Evaluation of the relationship between xanthine oxidase activity and metabolic syndrome in a population group in Bangladesh

Evaluation of the relationship between xanthine oxidase activity and metabolic syndrome in a population group in Bangladesh

Xanthine oxidase (XO) is an enzyme that converts hypoxanthine into xanthine and xanthine into uric acid, which is then eliminated by the kidneys. Serum XO has been linked to diabetes, hypertension, liver dysfunction, and cardiovascular diseases. However, limited information exists on the relationshi...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports Vol. 14; no. 1; pp. 20380 - 9
Main Authors: Ali, Nurshad, Taher, Abu, Islam, Nayeemul, Sarna, Nusrat Zaman, Islam, Farjana
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 02-09-2024
Nature Publishing Group
Nature Portfolio
Subjects:
692/53
692/53/2421
692/53/2423
Adult
Association
Bangladesh - epidemiology
Bangladeshi adults
Blood glucose
Blood pressure
Cardiovascular diseases
Cholesterol
Colorimetry
Diabetes mellitus
Enzyme-linked immunosorbent assay
Enzymes
Female
High density lipoprotein
Humanities and Social Sciences
Humans
Hyperglycemia
Hypertension
Hypoxanthine
Liver diseases
Male
Metabolic disorders
Metabolic syndrome
Metabolic Syndrome - blood
Metabolic Syndrome - epidemiology
Middle Aged
multidisciplinary
Population studies
Regression analysis
Science
Science (multidisciplinary)
Uric acid
Xanthine oxidase
Xanthine Oxidase - blood
Xanthine Oxidase - metabolism
Bangladesh
Xanthine oxidase
Association
Metabolic syndrome
Bangladeshi adults
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Xanthine oxidase (XO) is an enzyme that converts hypoxanthine into xanthine and xanthine into uric acid, which is then eliminated by the kidneys. Serum XO has been linked to diabetes, hypertension, liver dysfunction, and cardiovascular diseases. However, limited information exists on the relationship between serum XO activity and MetS. This study aimed to analyze the relationship between XO activity and metabolic syndrome (MetS) and its components in an adult population group in Bangladesh A total of 601 participants aged ≥18 years were included in the study. MetS was defined based on the criteria set by the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III). Serum XO activity was measured using the enzyme-linked immunosorbent assay (ELISA), while other biochemical parameters were measured using colorimetric methods. The relationship between serum XO and MetS levels was determined through multivariate logistic regression analysis. S erum XO activity was found to be significantly higher in females (6.17 ± 3.77 U/L) as compared to males (4.00 ± 2.77 U/L) (p < 0.001). Furthermore, participants with MetS had significantly higher mean levels of serum XO (5.34 ± 3.39 U/L) than those without MetS (3.86 ± 2.90 U/L) (p < 0.001). The prevalence of MetS and its components, such as blood pressure and blood glucose increased across the XO quartiles (p < 0.001). Regression analysis indicated that XO activity was significantly and independently associated with the prevalence of MetS (at least p < 0.05 for all cases) and its components, including elevated blood pressure, high blood glucose, and low HDL-C (at least p < 0.05 for all cases). In conclusion, individuals with MetS had significantly higher XO levels than those without MetS. Serum XO activity showed an independent association with MetS and some of its components. Therefore, XO might serve as a useful marker of MetS. Prospective studies are needed to determine the underlying mechanisms linking XO and MetS.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-71733-4