Search Results - "Sarhan, Hatem"

Polyethylene glycol (PEG): The nature, immunogenicity, and role in the hypersensitivity of PEGylated products by Ibrahim, Mohamed, Ramadan, Eslam, Elsadek, Nehal E., Emam, Sherif E., Shimizu, Taro, Ando, Hidenori, Ishima, Yu, Elgarhy, Omar Helmy, Sarhan, Hatem A., Hussein, Amal K., Ishida, Tatsuhiro

“…Polyethylene glycol (PEG) is a versatile polymer that is widely used as an additive in foods and cosmetics, and as a carrier in PEGylated therapeutics. Even…”
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PEGylated liposomes: immunological responses by Mohamed, Marwa, Abu Lila, Amr S., Shimizu, Taro, Alaaeldin, Eman, Hussein, Amal, Sarhan, Hatem A., Szebeni, Janos, Ishida, Tatsuhiro

“…A commonly held view is that nanocarriers conjugated to polyethylene glycol (PEG) are non-immunogenic. However, many studies have reported that unexpected…”
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Optimization and evaluation of propolis liposomes as a promising therapeutic approach for COVID-19 by Refaat, Hesham, Mady, Fatma M., Sarhan, Hatem A., Rateb, Heba S., Alaaeldin, Eman

“…[Display omitted] The present work aimed to develop an optimized liposomal formulation for enhancing the anti-viral activity of propolis against COVID-19…”
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Design And Characterisation Of Novel Sorafenib-Loaded Carbon Nanotubes With Distinct Tumour-Suppressive Activity In Hepatocellular Carcinoma by Elsayed, Mahmoud Ma, Mostafa, Mahmoud E, Alaaeldin, Eman, Sarhan, Hatem Aa, Shaykoon, Montaser ShA, Allam, Shady, Ahmed, Ahmed Rh, Elsadek, Bakheet Em

“…Over the past 30 years, no consistent survival benefits have been recorded for anticancer agents of advanced hepatocellular carcinoma (HCC), except for the…”
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Optimization and Characterization of Thymoquinone-Loaded Liposomes with Enhanced Topical Anti-inflammatory Activity by Mostafa, Mahmoud, Alaaeldin, Eman, Aly, Usama Farghaly, Sarhan, Hatem A.

“…Thymoquinone, the major constituent of Nigella sativa oil has been found to have a promising topical anti-inflammatory activity; however, exaggerated heat and…”
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Design, characterization and in vivo evaluation of modified release baclofen floating coated beads by Ibrahim, Mohamed, Sarhan, Hatem A., Naguib, Youssef W., Abdelkader, Hamdy

“…[Display omitted] •Optimization of gas-forming agent-to-polymer is important for floating characteristics.•Eudragit Rs 100 and Eudragit L100 were superior…”
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Investigation of anti-PEG antibody response to PEG-containing cosmetic products in mice by Ibrahim, Mohamed, Shimizu, Taro, Ando, Hidenori, Ishima, Yu, Elgarhy, Omar Helmy, Sarhan, Hatem A., Hussein, Amal K., Ishida, Tatsuhiro

“…Polyethylene glycol (PEG), a polyether compound, is available in molecular weights from ∼300 g/mol to ∼10,000,000 g/mol. In the molecular weight range of ∼750…”
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Hepatosplenic phagocytic cells indirectly contribute to anti-PEG IgM production in the accelerated blood clearance (ABC) phenomenon against PEGylated liposomes: Appearance of an unexplained mechanism in the ABC phenomenon by El Sayed, Marwa Mohamed, Takata, Haruka, Shimizu, Taro, Kawaguchi, Yoshino, Abu Lila, Amr S., Elsadek, Nehal E., Alaaeldin, Eman, Ishima, Yu, Ando, Hidenori, Kamal, Amal, Sarhan, Hatem A., Ishida, Tatsuhiro

“…The accelerated blood clearance (ABC) phenomenon, caused in large degree via in vivo anti-PEG IgM production, is one of obstacles for development of PEGylated…”
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Using Bio-Layer Interferometry to Evaluate Anti-PEG Antibody-Mediated Complement Activation by Mostafa, Mahmoud, Elsadek, Nehal E., Emam, Sherif E., Ando, Hidenori, Shimizu, Taro, Abdelkader, Hamdy, Ishima, Yu, Aly, Usama Farghaly, Sarhan, Hatem A., Ishida, Tatsuhiro

“…The purpose of this study was to develop a Bio-layer interferometry (BLI) system that could be an alternative approach for the direct evaluation of…”
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Modified Spraying Technique and Response Surface Methodology for the Preparation and Optimization of Propolis Liposomes of Enhanced Anti-Proliferative Activity against Human Melanoma Cell Line A375 by Refaat, Hesham, Naguib, Youssef W, Elsayed, Mahmoud M A, Sarhan, Hatem A A, Alaaeldin, Eman

“…Propolis is a honeybee product that contains a mixture of natural substances with a broad spectrum of biological activities. However, the clinical application…”
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Vitamin B12-Loaded Buccoadhesive Films as a Noninvasive Supplement in Vitamin B12 Deficiency: In Vitro Evaluation and In Vivo Comparative Study With Intramuscular Injection by Mohamad, Soad A, Sarhan, Hatem A, Abdelkader, Hamdy, Mansour, Heba F

“…This study aimed to formulate and evaluate vitamin B12-loaded buccal mucoadhesive hydrogel films. Various film formulations were prepared using chitosan and…”
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Flurbiprofen-loaded niosomes-in-gel system improves the ocular bioavailability of flurbiprofen in the aqueous humor by El-Sayed, Marwa M., Hussein, Amal K., Sarhan, Hatem A., Mansour, Heba F.

“…The present work aimed to prolong the contact time of flurbiprofen (FBP) in the ocular tissue to improve the drug anti-inflammatory activity. Different niosome…”
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Evaluation of combined famotidine with quercetin for the treatment of peptic ulcer: in vivo animal study by Abourehab, Mohammed A S, Khaled, Khaled A, Sarhan, Hatem A A, Ahmed, Osama A A

“…The aim of this work was to prepare a combined drug dosage form of famotidine (FAM) and quercetin (QRT) to augment treatment of gastric ulcer. FAM was prepared…”
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A mouse model for studying the effect of blood anti-PEG IgMs levels on the in vivo fate of PEGylated liposomes by El Sayed, Marwa M., Shimizu, Taro, Abu Lila, Amr S., Elsadek, Nehal E., Emam, Sherif E., Alaaeldin, Eman, Kamal, Amal, Sarhan, Hatem A., Ando, Hidenori, Ishima, Yu, Ishida, Tatsuhiro

“…[Display omitted] The presence of anti-polyethylene glycol (PEG) antibodies in the systemic circulation might have potential implications for the therapeutic…”
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Mitral valve replacement through mini sternotomy after long ECMO course: Case report by Abdalghafoor, Tamer, Sarhan, Hatem, Kindawi, Ali

“…Introduction: Mitral regurgitation (MR) is defined as an abnormal reversal of blood flow from the left ventricle to the left atrium (LA). It is caused by…”
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Tolmetin Sodium Fast Dissolving Tablets for Rheumatoid Arthritis Treatment: Preparation and Optimization Using Box-Behnken Design and Response Surface Methodology by Elsayed, Mahmoud M A, Aboelez, Moustafa O, Elsadek, Bakheet E M, Sarhan, Hatem A, Khaled, Khaled Ali, Belal, Amany, Khames, Ahmed, Hassan, Yasser A, Abdel-Rheem, Amany A, Elkaeed, Eslam B, Raafat, Mohamed, Elsadek, Mahmoud Elkot Mostafa

“…Tolmetin sodium (TLM) is a non-steroidal anti-inflammatory drug (NSAIDs). TLM is used to treat inflammation, skeletal muscle injuries, and discomfort…”
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Applying Different Techniques to Improve the Bioavailability of Candesartan Cilexetil Antihypertensive Drug by Aly, Usama Farghaly, Sarhan, Hatem Abdel-Monsef, Ali, Taha F S, Sharkawy, Hosny Abd El-Bakey

“…The objective of this study was to compare different techniques to enhance the solubility and dissolution rate, and hence the bioavailability of candesartan…”
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Brain Targeting of Citicoline Sodium via Hyaluronic Acid-Decorated Novel Nano-Transbilosomes for Mitigation of Alzheimer's Disease in a Rat Model: Formulation, Optimization, in vitro and in vivo Assessment by AbouElhassan, Kariman M, Sarhan, Hatem A, Hussein, Amal K, Taye, Ashraf, Ahmed, Yasmin M, Safwat, Mohamed A

“…Alzheimer's disease (AD) is one of the furthermost advanced neurodegenerative disorders resulting in cognitive and behavioral impairment. Citicoline sodium…”
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Effect of Chemical Binding of Doxorubicin Hydrochloride to Gold Nanoparticles, Versus Electrostatic Adsorption, on the In Vitro Drug Release and Cytotoxicity to Breast Cancer Cells by Zayed, Gamal M., Kamal, Islam, Abdelhafez, Wael A., M. Alsharif, Fahd, Amin, Mohamed A., Shaykoon, Montaser Sh. A., Sarhan, Hatem A., Abdelsalam, Ahmed M.

“…Purpose The selective delivery of chemotherapeutic agent to the affected area is mainly dependent on the mode of drug loading within the delivery system. This…”
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Co-administration of liposomal l-OHP and PEGylated TS shRNA-lipoplex: A novel approach to enhance anti-tumor efficacy and reduce the immunogenic response to RNAi molecules by Alaaeldin, Eman, Abu Lila, Amr S., Ando, Hidenori, Fukushima, Masakazu, Huang, Cheng-Long, Wada, Hiromi, Sarhan, Hatem A., Khaled, Khaled A., Ishida, Tatsuhiro

“…Many therapeutic strategies have been applied in efforts to conquer the development and/or progression of cancer. The combination of chemotherapy and an…”
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