Search Results - "Saric, Tomo"

Myeloperoxidase Mediates Postischemic Arrhythmogenic Ventricular Remodeling by Mollenhauer, Martin, Friedrichs, Kai, Lange, Max, Gesenberg, Jan, Remane, Lisa, Kerkenpaß, Christina, Krause, Jenny, Schneider, Johanna, Ravekes, Thorben, Maass, Martina, Halbach, Marcel, Peinkofer, Gabriel, Saric, Tomo, Mehrkens, Dennis, Adam, Matti, Deuschl, Florian G, Lau, Denise, Geertz, Birgit, Manchanda, Kashish, Eschenhagen, Thomas, Kubala, Lukas, Rudolph, Tanja K, Wu, Yuping, Tang, W H Wilson, Hazen, Stanley L, Baldus, Stephan, Klinke, Anna, Rudolph, Volker

“…Ventricular arrhythmias remain the leading cause of death in patients suffering myocardial ischemia. Myeloperoxidase, a heme enzyme released by…”
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Preparation of cardiac extracellular matrix scaffolds by decellularization of human myocardium by Oberwallner, Barbara, Brodarac, Andreja, Choi, Yeong-Hoon, Saric, Tomo, Anić, Petra, Morawietz, Lars, Stamm, Christof

“…Extracellular matrix (ECM) derived by tissue decellularization has applications as a tissue engineering scaffold and for support of cellular regeneration…”
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The TMEM43 Newfoundland mutation p.S358L causing ARVC-5 was imported from Europe and increases the stiffness of the cell nucleus by Milting, Hendrik, Klauke, Bärbel, Christensen, Alex Hoerby, Müsebeck, Jörg, Walhorn, Volker, Grannemann, Sören, Münnich, Tamara, Šarić, Tomo, Rasmussen, Torsten Bloch, Jensen, Henrik Kjærulf, Mogensen, Jens, Baecker, Carolin, Romaker, Elena, Laser, Kai Thorsten, zu Knyphausen, Edzard, Kassner, Astrid, Gummert, Jan, Judge, Daniel P, Connors, Sean, Hodgkinson, Kathy, Young, Terry-L, van der Zwaag, Paul A, van Tintelen, J Peter, Anselmetti, Dario

“…Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare genetic condition caused predominantly by mutations within desmosomal genes. The mutation…”
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In vitro Modeling of Ryanodine Receptor 2 Dysfunction Using Human Induced Pluripotent Stem Cells by Fatima, Azra, Xu, Guoxing, Shao, Kaifeng, Papadopoulos, Symeon, Lehmann, Martin, Arnáiz-Cot, Juan J., Rosa, Angelo O., Nguemo, Filomain, Matzkies, Matthias, Dittmann, Sven, Stone, Susannah L., Linke, Matthias, Zechner, Ulrich, Beyer, Vera, Hennies, Hans Christian, Rosenkranz, Stephan, Klauke, Baerbel, Parwani, Abdul S., Haverkamp, Wilhelm, Pfitzer, Gabriele, Farr, Martin, Cleemann, Lars, Morad, Martin, Milting, Hendrik, Hescheler, Juergen, Šaric, Tomo

“…Background/Aims: Induced pluripotent stem (iPS) cells generated from accessible adult cells of patients with genetic diseases open unprecedented opportunities…”
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Stem cells-derived natural killer cells for cancer immunotherapy: current protocols, feasibility, and benefits of ex vivo generated natural killer cells in treatment of advanced solid tumors by Khodayari, Hamid, Khodayari, Saeed, Ebrahimi, Elmira, Hadjilooei, Farimah, Vesovic, Miko, Mahmoodzadeh, Habibollah, Saric, Tomo, Stücker, Wilfried, Van Gool, Stefaan, Hescheler, Jürgen, Nayernia, Karim

“…Nowadays, natural killer (NK) cell-based immunotherapy provides a practical therapeutic strategy for patients with advanced solid tumors (STs). This approach…”
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Persistence of intramyocardially transplanted murine induced pluripotent stem cell-derived cardiomyocytes from different developmental stages by Peinkofer, Gabriel, Maass, Martina, Pfannkuche, Kurt, Sachinidis, Agapios, Baldus, Stephan, Hescheler, Jürgen, Saric, Tomo, Halbach, Marcel

“…Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) are regarded as promising cell type for cardiac cell replacement therapy, but it is not known…”
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From Early Embryonic to Adult Stage: Comparative Study of Action Potentials of Native and Pluripotent Stem Cell-Derived Cardiomyocytes by Peinkofer, Gabriel, Burkert, Karsten, Urban, Katja, Krausgrill, Benjamin, Hescheler, Jürgen, Saric, Tomo, Halbach, Marcel

“…Cardiomyocytes (CMs) derived from induced pluripotent stem cells (iPS-CMs) are promising candidates for cell therapy, drug screening, and developmental…”
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Conversion of Human Fibroblasts to Stably Self-Renewing Neural Stem Cells with a Single Zinc-Finger Transcription Factor by Shahbazi, Ebrahim, Moradi, Sharif, Nemati, Shiva, Satarian, Leila, Basiri, Mohsen, Gourabi, Hamid, Zare Mehrjardi, Narges, Günther, Patrick, Lampert, Angelika, Händler, Kristian, Hatay, Firuze Fulya, Schmidt, Diana, Molcanyi, Marek, Hescheler, Jürgen, Schultze, Joachim L., Saric, Tomo, Baharvand, Hossein

“…Direct conversion of somatic cells into neural stem cells (NSCs) by defined factors holds great promise for mechanistic studies, drug screening, and potential…”
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Acquisition of chromosome 1q duplication in parental and genome‐edited human‐induced pluripotent stem cell‐derived neural stem cells results in their higher proliferation rate in vitro and in vivo by Mehrjardi, Narges Zare, Molcanyi, Marek, Hatay, Firuze Fulya, Timmer, Marco, Shahbazi, Ebrahim, Ackermann, Justus P., Herms, Stefan, Heilmann‐Heimbach, Stefanie, Wunderlich, Thomas F., Prochnow, Nora, Haghikia, Aiden, Lampert, Angelika, Hescheler, Jürgen, Neugebauer, Edmund A. M., Baharvand, Hossein, Šarić, Tomo

“…Objectives Genetic engineering of human‐induced pluripotent stem cell‐derived neural stem cells (hiPSC‐NSC) may increase the risk of genomic aberrations…”
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The Novel Desmin Mutant p.A120D Impairs Filament Formation, Prevents Intercalated Disk Localization, and Causes Sudden Cardiac Death by Brodehl, Andreas, Dieding, Mareike, Klauke, Bärbel, Dec, Eric, Madaan, Shrestha, Huang, Taosheng, Gargus, John, Fatima, Azra, Šaric, Tomo, Cakar, Hamdin, Walhorn, Volker, Tönsing, Katja, Skrzipczyk, Tim, Cebulla, Ramona, Gerdes, Désirée, Schulz, Uwe, Gummert, Jan, Svendsen, Jesper Hastrup, Olesen, Morten Salling, Anselmetti, Dario, Christensen, Alex Hørby, Kimonis, Virginia, Milting, Hendrik

“…BACKGROUND—The intermediate filament protein desmin is encoded by the gene DES and contributes to the mechanical stabilization of the striated muscle sarcomere…”
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The importance of the proteasome and subsequent proteolytic steps in the generation of antigenic peptides by Goldberg, Alfred L, Cascio, Paolo, Saric, Tomo, Rock, Kenneth L

“…Three different proteolytic processes have been shown to be important in the generation of antigenic peptides displayed on MHC-class I molecules. The great…”
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Decreased neural precursor cell pool in NADPH oxidase 2-deficiency: From mouse brain to neural differentiation of patient derived iPSC by Nayernia, Zeynab, Colaianna, Marilena, Robledinos-Antón, Natalia, Gutzwiller, Eveline, Sloan-Béna, Frédérique, Stathaki, Elisavet, Hibaoui, Yousef, Cuadrado, Antonio, Hescheler, Jürgen, Stasia, Marie-José, Saric, Tomo, Jaquet, Vincent, Krause, Karl-Heinz

“…There is emerging evidence for the involvement of reactive oxygen species (ROS) in the regulation of stem cells and cellular differentiation. Absence of the…”
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In Vitro Grown Micro-Tissues for Cardiac Cell Replacement Therapy in Vivo by Sahito, Raja Ghazanfar Ali, Sheng, Xiaowu, Maass, Martina, Mikhael, Nelly, Hamad, Sarkawt, Heras-Bautista, Carlos O, Derichsweiler, Daniel, Spitkovsky, Dimitry, Suhr, Frank, Khalil, Markus, Brockmeier, Konrad, Halbach, Marcel, Saric, Tomo, Hescheler, Jürgen, Krausgrill, Benjamin, Pfannkuche, Kurt

“…Different approaches have been considered to improve heart reconstructive medicine and direct delivery of pluripotent stem cell-derived cardiomyocytes…”
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CPAP promotes timely cilium disassembly to maintain neural progenitor pool by Gabriel, Elke, Wason, Arpit, Ramani, Anand, Gooi, Li Ming, Keller, Patrick, Pozniakovsky, Andrei, Poser, Ina, Noack, Florian, Telugu, Narasimha Swamy, Calegari, Federico, Šarić, Tomo, Hescheler, Jürgen, Hyman, Anthony A, Gottardo, Marco, Callaini, Giuliano, Alkuraya, Fowzan Sami, Gopalakrishnan, Jay

“…A mutation in the centrosomal‐P4.1‐associated protein (CPAP) causes Seckel syndrome with microcephaly, which is suggested to arise from a decline in neural…”
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Protein degradation and the generation of MHC class I-presented peptides by Rock, Kenneth L, York, Ian A, Saric, Tomo, Goldberg, Alfred L

“…Over the past decade there has been considerable progress in understanding how MHC class I-presented peptides are generated. The emerging theme is that the…”
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Epigenetic Rejuvenation of Mesenchymal Stromal Cells Derived from Induced Pluripotent Stem Cells by Frobel, Joana, Hemeda, Hatim, Lenz, Michael, Abagnale, Giulio, Joussen, Sylvia, Denecke, Bernd, Šarić, Tomo, Zenke, Martin, Wagner, Wolfgang

“…Standardization of mesenchymal stromal cells (MSCs) remains a major obstacle in regenerative medicine. Starting material and culture expansion affect cell…”
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The disease-specific phenotype in cardiomyocytes derived from induced pluripotent stem cells of two long QT syndrome type 3 patients by Fatima, Azra, Kaifeng, Shao, Dittmann, Sven, Xu, Guoxing, Gupta, Manoj K, Linke, Matthias, Zechner, Ulrich, Nguemo, Filomain, Milting, Hendrik, Farr, Martin, Hescheler, Jürgen, Sarić, Tomo

“…Long QT syndromes (LQTS) are heritable diseases characterized by prolongation of the QT interval on an electrocardiogram, which often leads to syncope and…”
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Research and therapy with induced pluripotent stem cells (iPSCs): social, legal, and ethical considerations by Moradi, Sharif, Mahdizadeh, Hamid, Šarić, Tomo, Kim, Johnny, Harati, Javad, Shahsavarani, Hosein, Greber, Boris, Moore, 4th, Joseph B

“…Induced pluripotent stem cells (iPSCs) can self-renew indefinitely in culture and differentiate into all specialized cell types including gametes. iPSCs do not…”
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The Cytosolic Endopeptidase, Thimet Oligopeptidase, Destroys Antigenic Peptides and Limits the Extent of MHC Class I Antigen Presentation by York, Ian A., Mo, Annie X.Y., Lemerise, Kristen, Zeng, Wanyong, Shen, Yuelei, Abraham, Carmela R., Saric, Tomo, Goldberg, Alfred L., Rock, Kenneth L.

“…Most antigenic peptides presented on MHC class I molecules are generated by proteasomes during protein breakdown. It is unknown whether these peptides are…”
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Regulation of the multidrug resistance transporter P‐glycoprotein in multicellular prostate tumor spheroids by hyperthermia and reactive oxygen species by Wartenberg, Maria, Gronczynska, Sabina, Bekhite, Mohamed M., Saric, Tomo, Niedermeier, Wilhelm, Hescheler, Jürgen, Sauer, Heinrich

“…Hyperthermia is an important component of many cancer treatment protocols. In our study the regulation of the multidrug resistance (MDR) transporter…”
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