Search Results - "Sarma, JVidya"

Role of extracellular histones in the cardiomyopathy of sepsis by Kalbitz, Miriam, Grailer, Jamison J., Fattahi, Fatemeh, Jajou, Lawrence, Herron, Todd J., Campbell, Katherine F., Zetoune, Firas S., Bosmann, Markus, Sarma, J. Vidya, Huber‐Lang, Markus, Gebhard, Florian, Loaiza, Randall, Valdivia, Hector H., Jalife, José, Russell, Mark W., Ward, Peter A.

“…ABSTRACT The purpose of this study was to define the relationship in polymicrobial sepsis (in adult male C57BL/6 mice) between heart dysfunction and the…”
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Complement Destabilizes Cardiomyocyte Function In Vivo after Polymicrobial Sepsis and In Vitro by Kalbitz, Miriam, Fattahi, Fatemeh, Herron, Todd J, Grailer, Jamison J, Jajou, Lawrence, Lu, Hope, Huber-Lang, Markus, Zetoune, Firas S, Sarma, J Vidya, Day, Sharlene M, Russell, Mark W, Jalife, José, Ward, Peter A

“…There is accumulating evidence during sepsis that cardiomyocyte (CM) homeostasis is compromised, resulting in cardiac dysfunction. An important role for…”
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Inhibition of junctional adhesion molecule-A/LFA interaction attenuates leukocyte trafficking and inflammation in brain ischemia/reperfusion injury by Sladojevic, Nikola, Stamatovic, Svetlana M, Keep, Richard F, Grailer, Jamison J, Sarma, J. Vidya, Ward, Peter A, Andjelkovic, Anuska V

“…Abstract Proinflammatory mediators trigger intensive postischemic inflammatory remodeling of the blood–brain barrier (BBB) including extensive brain…”
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Phagocyte-derived catecholamines enhance acute inflammatory injury by FLIERL, Michael A, RITTIRSCH, Daniel, HONGWEI GAO, VAN ROOIJEN, Nico, HUBER-LANG, Markus S, NEUBIG, Richard R, WARD, Peter A, NADEAU, Brian A, CHEN, Anthony J, SARMA, J. Vidya, ZETOUNE, Firas S, MCGUIRE, Stephanie R, LIST, Rachel P, DAY, Danielle E, HOESEL, L. Marco

“…It is becoming increasingly clear that the autonomic nervous system and the immune system demonstrate cross-talk during inflammation by means of sympathetic…”
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Changes and regulation of the C5a receptor on neutrophils during septic shock in humans by Unnewehr, Heike, Rittirsch, Daniel, Sarma, J Vidya, Zetoune, Firas, Flierl, Michael A, Perl, Mario, Denk, Stephanie, Weiss, Manfred, Schneider, Marion E, Monk, Peter N, Neff, Thomas, Mihlan, Michael, Barth, Holger, Gebhard, Florian, Ward, Peter A, Huber-Lang, Markus

“…During experimental sepsis, excessive generation of the anaphylatoxin C5a results in reduction of the C5a receptor (C5aR) on neutrophils. These events have…”
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Drusen Complement Components C3a and C5a Promote Choroidal Neovascularization by Nozaki, Miho, Raisler, Brian J., Sakurai, Eiji, Sarma, J. Vidya, Barnum, Scott R., Lambris, John D., Chen, Yali, Zhang, Kang, Ambati, Balamurali K., Baffi, Judit Z., Ambati, Jayakrishna

“…Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in industrialized nations, affecting 30-50 million people worldwide. The…”
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Interruption of macrophage-derived IL-27(p28) production by IL-10 during sepsis requires STAT3 but not SOCS3 by Bosmann, Markus, Russkamp, Norman F, Strobl, Birgit, Roewe, Julian, Balouzian, Liza, Pache, Florence, Radsak, Markus P, van Rooijen, Nico, Zetoune, Firas S, Sarma, J Vidya, Núñez, Gabriel, Müller, Mathias, Murray, Peter J, Ward, Peter A

“…Severe sepsis and septic shock are leading causes of morbidity and mortality worldwide. Infection-associated inflammation promotes the development and…”
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Complement activation product C5a is a selective suppressor of TLR4-induced, but not TLR3-induced, production of IL-27(p28) from macrophages by Bosmann, Markus, Haggadone, Mikel D, Hemmila, Mark R, Zetoune, Firas S, Sarma, J Vidya, Ward, Peter A

“…There is accumulating evidence that the complement activation product, C5a, can orchestrate cellular immune functions. IL-27(p28/EBI3) is an emerging key…”
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Complement dependency of cardiomyocyte release of mediators during sepsis by Atefi, Gelareh, Zetoune, Firas S., Herron, Todd J., Jalife, José, Bosmann, Markus, Al‐Aref, Rami, Sarma, J. Vidya, Ward, Peter A.

“…ABSTRACT We have recently shown that antibody‐induced blockade of C5a, C5a receptors, or IL‐17A greatly reduced the harmful outcomes of sepsis. In the current…”
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Acute Lung Injury Induced by Lipopolysaccharide Is Independent of Complement Activation by Rittirsch, Daniel, Flierl, Michael A, Day, Danielle E, Nadeau, Brian A, McGuire, Stephanie R, Hoesel, Laszlo M, Ipaktchi, Kyros, Zetoune, Firas S, Sarma, J. Vidya, Leng, Lin, Huber-Lang, Markus S, Neff, Thomas A, Bucala, Richard, Ward, Peter A

“…Although acute lung injury (ALI) is an important problem in humans, its pathogenesis is poorly understood. Airway instillation of bacterial LPS, a known…”
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An essential role for Stat3 in regulating IgG immune complex‐induced pulmonary inflammation by Tang, Huifang, Yan, Chunguang, Cao, Jay, Sarma, J. Vidya, Haura, Eric B., Wu, Min, Gao, Hongwei

“…ABSTRACT Growing evidence suggests that transcription factor signal transducer and activator of transcription (Stat) 3 may play an important regulatory role…”
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C5 deficiency and C5a or C5aR blockade protects against cerebral malaria by Patel, Samir N, Berghout, Joanne, Lovegrove, Fiona E, Ayi, Kodjo, Conroy, Andrea, Serghides, Lena, Min-oo, Gundula, Gowda, D Channe, Sarma, J Vidya, Rittirsch, Daniel, Ward, Peter A, Liles, W Conrad, Gros, Philippe, Kain, Kevin C

“…Experimental infection of mice with Plasmodium berghei ANKA (PbA) provides a powerful model to define genetic determinants that regulate the development of…”
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Regulatory role of C5a in LPS‐induced IL‐6 production by neutrophils during sepsis by Riedemann, Niels C., Guo, Ren‐Feng, Hollmann, Travis J., Gao, Hongwei, Neff, Thomas A., Reuben, Jayne S., Speyer, Cecilia L., Sarma, J. Vidya, Wetsel, Rick A., Zetoune, Firas S., Ward, Peter A.

“…Experimental sepsis in rodents occurring after cecal ligation/puncture (CLP) is associated with excessive complement activation and a systemic inflammatory…”
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An essential role for complement C5a in the pathogenesis of septic cardiac dysfunction by Niederbichler, Andreas D, Hoesel, Laszlo M, Westfall, Margaret V, Gao, Hongwei, Ipaktchi, Kyros R, Sun, Lei, Zetoune, Firas S, Su, Grace L, Arbabi, Saman, Sarma, J Vidya, Wang, Stewart C, Hemmila, Mark R, Ward, Peter A

“…Defective cardiac function during sepsis has been referred to as "cardiomyopathy of sepsis." It is known that sepsis leads to intensive activation of the…”
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The interaction between C 5a and both C 5a R and C 5 L 2 receptors is required for production of G ‐ CSF during acute inflammation by Bosmann, Markus, Haggadone, Mikel D., Zetoune, Firas S., Sarma, J. Vidya, Ward, Peter A.

“…The complement activation product, C 5a, is a key factor for regulation of inflammatory responses. C 5a and C 5a desArg bind to their receptors, C 5a R and C 5…”
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Regulatory effects of estrogen on acute lung inflammation in mice by Speyer, Cecilia L, Rancilio, Nicholas J, McClintock, Shannon D, Crawford, Jeffrey D, Gao, Hongwei, Sarma, J Vidya, Ward, Peter A

“…The role of estrogen in the regulation of the inflammatory response is not well defined. In this study, we investigated the effects of ovarian hormones on the…”
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Induction of M2 Regulatory Macrophages through the [beta]2-Adrenergic Receptor with Protection during Endotoxemia and Acute Lung Injury by Grailer, Jamison J, Haggadone, Mikel D, Sarma, J Vidya, Zetoune, Firas S, Ward, Peter A

“…The main drivers of acute inflammation are macrophages, which are known to have receptors for catecholamines. Based on their function, macrophages are broadly…”
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The complement anaphylatoxin C5a induces apoptosis in adrenomedullary cells during experimental sepsis by Flierl, Michael A, Rittirsch, Daniel, Chen, Anthony J, Nadeau, Brian A, Day, Danielle E, Sarma, J Vidya, Huber-Lang, Markus S, Ward, Peter A

“…Sepsis remains a poorly understood, enigmatic disease. One of the cascades crucially involved in its pathogenesis is the complement system. Especially the…”
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C5a-Blockade Improves Burn-Induced Cardiac Dysfunction by Hoesel, Laszlo M, Niederbichler, Andreas D, Schaefer, Julia, Ipaktchi, Kyros R, Gao, Hongwei, Rittirsch, Daniel, Pianko, Matthew J, Vogt, Peter M, Sarma, J. Vidya, Su, Grace L, Arbabi, Saman, Westfall, Margaret V, Wang, Stewart C, Hemmila, Mark R, Ward, Peter A

“…We previously reported that generation of the anaphylatoxin C5a is linked to the development of cardiac dysfunction in sepsis due to C5a interaction with its…”
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Adenoviral-Mediated Overexpression of SOCS3 Enhances IgG Immune Complex-Induced Acute Lung Injury by Gao, Hongwei, Hoesel, L. Marco, Guo, Ren-Feng, Rancilio, Nicholas J, Sarma, J. Vidya, Ward, Peter A

“…The lung inflammatory response caused by intratracheal deposition of IgG immune complexes (IC) includes the production of IL-6, which signals through…”
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