Search Results - "Sariyer, Ilker K."

Targeting CCR5 as a Component of an HIV-1 Therapeutic Strategy by Mohamed, Hager, Gurrola, Theodore, Berman, Rachel, Collins, Mackenzie, Sariyer, Ilker K, Nonnemacher, Michael R, Wigdahl, Brian

“…Globally, human immunodeficiency virus type 1 (HIV-1) infection is a major health burden for which successful therapeutic options are still being investigated…”
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Meta-Analysis of Methamphetamine Modulation on Amyloid Precursor Protein through HMGB1 in Alzheimer's Disease by Alabed, Sedra, Zhou, Heping, Sariyer, Ilker K, Chang, Sulie L

“…The deposition of amyloid-beta (Aβ) through the cleavage of amyloid-beta precursor protein (APP) is a biomarker of Alzheimer's disease (AD). This study used…”
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CRISPR based editing of SIV proviral DNA in ART treated non-human primates by Mancuso, Pietro, Chen, Chen, Kaminski, Rafal, Gordon, Jennifer, Liao, Shuren, Robinson, Jake A., Smith, Mandy D., Liu, Hong, Sariyer, Ilker K., Sariyer, Rahsan, Peterson, Tiffany A., Donadoni, Martina, Williams, Jaclyn B., Siddiqui, Summer, Bunnell, Bruce A., Ling, Binhua, MacLean, Andrew G., Burdo, Tricia H., Khalili, Kamel

“…Elimination of HIV DNA from infected individuals remains a challenge in medicine. Here, we demonstrate that intravenous inoculation of SIV-infected macaques, a…”
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Characterization of Nef expression in different brain regions of SIV-infected macaques by Yarandi, Shadan S, Robinson, Jake A, Vakili, Sarah, Donadoni, Martina, Burdo, Tricia H, Sariyer, Ilker K

“…HIV-associated CNS dysfunction is a significant problem among people with HIV (PWH), who now live longer due to viral suppression from combined anti-retroviral…”
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Coronavirus infection in chemosensory cells by Donadoni, Martina, Kaminski, Rafal, Liao, Shuren, Al Janabi, Suhair, Margolskee, Robert F., Ozdener, Mehmet Hakan, Sariyer, Ilker K.

“…Clinical manifestations of human coronavirus (HCoV)-related diseases are mostly related to the respiratory system, although secondary complications such as…”
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Off-Target Analysis in Gene Editing and Applications for Clinical Translation of CRISPR/Cas9 in HIV-1 Therapy by Atkins, Andrew, Chung, Cheng-Han, Allen, Alexander G, Dampier, Will, Gurrola, Theodore E, Sariyer, Ilker K, Nonnemacher, Michael R, Wigdahl, Brian

“…As genome-editing nucleases move toward broader clinical applications, the need to define the limits of their specificity and efficiency increases. A variety…”
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Delivering CRISPR to the HIV-1 reservoirs by Gurrola, Theodore E, Effah, Samuel N, Sariyer, Ilker K, Dampier, Will, Nonnemacher, Michael R, Wigdahl, Brian

“…Human immunodeficiency virus type 1 (HIV-1) infection is well known as one of the most complex and difficult viral infections to cure. The difficulty in…”
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Binge-Like Exposure to Ethanol Enhances Morphine's Anti-nociception in B6 Mice by Chang, Sulie L, Huang, Wenfei, Han, Haijun, Sariyer, Ilker K

“…Elevation of the blood ethanol concentration (BEC) to > 80 mg/dL (17.4 mM) after binge drinking enhances inflammation in brain and neuroimmune signaling…”
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Diagnostic assays for polyomavirus JC and progressive multifocal leukoencephalopathy by White, Martyn K., Sariyer, Ilker K., Gordon, Jennifer, Delbue, Serena, Pietropaolo, Valeria, Berger, Joseph R., Khalili, Kamel

“…Summary Progressive multifocal leukoencephalopathy (PML) is a devastating and often fatal demyelinating disease of the central nervous system for which…”
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Molecular and Cellular Impact of Inflammatory Extracellular Vesicles (EVs) Derived from M1 and M2 Macrophages on Neural Action Potentials by Vakili, Sarah, Ahooyi, Taha Mohseni, Yarandi, Shadan S, Donadoni, Martina, Rappaport, Jay, Sariyer, Ilker K

“…Several factors can contribute to neuroinflammatory disorders, such as cytokine and chemokines that are produced and released from peripherally derived immune…”
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Neurofibromatosis type 2 tumor suppressor protein, NF2, induces proteasome-mediated degradation of JC virus T-antigen in human glioblastoma by Beltrami, Sarah, Branchetti, Emanuela, Sariyer, Ilker K, Otte, Jessica, Weaver, Michael, Gordon, Jennifer

“…Neurofibromatosis type 2 protein (NF2) has been shown to act as tumor suppressor primarily through its functions as a cytoskeletal scaffold. However, NF2 can…”
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Infection by agnoprotein-negative mutants of polyomavirus JC and SV40 results in the release of virions that are mostly deficient in DNA content by Sariyer, Ilker K, Saribas, Abdullah S, White, Martyn K, Safak, Mahmut

“…Human polyomavirus JC (JCV) is the etiologic agent of a brain disease, known as progressive multifocal leukoencephalopathy (PML). The JCV genome encodes a…”
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iPSC-derived three-dimensional brain organoid models and neurotropic viral infections by Swingler, Michael, Donadoni, Martina, Bellizzi, Anna, Cakir, Senem, Sariyer, Ilker K.

“…Progress in stem cell research has revolutionized the medical field for more than two decades. More recently, the discovery of induced pluripotent stem cells…”
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Revisiting JC virus and progressive multifocal leukoencephalopathy by Rocchi, Angela, Sariyer, Ilker K., Berger, Joseph R.

“…Since its definition 65 years ago, progressive multifocal leukoencephalopathy (PML) has continued to devastate a growing population of immunosuppressed…”
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Modeling HIV-1 infection and NeuroHIV in hiPSCs-derived cerebral organoid cultures by Donadoni, Martina, Cakir, Senem, Bellizzi, Anna, Swingler, Michael, Sariyer, Ilker K.

“…The human immunodeficiency virus (HIV) epidemic is an ongoing global health problem affecting 38 million people worldwide with nearly 1.6 million new…”
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Neural Crest Cells Isolated from the Bone Marrow of Transgenic Mice Express JCV T-Antigen by Gordon, Jennifer, Sariyer, Ilker K, De La Fuente-Granada, Marisol, Augelli, Brian J, Otte, Jessica, Azizi, S Ausim, Amini, Shohreh, Khalili, Kamel, Krynska, Barbara

“…JC virus (JCV), a common human polyomavirus, is the etiological agent of the demyelinating disease, progressive multifocal leukoencephalopathy (PML). In…”
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Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice by Dash, Prasanta K., Kaminski, Rafal, Bella, Ramona, Su, Hang, Mathews, Saumi, Ahooyi, Taha M., Chen, Chen, Mancuso, Pietro, Sariyer, Rahsan, Ferrante, Pasquale, Donadoni, Martina, Robinson, Jake A., Sillman, Brady, Lin, Zhiyi, Hilaire, James R., Banoub, Mary, Elango, Monalisha, Gautam, Nagsen, Mosley, R. Lee, Poluektova, Larisa Y., McMillan, JoEllyn, Bade, Aditya N., Gorantla, Santhi, Sariyer, Ilker K., Burdo, Tricia H., Young, Won-Bin, Amini, Shohreh, Gordon, Jennifer, Jacobson, Jeffrey M., Edagwa, Benson, Khalili, Kamel, Gendelman, Howard E.

“…Elimination of HIV-1 requires clearance and removal of integrated proviral DNA from infected cells and tissues. Here, sequential long-acting slow-effective…”
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Phosphorylation Mutants of JC Virus Agnoprotein Are Unable To Sustain the Viral Infection Cycle by SARIYER, Ilker K, AKAN, Ilhan, PALERMO, Victoria, GORDON, Jennifer, KHALILI, Kamel, SAFAK, Mahmut

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Preclinical safety and biodistribution of CRISPR targeting SIV in non-human primates by Burdo, Tricia H., Chen, Chen, Kaminski, Rafal, Sariyer, Ilker K., Mancuso, Pietro, Donadoni, Martina, Smith, Mandy D., Sariyer, Rahsan, Caocci, Maurizio, Liao, Shuren, Liu, Hong, Huo, Wenwen, Zhao, Huaqing, Misamore, John, Lewis, Mark G., Simonyan, Vahan, Thompson, Elaine E., Xu, Ethan Y., Cradick, Thomas J., Gordon, Jennifer, Khalili, Kamel

“…In this study, we demonstrate the safety and utility of CRISPR-Cas9 gene editing technology for in vivo editing of proviral DNA in ART-treated, virally…”
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Emerging Role of Nef in the Development of HIV Associated Neurological Disorders by Yarandi, Shadan S, Duggan, Michael R, Sariyer, Ilker K

“…Despite adherence to treatment, individuals living with HIV have an increased risk for developing cognitive impairments, referred to as HIV-associated…”
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