Search Results - "Sarma, Haladhar Dev"
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Design, synthesis and evaluation of 177Lu-labeled inverso and retro-inverso A9 peptide variants targeting HER2-overexpression
Published in Bioorganic chemistry (01-11-2023)“…[Display omitted] •‘Inverso’ and ‘retro inverso’ analogs of A9 peptide constructed.•Circular dichroism studies performed for ‘inverso’ and ‘retro inverso’…”
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Synthesis and comparative evaluation of 177Lu-labeled PEG and non-PEG variant peptides as HER2-targeting probes
Published in Scientific reports (20-09-2022)“…Highest global cancer incidence of female breast cancer is a matter of great concern. HER2-positive breast cancers have high mortality rate hence detection at…”
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Author Correction: Synthesis and comparative evaluation of 177Lu-labeled PEG and non-PEG variant peptides as HER2-targeting probes
Published in Scientific reports (08-11-2022)Get full text
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Radiosynthesis and Bioevaluation of [68Ga]-Labeled 5,10,15,20-Tetra(4-methylpyridyl)-porphyrin for Possible Application as a PET Radiotracer for Tumor Imaging
Published in Molecular imaging and biology (01-02-2015)“…Purpose Porphyrins have inherent ability to localize preferentially in tumor lesions. Cationic porphyrins are readily water soluble and reported to exhibit…”
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Comparative evaluation of heating ability and biocompatibility of different ferrite-based magnetic fluids for hyperthermia application
Published in Journal of biomedical materials research. Part B, Applied biomaterials (01-04-2007)“…In this study, lauric acid‐coated, superparamagnetic, nanoparticle‐based magnetic fluids of different ferrites (Fe3O4, MnFe2O4, and CoFe2O4) were prepared and…”
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Reactor produced [64Cu]CuCl2 as a PET radiopharmaceutical for cancer imaging: from radiochemistry laboratory to nuclear medicine clinic
Published in Annals of nuclear medicine (01-12-2020)“…Objective Copper-64 is a useful theranostic radioisotope that is attracting renewed interest from the nuclear medicine community in the recent times. This…”
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Flow synthesis of intrinsically radiolabeled and renal-clearable ultrasmall [198Au]Au nanoparticles in a PTFE microchannel
Published in Chemical engineering journal advances (15-05-2023)“…•Ultrasmall (< 5 nm diameter) 198Au[Au] NPs were synthesized in a microreactor.•Effect of different operating parameters on Au nanoparticle size were…”
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Synthesis and evaluation of 68Ga labeled palmitic acid for cardiac metabolic imaging
Published in Applied radiation and isotopes (01-10-2018)“…This work evaluates the potential of a 68Ga labeled long chain 16C fatty acid for cardiac metabolic imaging. For radiolabeling with 68Ga, hexadecanedioic acid…”
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68 Ga labeled fatty acids for cardiac metabolic imaging: Influence of different bifunctional chelators
Published in Bioorganic & medicinal chemistry letters (01-12-2016)“…Development of Ga labeled fatty acids is of immense interest due to the availability of Ga through a generator and its superiority over SPECT based tracers in…”
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Clinical scale synthesis of intrinsically radiolabeled and cyclic RGD peptide functionalized 198Au nanoparticles for targeted cancer therapy
Published in Nuclear medicine and biology (01-05-2019)“…The emerging concept of intrinsically radiolabeled nanoparticles has the potential to transform the preclinical and clinical studies by improving the in vivo…”
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99mTc carbonyl DTPA–Rituximab: Preparation and preliminary bioevaluation
Published in Applied radiation and isotopes (01-04-2014)“…The anti CD20 antibody Rituximab was conjugated with para isothiocyanato benzyl diethylene triamine penta acetic acid (p-NCS-Bz-DTPA) and subsequent…”
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Single vial freeze-dried TRODAT-1 kit: Preparation and demonstration of clinical efficacy of [99mTc]TRODAT-1 in Indian scenario
Published in Applied radiation and isotopes (01-02-2015)“…A single vial freeze-dried kit formulation for preparation of three patients׳ dose of [99mTc]TRODAT-1 has been developed for early diagnosis of Parkinson׳s…”
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Preparation of 99mTc carbonyl DTPA-bevacizumab and its bioevaluation in a melanoma model
Published in Annals of nuclear medicine (01-11-2014)“…Objective The objective of this study was to explore the potential of 99m Tc carbonyl labeled DTPA-bevacizumab as a tumor imaging agent. Bevacizumab (Avastin)…”
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Bioevaluation of (125) I Ocu-Prosta seeds for application in prostate cancer brachytherapy
Published in Indian journal of medical research (New Delhi, India : 1994) (01-04-2014)“…In recent years, brachytherapy involving permanent radioactive seed implantation has emerged as an effective modality for the management of cancer of prostate…”
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Synthesis and biological evaluation of 90Y-labeled porphyrin-DOTA conjugate: a potential molecule for targeted tumor therapy
Published in Cancer biotherapy & radiopharmaceuticals (01-11-2013)“…An unsymmetrically substituted porphyrin, 5-[4-(3-amino)-n-propyloxyphenyl]-10,15,20-tris-(4-carboxymethyleneoxyphenyl)porphyrin, was synthesized and coupled…”
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A novel 177Lu-labeled porphyrin for possible use in targeted tumor therapy
Published in Nuclear medicine and biology (01-07-2010)“…Porphyrin and its derivatives exhibit inherent affinity for localization in tumors. Hence, porphyrin derivatives radiolabeled with suitable therapeutic…”
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Preparation and preliminary bioevaluation of 99mTc(CO) 3-11β-progesterone derivative prepared via click chemistry route
Published in Nuclear medicine and biology (01-11-2010)“…Progesterone receptors (PRs) overexpressed in breast cancers serve as potential targets for developing radiotracers for use in nuclear medicine. Hence,…”
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Synthesis, characterization and biological activity of 99mTc-labeled piperidine analogues targeting sigma receptors
Published in Journal of labelled compounds & radiopharmaceuticals (01-04-2010)“…Sigma receptors are expressed in high density in various types of cancer cells including brain tumours and are also involved in various diseases of central…”
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Bioevaluation of (90)Y-labeled particles in animal model of arthritis
Published in Annals of nuclear medicine (01-06-2009)“…The aim of the present study was to evaluate the behaviour of (90)Y-labeled particles when injected into an arthritic knee joint of Wistar rats with severe…”
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