Search Results - "Sari, Ozkan"

Synthesis and antiviral evaluation of 2′,2′,3′,3′-tetrafluoro nucleoside analogs by Sari, Ozkan, Bassit, Leda, Gavegnano, Christina, McBrayer, Tamara R., McCormick, Louise, Cox, Bryan, Coats, Steven J., Amblard, Franck, Schinazi, Raymond F.

“…[Display omitted] •The synthesis of novel 2′,2′,3′,3′-tetrafluoro nucleoside analogs is described.•Glycosylation reactions are achieved via Mitsunobu…”
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The Preparation of Trisubstituted Alkenyl Nucleoside Phosphonates under Ultrasound-Assisted Olefin Cross-Metathesis by Sari, Ozkan, Hamada, Manabu, Roy, Vincent, Nolan, Steven P, Agrofoglio, Luigi A

“…Intermolecular ultrasound-assisted olefin cross-metathesis is reported. This approach allows an easy access to challenging trisubstituted alkenyl nucleoside…”
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Diastereoselective Synthesis of 2′-Dihalopyrimidine Ribonucleoside Inhibitors of Hepatitis C Virus Replication by Zhou, Longhu, Zhang, Hongwang, Li, Chengwei, De Schutter, Coralie, Sari, Ozkan, Mengshetti, Seema, Zhou, Shaoman, Kasthuri, Mahesh, Coats, Steven J, Schinazi, Raymond F, Amblard, Franck

“…We present a newly developed synthetic route to 2-bromo-2-fluoro ribolactone based on our published 2-chloro-2-fluoro ribolactone synthesis. Stereoselective…”
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Novel Hepatitis B Virus Capsid Assembly Modulator Induces Potent Antiviral Responses In Vitro and in Humanized Mice by Amblard, Franck, Boucle, Sebastien, Bassit, Leda, Cox, Bryan, Sari, Ozkan, Tao, Sijia, Chen, Zhe, Ozturk, Tugba, Verma, Kiran, Russell, Olivia, Rat, Virgile, de Rocquigny, Hugues, Fiquet, Oriane, Boussand, Maud, Di Santo, James, Strick-Marchand, Helene, Schinazi, Raymond F

“…Hepatitis B virus (HBV) affects an estimated 250 million chronic carriers worldwide. Though several vaccines exist, they are ineffective for those already…”
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Synthesis of sulfamoylbenzamide derivatives as HBV capsid assembly effector by Sari, Ozkan, Boucle, Sebastien, Cox, Bryan D., Ozturk, Tugba, Russell, Olivia Ollinger, Bassit, Leda, Amblard, Franck, Schinazi, Raymond F.

“…The synthesis of novel series of sulfamoylbenzamides as HBV capsid assembly effector is reported. The structure was divided into five parts which were…”
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Discovery and structure activity relationship of glyoxamide derivatives as anti-hepatitis B virus agents by Amblard, Franck, Boucle, Sebastien, Bassit, Leda, Chen, Zhe, Sari, Ozkan, Cox, Bryan, Verma, Kiran, Ozturk, Tugba, Ollinger-Russell, Olivia, Schinazi, Raymond F.

“…[Display omitted] Chronic hepatitis B viral infection is a significant health problem world-wide, and currently available antiviral agents suppress HBV…”
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Synthesis of (2S)‑2-Chloro-2-fluororibolactone via Stereoselective Electrophilic Fluorination by De Schutter, Coralie, Sari, Ozkan, Coats, Steven J, Amblard, Franck, Schinazi, Raymond F

“…A novel and efficient route for the preparation of (2S)-2-chloro-2-fluorolactone 29 is described. This approach takes advantage of a highly efficient…”
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Erratum for Amblard et al., “Novel Hepatitis B Virus Capsid Assembly Modulator Induces Potent Antiviral Responses In Vitro and in Humanized Mice” by Amblard, Franck, Boucle, Sebastien, Bassit, Leda, Cox, Bryan, Sari, Ozkan, Tao, Sijia, Chen, Zhe, Ozturk, Tugba, Verma, Kiran, Russell, Olivia, Rat, Virgile, de Rocquigny, Hugues, Fiquet, Oriane, Boussand, Maud, Di Santo, James, Strick-Marchand, Helene, Schinazi, Raymond F

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2′-Chloro,2′-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture by Zhou, Shaoman, Mahmoud, Sawsan, Liu, Peng, Zhou, Longhu, Ehteshami, Maryam, Bassit, Leda, Tao, Sijia, Domaoal, Robert A, Sari, Ozkan, Schutter, Coralie De, Amiralaei, Sheida, Khalil, Ahmed, Ollinger Russell, Olivia, McBrayer, Tamara, Whitaker, Tony, Abou-Taleb, Nageh, Amblard, Franck, Coats, Steven J, Schinazi, Raymond F

“…Pan-genotypic nucleoside HCV inhibitors display a high genetic barrier to drug resistance and are the preferred direct-acting agents to achieve complete…”
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Synthesis of dihydropyrimidine α,γ-diketobutanoic acid derivatives targeting HIV integrase by Sari, Ozkan, Roy, Vincent, Métifiot, Mathieu, Marchand, Christophe, Pommier, Yves, Bourg, Stéphane, Bonnet, Pascal, Schinazi, Raymond F., Agrofoglio, Luigi A.

“…The synthesis and antiviral evaluation of a series of dihydropyrimidinone and thiopyrimidine derivatives bearing aryl α,γ-diketobutanoic acid moiety are…”
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Discovery of a Series of 2′-α-Fluoro,2′-β-bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus by Mengshetti, Seema, Zhou, Longhu, Sari, Ozkan, De Schutter, Coralie, Zhang, Hongwang, Cho, Jong Hyun, Tao, Sijia, Bassit, Leda C, Verma, Kiran, Domaoal, Robert A, Ehteshami, Maryam, Jiang, Yong, Ovadia, Reuben, Kasthuri, Mahesh, Ollinger Russell, Olivia, McBrayer, Tamara, Whitaker, Tony, Pattassery, Judy, Pascual, Maria Luz, Uher, Lothar, Lin, Biing Y, Lee, Sam, Amblard, Franck, Coats, Steven J, Schinazi, Raymond F

“…Hepatitis C virus (HCV) nucleoside inhibitors display pan-genotypic activity, a high barrier to the selection of resistant virus, and are some of the most…”
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Synthesis and antiviral evaluation of C5-substituted-(1,3-diyne)-2′-deoxyuridines by Sari, Ozkan, Roy, Vincent, Balzarini, Jan, Snoeck, Robert, Andrei, Graciela, Agrofoglio, Luigi A.

“…Starting from acetylated 5-ethynyl-2′-deoxyuridine (3), 14 hitherto unknown C5-substituted-(1,3-diyne)-2′-deoxyuridines (with cyclopropyl, hydroxymethyl,…”
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Synthesis and antiviral evaluation of bis(POM) prodrugs of (E)-[4′-phosphono-but-2′-en-1′-yl]purine nucleosides by Pradère, Ugo, Roy, Vincent, Montagu, Aurélien, Sari, Ozkan, Hamada, Manabu, Balzarini, Jan, Snoeck, Robert, Andrei, Graciela, Agrofoglio, Luigi A.

“…Seventeen hitherto unknown bis(POM) prodrugs of novel (E)-[4′-phosphono-but-2′-en-1′-yl]purine nucleosides were prepared in a straight approach and at good…”
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Sonication‐Assisted Synthesis of (E)‐2‐Methyl‐but‐2‐enyl Nucleoside Phosphonate Prodrugs by Bessières, Maxime, Sari, Ozkan, Roy, Vincent, Warszycki, Dawid, Bojarski, Andrzej J., Nolan, Steven P., Snoeck, Robert, Andrei, Graciela, Schinazi, Raymond F., Agrofoglio, Luigi A.

“…Several hitherto unknown acyclic 2‐methyl‐but‐2‐enyl nucleoside phosphonate analogs (ANPs) and their bis‐(pivaloyloxymethyl) prodrug forms were prepared by a…”
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