DNA Protective, Aldose Reductase Inhibitory and Anti-Cataract Activities of Ferulic Acid

The current study assessed Ferulic acid’s DNA protective, aldose reductase inhibitory and anti- cataract activities. Different concentrations of ferulic acid are examined for DNA protection and incubated with aldose reductase isolated from a goat lens. Ferulic acid demonstrates a strong inhibitory e...

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Bibliographic Details
Published in:	Toxicology international pp. 515 - 522
Main Authors:	Bandaru, Nagaraju, Pedapati, Veera Mani Deepika, Sarika, Matta, Swaroopa, Suggu Vangmai, Aparna, M., Ibrahim, Md. Said, Gambhire, Makarand Suresh, Samineni, Ramu, Narender, M., Dudhe, Prashik B.
Format:	Journal Article
Language:	English
Published:	23-08-2024
Online Access:	Get full text
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Summary:	The current study assessed Ferulic acid’s DNA protective, aldose reductase inhibitory and anti- cataract activities. Different concentrations of ferulic acid are examined for DNA protection and incubated with aldose reductase isolated from a goat lens. Ferulic acid demonstrates a strong inhibitory effect against aldose reductase enzyme with IC50 value of 1.43 g/ mL and shows potent DNA protective action at the dose of 100 ug/mL against Fenton’s reagent induced DNA damage. Ferulic acid also reduces the formation of opacification in goat lens that inhibits the development of cataract and increases antioxidants levels significantly in lenses. This indicated that Ferulic acid inhibits the oxidative stress induced cataract. Based on the findings, Ferulic acid may be an effective option for the treatment of high glucose-induced cataract.
ISSN:	0971-6580 0976-5131
DOI:	10.18311/ti/2024/v31i4/43004