Search Results - "Sarkar, Riddhiman"

Impact of Magnetic Field Strength on Resolution and Sensitivity of Proton Resonances in Biological Solids by Xue, Kai, Sarkar, Riddhiman, Lalli, Daniela, Koch, Benita, Pintacuda, Guido, Tosner, Zdenek, Reif, Bernd

“…Sensitivity and resolution together determine the quality of NMR spectra in biological solids. Higher magic angle spinning frequencies yield a more efficient…”
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Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate by Rodriguez Camargo, Diana C, Korshavn, Kyle J, Jussupow, Alexander, Raltchev, Kolio, Goricanec, David, Fleisch, Markus, Sarkar, Riddhiman, Xue, Kai, Aichler, Michaela, Mettenleiter, Gabriele, Walch, Axel Karl, Camilloni, Carlo, Hagn, Franz, Reif, Bernd, Ramamoorthy, Ayyalusamy

“…Membrane-assisted amyloid formation is implicated in human diseases, and many of the aggregating species accelerate amyloid formation and induce cell death…”
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Mechanistic insights into the aggregation pathway of the patient-derived immunoglobulin light chain variable domain protein FOR005 by Pradhan, Tejaswini, Sarkar, Riddhiman, Meighen-Berger, Kevin M., Feige, Matthias J., Zacharias, Martin, Reif, Bernd

“…Systemic antibody light chain (AL) amyloidosis is characterized by deposition of amyloid fibrils. Prior to fibril formation, soluble oligomeric AL protein has…”
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Magic-Angle Spinning Frequencies beyond 300 kHz Are Necessary To Yield Maximum Sensitivity in Selectively Methyl Protonated Protein Samples in Solid-State NMR by Xue, Kai, Sarkar, Riddhiman, Motz, Carina, Asami, Sam, Decker, Venita, Wegner, Sebastian, Tosner, Zdenek, Reif, Bernd

“…In the last decade, proton detection in magic-angle spinning (MAS) solid-state NMR became a popular strategy for biomolecular structure determination. In…”
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Singlet-State Exchange NMR Spectroscopy for the Study of Very Slow Dynamic Processes by Sarkar, Riddhiman, Vasos, Paul R, Bodenhausen, Geoffrey

“…Singlet states with lifetimes that are longer than spin−lattice relaxation times T S ≫ T 1 offer unique opportunities for studying very slow dynamic processes…”
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Overcoming Volume Selectivity of Dipolar Recoupling in Biological Solid‐State NMR Spectroscopy by Tošner, Zdeněk, Sarkar, Riddhiman, Becker‐Baldus, Johanna, Glaubitz, Clemens, Wegner, Sebastian, Engelke, Frank, Glaser, Steffen J., Reif, Bernd

“…Dipolar recoupling in solid‐state NMR is an essential method for establishing correlations between nuclei that are close in space. In applications on protein…”
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MAK33 antibody light chain amyloid fibrils are similar to oligomeric precursors by Hora, Manuel, Sarkar, Riddhiman, Morris, Vanessa, Xue, Kai, Prade, Elke, Harding, Emma, Buchner, Johannes, Reif, Bernd

“…Little structural information is available so far on amyloid fibrils consisting of immunoglobulin light chains. It is not understood which features of the…”
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The redox environment triggers conformational changes and aggregation of hIAPP in Type II Diabetes by Rodriguez Camargo, Diana C., Tripsianes, Konstantinos, Buday, Katalin, Franko, Andras, Göbl, Christoph, Hartlmüller, Christoph, Sarkar, Riddhiman, Aichler, Michaela, Mettenleiter, Gabriele, Schulz, Michael, Böddrich, Annett, Erck, Christian, Martens, Henrik, Walch, Axel Karl, Madl, Tobias, Wanker, Erich E., Conrad, Marcus, de Angelis, Martin Hrabě, Reif, Bernd

“…Type II diabetes (T2D) is characterized by diminished insulin production and resistance of cells to insulin. Among others, endoplasmic reticulum (ER) stress is…”
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Manual and automatic assignment of two different Aβ40 amyloid fibril polymorphs using MAS solid-state NMR spectroscopy by Rodina, Natalia, Sarkar, Riddhiman, Tsakalos, Dimitrios, Suladze, Saba, Niu, Zheng, Reif, Bernd

“…Amyloid fibrils from Alzheimer’s amyloid-beta peptides (Aβ) are found to be polymorphic. So far, 14 Aβ40 fibril structures have been determined. The mechanism…”
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Limits of Resolution and Sensitivity of Proton Detected MAS Solid-State NMR Experiments at 111 kHz in Deuterated and Protonated Proteins by Xue, Kai, Sarkar, Riddhiman, Motz, Carina, Asami, Sam, Camargo, Diana C. Rodriguez, Decker, Venita, Wegner, Sebastian, Tosner, Zdenek, Reif, Bernd

“…MAS solid-state NMR is capable of determining structures of protonated solid proteins using proton-detected experiments. These experiments are performed at MAS…”
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Quantum rotation of ortho and para-water encapsulated in a fullerene cage by Beduz, Carlo, Carravetta, Marina, Chen, Judy Y.-C., Concistrè, Maria, Denning, Mark, Frunzi, Michael, Horsewill, Anthony J., Johannessen, Ole G., Lawler, Ronald, Lei, Xuegong, Levitt, Malcolm H., Li, Yongjun, Mamone, Salvatore, Murata, Yasujiro, Nagel, Urmas, Nishida, Tomoko, Ollivier, Jacques, Rols, Stéphane, Rõõm, Toomas, Sarkar, Riddhiman, Turro, Nicholas J., Yang, Yifeng

“…Inelastic neutron scattering, far-infrared spectroscopy, and cryogenic nuclear magnetic resonance are used to investigate the quantized rotation and ortho-para…”
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Diffusion Coefficients of Biomolecules Using Long-Lived Spin States by Ahuja, Puneet, Sarkar, Riddhiman, Vasos, Paul R, Bodenhausen, Geoffrey

“…We report the first observation of long-lived states (LLS) having lifetimes T LLS that exceed the corresponding spin−lattice relaxation times T 1 by more than…”
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Optimal control derived sensitivity-enhanced CA-CO mixing sequences for MAS solid-state NMR – Applications in sequential protein backbone assignments by Blahut, Jan, Brandl, Matthias J., Sarkar, Riddhiman, Reif, Bernd, Tošner, Zdeněk

“…•Optimal-control based pulses (TROP) enable homonuclear CA-CO transverse mixing.•Sensitivity-enhanced multidimensional experiments gain SNR by √2 per indirect…”
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Restoring Resolution in Biological Solid-State NMR under Conditions of Off-Magic-Angle Spinning by Sarkar, Riddhiman, Rodriguez Camargo, Diana C, Pintacuda, Guido, Reif, Bernd

“…Spin-state-selective excitation (S3E) experiments allow the selection of individual transitions in a coupled two spin system. We show that in the solid state,…”
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Proton NMR of 15N-Choline Metabolites Enhanced by Dynamic Nuclear Polarization by Sarkar, Riddhiman, Comment, Arnaud, Vasos, Paul R., Jannin, Sami, Gruetter, Rolf, Bodenhausen, Geoffrey, Hall, Hélène, Kirik, Deniz, Denisov, Vladimir P.

“…Chemical shifts of protons can report on metabolic transformations such as the conversion of choline to phosphocholine. To follow such processes in vivo,…”
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Solid state NMR assignments of a human λ-III immunoglobulin light chain amyloid fibril by Pradhan, Tejaswini, Annamalai, Karthikeyan, Sarkar, Riddhiman, Hegenbart, Ute, Schönland, Stefan, Fändrich, Marcus, Reif, Bernd

“…The aggregation of antibody light chains is linked to systemic light chain (AL) amyloidosis, a disease where amyloid deposits frequently affect the heart and…”
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Determination of methyl order parameters using solid state NMR under off magic angle spinning by Xue, Kai, Mamone, Salvatore, Koch, Benita, Sarkar, Riddhiman, Reif, Bernd

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SAA fibrils involved in AA amyloidosis are similar in bulk and by single particle reconstitution: A MAS solid-state NMR study by Sundaria, Arpita, Liberta, Falk, Savran, Dilan, Sarkar, Riddhiman, Rodina, Natalia, Peters, Carsten, Schwierz, Nadine, Haupt, Christian, Schmidt, Matthias, Reif, Bernd

“…[Display omitted] AA amyloidosis is one of the most prevalent forms of systemic amyloidosis and affects both humans and other vertebrates. In this study, we…”
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Long-Lived States to Monitor Protein Unfolding by Proton NMR by Bornet, Aurélien, Ahuja, Puneet, Sarkar, Riddhiman, Fernandes, Laetitia, Hadji, Sonia, Lee, Shirley Y., Haririnia, Aydin, Fushman, David, Bodenhausen, Geoffrey, Vasos, Paul R.

“…The relaxation of long‐lived states (LLS) corresponds to the slow return to statistical thermal equilibrium between symmetric and antisymmetric proton spin…”
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Extending the Scope of Singlet-State Spectroscopy by Sarkar, Riddhiman, Ahuja, Puneet, Moskau, Detlef, Vasos, Paul R., Bodenhausen, Geoffrey

“…Different decoupling sequences are tested—using various shaped radio‐frequency (RF) pulses—to achieve the longest possible lifetimes of singlet‐state…”
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