SUBCLINICAL INFLAMMATION IN NON/ALCOHOLIC FATTY LIVER DISEASE AT THE REMOTE PERIOD AFTER THE CHORNOBYL ACCIDENT

to evaluate the parameters of inflammatory reaction and oxidative stress in patients with non-alcoholicfatty liver disease (NAFLD) in the remote period after the influence of the Chornobyl accident factors. Eighty two patients with NAFLD who had been exposed to ionizing radiation as a result ofthe C...

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Published in:	Problemy radiatsiinoi medytsyny ta radiobiolohii Vol. 26; p. 437
Main Authors:	Nosach, O V, Sarkissova, E O, Alyokhina, S M, Pleskach, O Ya, Litvinets, O M, Ovsyannikova, L M, Chumak, A A
Format:	Journal Article
Language:	English
Published:	Ukraine 01-12-2021
Subjects:	Aged Cardiovascular Diseases - etiology Cardiovascular Diseases - physiopathology Chernobyl Nuclear Accident Emergency Responders - statistics & numerical data Humans Inflammation - epidemiology Inflammation - etiology Inflammation - physiopathology Male Middle Aged Non-alcoholic Fatty Liver Disease - epidemiology Non-alcoholic Fatty Liver Disease - physiopathology Radiation Dosage Radiation Exposure - adverse effects Radiation Injuries - epidemiology Radiation Injuries - etiology Radiation Injuries - physiopathology Radiation, Ionizing Radioactive Hazard Release Risk Assessment - statistics & numerical data Ukraine - epidemiology Ukraine non-alcoholic fatty liver disease Chornobyl accident chronic subclinical inflammation
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Summary:	to evaluate the parameters of inflammatory reaction and oxidative stress in patients with non-alcoholicfatty liver disease (NAFLD) in the remote period after the influence of the Chornobyl accident factors. Eighty two patients with NAFLD who had been exposed to ionizing radiation as a result ofthe Chornobyl accident and have concomitant cardiovascular pathology were examined. Hematological parametersand the level of highly sensitive C-reactive protein (hsCRP) were determined, and the content of products of oxida-tive modification of lipids and proteins was evaluated. Activation of the processes of oxidative modification of lipids and proteins was observed in most patientswith NAFLD. According to the level of hsCRP, the presence of subclinical inflammation and the risk of developingcomplicated cardiovascular pathology was found in 58 % of patients with NAFLD. The neutrophil / lymphocyte ratiocorrelates positively with hsCRP and can be used as an available routine clinical marker for selection among patientswith NAFLD persons with increased risk of cardiovascular complications. HsCRP, oxidative modification products of lipids and proteins, ESR, and leukograms should be used toassess the degree of systemic inflammation in people affected by the Chornobyl accident, suffering NAFLD with con-comitant cardiovascular disease.
ISSN:	2313-4607