Emblica officinalis improves glycemic status and oxidative stress in STZ induced type 2 diabetic model rats

To evaluate the antidiabetic and antioxidant potential of Emblica officinalis (E. officinalis) fruit on normal and type 2 diabetic rats. Type 2 diabetes was induced into the male Long-Evans rats. The rats were divided into nine groups including control groups receiving water, type 2 diabetic control...

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Bibliographic Details
Published in:	Asian Pacific journal of tropical medicine Vol. 7; no. 1; p. 21
Main Authors:	Ansari, Aneesa, Shahriar, Md Shahed Zaman, Hassan, Md Mehedi, Das, Shukla Rani, Rokeya, Begum, Haque, Md Anwarul, Haque, Md Enamul, Biswas, Nirupam, Sarkar, Tama
Format:	Journal Article
Language:	English
Published:	India 01-01-2014
Subjects:	Alanine Transaminase - blood Analysis of Variance Animals Antioxidants - pharmacology Antioxidants - therapeutic use Blood Glucose - drug effects Creatinine - blood Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Type 2 - drug therapy Glucose - metabolism Glutathione - blood Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use Insulin - blood Male Malondialdehyde - blood Oxidative Stress - drug effects Phyllanthus emblica - chemistry Plant Extracts - pharmacology Plant Extracts - therapeutic use Rats Rats, Long-Evans Reduced glutathione Type 2 diabetic rats Antioxidant Non-insulin dependent diabetes mellitus Emblica officinalis Antidiabetic
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Summary:	To evaluate the antidiabetic and antioxidant potential of Emblica officinalis (E. officinalis) fruit on normal and type 2 diabetic rats. Type 2 diabetes was induced into the male Long-Evans rats. The rats were divided into nine groups including control groups receiving water, type 2 diabetic controls, type 2 diabetic rats treated with glibenclamide (T2GT) and type 2 diabetic rats treated with aqueous extract of fruit pulp of E. officinalis. They were fed orally for 8 weeks with a single feeding. Blood was collected by cutting the tail tip on 0 and 28 days and by decapitation on 56 day. Packed red blood cells and serum were used for evaluating different biochemical parameters. Four weeks administration of aqueous extract of E. officinalis improved oral glucose tolerance in type 2 rats and after 8 weeks it caused significant (P<0.007) reduction in fasting serum glucose level compared to 0 day. Triglycerides decreased by 14% but there was no significant change in serum ALT, creatinine, cholesterol and insulin level in any group. Furthermore, reduced erythrocyte malondialdehyde level showed no significant change (P<0.07) but reduced glutathione content was found to be increased significantly (P<0.05). The aqueous extract of E. officinalis has a promising antidiabetic and antioxidant properties and may be considered for further clinical studies in drug development.
ISSN:	2352-4146
DOI:	10.1016/S1995-7645(13)60185-6