from a Large Single Institution Series by McClure, Erin, Carr, Michael J, Patel, Ayushi, Hussnain Naqvi, Syed Mahrukh, Kim, Youngchul, Harrington, Michael, Cruse, Wayne, Gonzalez, Ricardo J, Sondak, Vernon K, Sarnaik, Amod A, Messina, Jane L, Zager, Jonathan S

“…Background Atypical fibroxanthomas (AFX) are rare malignant cutaneous neoplasms. Unfortunately, limited clinicopathologic and outcomes data on this cancer…”
Get full text

Expansion of tumor infiltrating lymphocytes (TIL) from bladder cancer by Poch, Michael, Hall, MacLean, Joerger, Autumn, Kodumudi, Krithika, Beatty, Matthew, Innamarato, Pasquale P., Bunch, Brittany L., Fishman, Mayer N., Zhang, Jingsong, Sexton, Wade J., Pow-Sang, Julio M., Gilbert, Scott M., Spiess, Philippe E., Dhillon, Jasreman, Kelley, Linda, Mullinax, John, Sarnaik, Amod A, Pilon-Thomas, Shari

“…Advanced bladder cancer patients have limited therapeutic options resulting in a median overall survival (OS) between 12 and 15 months. Adoptive cell therapy…”
Get full text

Clinicopathologic predictors of survival in patients with desmoplastic melanoma by Han, Dale, Han, Gang, Zhao, Xiuhua, Rao, Nikhil G, Messina, Jane L, Marzban, Suroosh S, Sarnaik, Amod A, Cruse, C Wayne, Sondak, Vernon K, Zager, Jonathan S

“…Desmoplastic melanoma is a unique subtype of melanoma which typically affects older patients who often have comorbidities that can adversely affect survival…”
Get full text

Neoantigen-specific CD4+ tumor-infiltrating lymphocytes are potent effectors identified within adoptive cell therapy products for metastatic melanoma patients by Hall, MacLean S., Teer, Jamie K., Yu, Xiaoqing, Branthoover, Holly, Snedal, Sebastian, Rodriguez-Valentin, Madeline, Nagle, Luz, Scott, Ellen, Schachner, Ben, Innamarato, Patrick, Hall, Amy M., Blauvelt, Jamie, Rich, Carolyn J., Richards, Allison D., Ceccarelli, Jake, Langer, TJ, Yoder, Sean J., Beatty, Matthew S., Cox, Cheryl A., Messina, Jane L., Abate-Daga, Daniel, Mule, James J., Mullinax, John E., Sarnaik, Amod A., Pilon-Thomas, Shari

“…BackgroundAdoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TILs) is a promising immunotherapeutic approach for patients with advanced solid…”
Get full text