Search Results - "Sarhan, Alaadin E."

Novel Pyrazolines and Benzothiazepines as Tubulin Polymerization Inhibitors: Synthesis, Biological Evaluation, and Molecular Docking by E. Sarhan, Alaadin, A. Sediek, Ashraf, M. Khalifa, Nagy, E. Hasan, Essam

Get full text

Design, synthesis, biological evaluation, and molecular docking of novel quinazolinone EGFR inhibitors as targeted anticancer agents by Nofal, Zinab M., Amin, Kamelia M., Mohamed, Hanaa S., El-Kerdawy, Ahmed M., Aly, Magdy S., Habib, Basma S., Sarhan, Alaadin E.

“…A novel series of 2-methyl-3-phenylquinazolin-4-one derivatives were synthesized and biologically evaluated for their cytotoxic potential against MCF-7, HepG2,…”
Get full text

Design and synthesis of indole-based elipticine analogues as topoisomerase IIβ inhibitors by El Sayed, Mardia T., Sarhan, Alaadin E., Alturaifi, Huriyyah A., El-Sayed, Selwan M., Hassan, Ghada S., Hamdy, Nehal A., El-Messery, Shahenda M., Ali, Mamdouh M.

“…New ellipticine analogs with indole cores were synthesized. and evaluated for their anticancer activity. A new compound, scaffolds, revealed broad-spectrum…”
Get full text

DNA binding studies of novel diazatruxenones analogs as potential anticancer agents: Synthesis, antitumor investigation, DNA binding, SAR and molecular modeling calculation by El Sayed, Mardia T., Shabaan, Sara N., Sarhan, Alaadin E., El-Messery, Shahenda M., El-Sayed, Selwan M., Hassan, Ghada S.

“…[Display omitted] •A series of polycyclic skeleton of truxene and triazatruxene analogs has been synthesized.•The synthesized candidates have been evaluated…”
Get full text

Synthesis and Characterization of New Dihydronaphthalene Candidates as Potent Cytotoxic Agents against MCF-7 Human Cancer Cells by Haiba, Mogedda E., Amr, Abd El-Galil E., Al-Ashmawy, Aisha A. K., Sarhan, Alaadin E., Ahmed, Nesreen S., Elsayed, Elsayed A.

“…In the present work, a new series of dihydronaphthalene derivatives were synthesized starting with 6-methoxy-1-tetralone 1, and the corresponding hydrazine…”
Get full text

Towards breast cancer targeting: Synthesis of tetrahydroindolocarbazoles, antibreast cancer evaluation, uPA inhibition, molecular genetic and molecular modelling studies by Ahmed, Entesar M., Sarhan, Alaadin E., El-Naggar, Dina H., Khattab, Reham R., El-Naggar, Mohamed, El-Messery, Shahenda M., Hassan, Ghada S., Mounier, Marwa M., Mahmoud, Khaled, Ali, Neama I., Mahrous, Karima F., Ali, Mamdouh M., El Sayed, Mardia T.

“…[Display omitted] •New series of tetrahydroindolocarbazole derivatives has been synthesized.•Compound 11 expressed GI% values of 99.9% against MCF7 breast…”
Get full text

SYNTHESIS AND UTILITY OF NEW POLYCYCLIC COMPOUNDS AS POTENTIAL ANTIMICROBIALS BASED ON CHROMENE MOIETY by N. ABDELAZIZ, MAHMOUD, S. ZARIE, EMAN, SARHAN, ALAADIN E.

“…Objective: The present research aims to synthesize some new polycyclic compounds including chromene moiety and study their antimicrobial activity. Methods:…”
Get full text

Synthesis, Cytotoxicity Evaluation, and Molecular Docking Studies of Novel Pyrrole Derivatives of Khellin and Visnagin via One-Pot Condensation Reaction with Curcumin by Nagwa M. Fawzy, Sarhan, Alaadin E., Elhefny, Eman A., Nasef, Atiat M., Aly, Magdy S.

“…Novel pyrrole derivatives were synthesized by one-pot four components condensation reaction of khellin and/or visnagin carbaldehyde; amine derivatives;…”
Get full text

Novel Pyruvate Kinase (PK) Inhibitors: New Target to Overcome Bacterial Resistance by El Sayed, Mardia T., Sarhan, Alaadin E., Ahmed, Entsar, Khattab, Reham R., Elnaggar, Mohamed, El‐Messery, Shahenda M., Shaldam, Moataz A., Hassan, Ghada S.

“…In the present investigation, some novel nitro Mannich bases derived from Michael type addition of activated nitro olefin, β‐nitrostyrene with various amines…”
Get full text