Search Results - "Sarhan, Mona O"

Discovery of New Coumarin-Based Lead with Potential Anticancer, CDK4 Inhibition and Selective Radiotheranostic Effect: Synthesis, 2D & 3D QSAR , Molecular Dynamics, In Vitro Cytotoxicity, Radioiodination, and Biodistribution Studies by Sarhan, Mona O, Abd El-Karim, Somaia S, Anwar, Manal M, Gouda, Raghda H, Zaghary, Wafaa A, Khedr, Mohammed A

“…Novel 6-bromo-coumarin-ethylidene-hydrazonyl-thiazolyl and 6-bromo-coumarin-thiazolyl-based derivatives were synthesized. A quantitative structure activity…”
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Dynamic PET reveals compartmentalized brain and lung tissue antibiotic exposures of tuberculosis drugs by Chen, Xueyi, Arun, Bhavatharini, Nino-Meza, Oscar J., Sarhan, Mona O., Singh, Medha, Jeon, Byeonghoon, Mane, Kishor, Shah, Maunank, Tucker, Elizabeth W., Carroll, Laurence S., Freundlich, Joel S., Peloquin, Charles A., Ivaturi, Vijay D., Jain, Sanjay K.

“…Tuberculosis (TB) remains a leading cause of death, but antibiotic treatments for tuberculous meningitis, the deadliest form of TB, are based on those…”
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Tailoring of Selenium-Plated Novasomes for Fine-Tuning Pharmacokinetic and Tumor Uptake of Quercetin: In Vitro Optimization and In Vivo Radiobiodistribution Assessment in Ehrlich Tumor-Bearing Mice by Aboud, Heba M, Hussein, Amal K, Zayan, Abdallah Z, Makram, Tarek Saad, Sarhan, Mona O, El-Sharawy, Dina M

“…Quercetin (QRC) is a bioflavonoid with anti-inflammatory, antioxidant, and anticancer activities, yet QRC poor bioavailability has hampered its clinical…”
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Development, Potential Anticancer Activity and the Receptor Profile of Different Functionalized 1,3,5-Triazine Derivatives by Sarhan, Mona O, Motaleb, Mohamed A, Ibrahim, Ismail T, Anwar, Manal M, Zaghary, Wafaa A

“…1,3,5-Triazine-based compounds form a privileged class of compounds in the medicinal chemistry field as they are versatile synthetic scaffolds possessing wide…”
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New phenothiazine conjugates as apoptosis inducing agents: Design, synthesis, In-vitro anti-cancer screening and 131I-radiolabeling for in-vivo evaluation by Sarhan, Mona O., Haffez, Hesham, Elsayed, Nosaiba A., El-Haggar, Radwan S., Zaghary, Wafaa A.

“…[Display omitted] •Design and synthesis of seventeen phenothiazine conjugates were performed and showed promising broad spectrum anti-proliferative…”
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Novel substituted 1,8‐naphthyridines: Design, synthesis, radiolabeling, and evaluation of apoptosis and topoisomerase II inhibition by Abuzahra, Manar M., Ahmed, Nesreen S., Sarhan, Mona O., Mahgoub, Shahenda, Abdelhameed, Ahmed, Zaghary, Wafaa A.

“…A series of seventeen 1,8‐naphthyridine derivatives (5a‐5q) conjugated at N1 to various substituted phenyl rings were designed and synthesized as potential…”
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Extraction, purification and radioiodination of Khellin as cancer theranostic agent by Selim, Adli A., Essa, Basma M., Abdelmonem, Islam M., Amin, Mohamed A., Sarhan, Mona O.

“…Khellin was successfully extracted from Ammi visnaga fruits with a recovery percent of 96.15%. Next radio-iodination of Khellin was successfully achieved with…”
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Tau Protein Targeting Via Radioiodinated Azure A For Brain Theranostics: Radiolabeling, Molecular Docking, in vitro And in vivo Biological Evaluation by Abdelaziz, Gamal, Shamsel‐Din, Hesham A., Sarhan, Mona O., Gizawy, Mohamed A.

“…Azure‐A is one of the phenothiazines (PTZs) derivatives which for decades have been used as antipsychotic drugs due to good lipophilic characteristics which…”
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Multi-functionalization of reduced graphene oxide nanosheets for tumor theragnosis: Synthesis, characterization, enzyme assay, in-silico study, radiolabeling and in vivo targeting evaluation by Sakr, Tamer M., Elsabagh, Mohammed F., Fayez, Hend, Sarhan, Mona O., Syam, Yasmin M., Anwar, Manal M., Motaleb, Mohammed A., Zaghary, Wafaa A.

“…Background In this study, a combination of nanotechnology, organic synthesis and radiochemistry were utilized in order to design an efficient nano-system…”
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Radioiodination and biological distribution of a new s‐triazine derivative for tumor uptake evaluation by Motaleb, Mohamed A., Ibrahim, Ismail T., Sarhan, Mona O., Zaghary, Wafaa A.

“…A newly synthesized s‐triazine derivative 1,1′,1″‐(((1,3,5‐triazine‐2,4,6‐triyl) tris (azanediyl)) tris (benzene‐4,1‐diyl))tris (ethan‐1‐one), (1), was…”
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New 2-aminobenzothiazole derivatives: Design, synthesis, anti-inflammatory and ulcerogenicity evaluation by Awaad, Sara S., Sarhan, Mona O., Mahmoud, Walaa R., Nasr, Tamer, George, Riham F., Georgey, Hanan H.

“…•Novel twenty benzothiazole amides were designed as anti-inflammatory agents.•Compounds 3h, 6a were the most potent with comparable activities to…”
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1954. Dynamic PET facilitated Modeling and Novel Antibiotic Regimens for Tuberculous Meningitis due to Multidrug-Resistant Strains by Chen, Xueyi, Nino-Meza, Oscar J, Sarhan, Mona O, Arun, Bhavatharini, Jeon, Byeonghoon, Ordonez, Alvaro A, Carroll, Laurence S, Peloquin, Charles A, Freundlich, Joel, Ivaturi, Vijay, Jain, Sanjay K

“…Abstract Background Tuberculous meningitis is the most serious form of tuberculosis (TB), affecting the young and immunocompromised. TB meningitis due to…”
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